High risk of metabolic syndrome after delivery in pregnancies complicated by gestational diabetes
Open accessAbstract
Aims To investigate the risk of postpartum metabolic syndrome in women with GDM compared with those without GDM in a Chinese population. Methods Tianjin GDM observational study included 1263 women with a history of GDM and 705 women without GDM. Multivariate logistic regression was used to assess risks of postpartum metabolic syndrome between women with and without GDM. Postpartum metabolic syndrome was diagnosed by two commonly used criteria. Results During a mean 3.53 years of follow up, 256 cases of metabolic syndrome were identified by using the NCEP ATPIII criteria and 244 cases by using the IDF criteria. Multivariable-adjusted odds ratios of metabolic syndrome in women with GDM compared with those without GDM were 3.66 (95% confidence interval [CI] 2.02-6.63) for NCEP ATPIII criteria and 3.90 (95% CI 2.13-7.14) for IDF criteria. Women with GDM had higher multivariable-adjusted odds ratios of central obesity, hypertriglyceridemia, and high blood pressure than women without GDM. The multivariable-adjusted odds ratios of low HDL cholesterol and hyperglycemia were not significant between women with and without GDM, however, the multivariable-adjusted odds ratio of hyperglycemia became significant when we used the modified criteria. Conclusions The present study indicated that women with prior GDM had significantly higher risks for postpartum metabolic syndrome, as well as its individual components.
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GDM is considered an important risk factor for subsequent metabolic disorders, including metabolic syndrome, which in turn increases the risk of cardiovascular diseases (CVDs).
“GDM is considered an important risk factor for subsequent metabolic disorders, including metabolic syndrome, which in turn increases the risk of cardiovascular diseases (CVDs) [10,11].”
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Tranidou, A., Dagklis, T., Tsakiridis, I., Siargkas, A., Apostolopoulou, A., Mamopoulos, A., Goulis, D. G., & Chourdakis, M. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01464-6 · Cited by 43 · see citing works
Tsushima, R., Ito, A., Oishi, M., Ishihara, K., Iino, K., Tanaka, K., & Yokoyama, Y. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15072634
“…women with a history of GDM have an approximately 2.5-fold higher risk of developing metabolic syndrome [9], and GDM is considered an important risk factor for subsequent metabolic disorders, including metabolic syndrome, which in turn increases the risk of cardiovascular diseases (CVDs) [10,11].”
Influential
- Authors
- Shen, Y., Li, W., Leng, J., Zhang, S., Liu, H., Li, W., Wang, L., Tian, H., Chen, J., Qi, L., Yang, X., Yu, Z., Tuomilehto, J., & Hu, G.
- Affiliations
- Pennington Biomedical Research Center (US)
- Tianjin Women's and Children's Health Center (CN)
- University of Pennsylvania (US)
- Tulane University (US)
- Tianjin Medical University (CN)
- Dalhousie University (CA)
- University of Helsinki (FI)
- Corresponding author
- Hu, Gang
- ORCID
- Venue
- Diabetes Research and Clinical Practice
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 150
- Pages
- 219-226
- ISSN
- 0168-8227 (ISSN-L)
- PMC
- PMC6525054
- OpenAlex
- W2924049993
- Cited by
- 49
- References
- 4
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 9 · 2023: 4 · 2022: 9 · 2021: 12 · 2020: 6 · 2019: 3
- FWCI
- 8.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Diabetes Research and Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Työväentutkimus Vuosikirja (submittedVersion, other-oa)
- Funders
- National Institute of General Medical Sciences
- National Institute of Diabetes and Digestive and Kidney Diseases
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- gestational diabetes mellitus, abdominal obesity, hypertriglyceridemia, hypertension, hyperglycemia, low HDL cholesterol, IDF criteria
- MeSH terms
- Adult, Female, Humans, Obesity, Pregnancy, Prognosis, Risk Factors, United States, Incidence, Diabetes, Gestational, Metabolic Syndrome, Postpartum Period
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