Differential gene expression data from the human central nervous system across Alzheimer's disease, Lewy body diseases, and the amyotrophic lateral sclerosis and frontotemporal dementia spectrum
Open accessAbstract
In Noori et al. [1], we hypothesized that there is a shared gene expression signature underlying neurodegenerative proteinopathies including Alzheimer's disease (AD), Lewy body diseases (LBD), and the amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) spectrum. To test this hypothesis, we performed a systematic review and meta-analysis of 60 human central nervous system transcriptomic datasets in the public Gene Expression Omnibus and ArrayExpress repositories, comprising a total of 2,600 AD, LBD, and ALS-FTD patients and age-matched controls which passed our stringent quality control pipeline. Here, we provide the results of differential expression analyses with data quality reports for each of these 60 datasets. This atlas of differential expression across AD, LBD, and ALS-FTD may guide future work to elucidate the pathophysiological drivers of these individual diseases as well as the common substrate of neurodegeneration.
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Previous bulk transcriptomic analyses have highlighted energy metabolism deficits as a feature of AD and other neurodegenerative diseases.
“previous bulk transcriptomic analyses have highlighted energy metabolism deficits as a feature of AD and other neurodegenerative diseases43,44”
From Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease (2024) · cites this paper as [44]
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Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease
Serrano-Pozo, A., Li, H., Li, Z., Muñoz-Castro, C., Jaisa-aad, M., Healey, M. A., Welikovitch, L. A., Jayakumar, R., Bryant, A. G., Noori, A., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01791-4 · Cited by 140 · see citing works
Self-citation
- Authors
- Noori, A., Mezlini, A. M., Hyman, B. T., Serrano-Pozo, A., & Das, S.
- Affiliations
- Harvard University (US)
- Corresponding author
- Das, Sudeshna
- Venue
- Data in Brief
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 35
- Pages
- 106863
- ISSN
- 2352-3409 (ISSN-L)
- PMC
- PMC7903289
- OpenAlex
- W3126630208
- Cited by
- 11
- References
- 1
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 4
- Type
- data paper
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Data in Brief (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- NIA
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, Lewy body disease, amyotrophic lateral sclerosis, frontotemporal dementia, differential gene expression, neurodegenerative proteinopathies
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