Ubiquitin specific peptidase 1 promotes hepatic fibrosis through positive regulation of CXCL1 by deubiquitinating SNAIL

Collagen Structure and Stability

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Mechanisms of hepatic stellate cell activation

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Hepatic stellate cells as key target in liver fibrosis

Higashi, T., Friedman, S. L., & Hoshida, Y. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.05.007 · Cited by 1,485 · see citing works

The Snail genes as inducers of cell movement and survival: implications in development and cancer

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TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis

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Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation

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Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway

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Pathophysiology of liver fibrosis and the methodological barriers to the development of anti-fibrogenic agents

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Intercellular crosstalk of hepatic stellate cells in liver fibrosis: New insights into therapy

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The Chemokine Receptors CXCR1 and CXCR2 Couple to Distinct G Protein-Coupled Receptor Kinases To Mediate and Regulate Leukocyte Functions

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USP1 links platinum resistance to cancer cell dissemination by regulating Snail stability

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Modulation of hepatic stellate cells and reversibility of hepatic fibrosis

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Glutamine inhibits CCl4 induced liver fibrosis in mice and TGF-β1 mediated epithelial–mesenchymal transition in mouse hepatocytes

Shrestha, N., Chand, L., Han, M., Lee, S. O., Kim, C. Y., & Jeong, Y. J. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.04.024 · Cited by 97 · see citing works

Chemical and semisynthetic approaches to study and target deubiquitinases

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Epigenetic reprogramming in liver fibrosis and cancer

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Ubiquitin-specific protease 8 (USP8/UBPy): a prototypic multidomain deubiquitinating enzyme with pleiotropic functions

Dufner, A., & Knobeloch, K. (2019) · Biochemical Society Transactions · doi:10.1042/bst20190527 · Cited by 78 · see citing works

Nrf2 and Snail-1 in the prevention of experimental liver fibrosis by caffeine

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α-smooth muscle actin and ACTA2 gene expressions in vasculopathies

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Ubiquitination and deubiquitination emerge as players in idiopathic pulmonary fibrosis pathogenesis and treatment

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CD147 Promotes CXCL1 Expression and Modulates Liver Fibrogenesis

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Apelin promotes hepatic fibrosis through ERK signaling in LX-2 cells

Wang, Y., Song, J., Bian, H., Bo, J., Lv, S., Pan, W., & Lv, X. (2019) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03581-0 · Cited by 44 · see citing works

β‐Arrestin1 enhances liver fibrosis through autophagy‐mediated Snail signaling

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Small molecule inhibitor of HSP47 prevents pro-fibrotic mechanisms of fibroblasts in vitro

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α‐SMA Overexpression Associated With Increased Liver Fibrosis in Infants With Biliary Atresia

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USP1 Maintains the Survival of Liver Circulating Tumor Cells by Deubiquitinating and Stabilizing TBLR1

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Cylindromatosis—A Protective Molecule against Liver Diseases

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CXCL1 expression is correlated with Snail expression and affects the prognosis of patients with gastric cancer

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New specific HSP47 functions in collagen subfamily chaperoning

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Bone morphogenetic protein-7 regulates Snail signaling in carbon tetrachloride-induced fibrosis in the rat liver

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Mutations in the ‘Fingers’ subdomain of the deubiquitinase USP 1 modulate its function and activity

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Healing gone wrong: convergence of hemostatic pathways and liver fibrosis?

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An Autologous Macrophage‐Based Phenotypic Transformation‐Collagen Degradation System Treating Advanced Liver Fibrosis

Duan, B., Liu, Y., Li, X., Han, M., Yu, H., Hong, H., Zhang, L., Xing, L., & Jiang, H. (2024) · Advanced Science · doi:10.1002/advs.202306899 · Cited by 38 · see citing works

Deubiquitinase USP1 enhances CCAAT/enhancer-binding protein beta (C/EBPβ) stability and accelerates adipogenesis and lipid accumulation

Kim, M. S., Baek, J.-H., Lee, J., Sivaraman, A., Lee, K., & Chun, K. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06317-7 · Cited by 34 · see citing works

Ablation of the deubiquitinase USP15 ameliorates nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Baek, J.-H., Kim, M. S., Jung, H. R., Hwang, M.-S., Lee, C.-H., Han, D. H., Lee, Y., Yi, E. C., Im, S., Hwang, I., et al. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01036-7 · Cited by 23 · see citing works

Crosstalk of ubiquitin system and non-coding RNA in fibrosis

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Integrated analysis and validation of TRIM23/p53 signaling pathway in hepatic stellate cells ferroptosis and liver fibrosis

Chen, J., Zhang, R., Li, F., Lin, S., & Wang, J. (2023) · Digestive and Liver Disease · doi:10.1016/j.dld.2023.07.010 · Cited by 9 · see citing works

Interleukin-9 promotes EMT-mediated PM2.5-induced pulmonary fibrosis by activating the STAT3 pathway

Li, Y., Zhong, Y., Li, C., Han, Z., Cui, Y., He, R., Liu, Y., Cui, Q., He, D., Hu, Z., et al. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03864-6 · Cited by 8 · see citing works

CILP2 promotes hypertrophic scar through Snail acetylation by interaction with ACLY

Wang, J., Du, J., Wang, Y., Song, Y., Wu, J., Wang, T., Yu, Z., & Song, B. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167202 · Cited by 7 · see citing works

Deubiquitinases in metabolic diseases, fibrosis and cancer of the liver

Thakur, A., Kubaichuk, K. I., & Kietzmann, T. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2025.120021 · Cited by 5 · see citing works

Transcriptomic analysis of hepatocytes reveals the association between ubiquitin-specific peptidase 1 and yes-associated protein 1 during liver regeneration

Zhao, Y., Zhang, F., Zhang, X., Li, Z., Li, Q., Ni, T., Wang, R., Liu, L., He, Y., & Zhao, Y. (2023) · Regenerative Therapy · doi:10.1016/j.reth.2023.07.004 · Cited by 3 · see citing works

Deubiquitinases in liver diseases: from mechanisms to targeted therapy.

Zhang, Z.-G., Duan, W., Wang, Y.-X., Hao, P., Chen, L., Hao, Z., He, M., Wu, Y., & Luo, H. (2025) · Science China Life Sciences · doi:10.1007/s11427-025-3100-1 · Cited by 3 · see citing works

A Novel Insight into Chronic Pancreatitis Pathogenesis: the USP1/ITGB5 Axis-Mediated Stellate Cell Activation

Wang, D., Shi, Y., Lu, J., Bao, W. J., Wang, N., Shen, Q., Lin, Z., Qian, L., & Zhu, C. (2026) · Inflammation · doi:10.1007/s10753-025-02434-x · Cited by 2 · see citing works

CXCL1 Promotes Fibrotic Remodeling in Atrial Fibrillation via Activation of TXNDC5 and Endoplasmic Reticulum Stress

Yin, R., Wu, C., Yu, S., Huang, K., Wen, Y., Nie, J., & Ying, R. (2025) · Cardiovascular Therapeutics · doi:10.1155/cdr/7892499

LPA1-Induced EMT of Retinal Pigment Epithelial Cells Promotes Subretinal Fibrosis via USP1-Mediated Deubiquitination and Stabilization of ZEB1

Zhu, M., Cui, L., Guo, Y., Tu, Y., Wang, Y., Zhou, W., Zhang, Y., Xie, L., & Jin, H. (2026) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.67.10.34

USP9X-mediated NRP1 deubiquitination promotes liver fibrosis by activating hepatic stellate cells

Zhao, J., Bai, J., Peng, F., Qiu, C., Li, Y., & Zhong, L. (2023) · Cell Death and Disease · doi:10.1038/s41419-022-05527-9 · Cited by 33 · see citing works

Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease

Wilson, C. L., Murphy, L. B., Leslie, J., Kendrick, S. F. W., French, J., Fox, C. R., Sheerin, N., Fisher, A., Robinson, J. H., TINIAKOS, D. G., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.07.034 · Cited by 54 · see citing works

Deubiquitinase USP18 inhibits hepatic stellate cells activation and alleviates liver fibrosis via regulation of TAK1 activity

Zhang, Y., Gao, J., Liu, Y., Zhong, L., He, S., & Qiu, C. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.114235 · Cited by 9 · see citing works

USP13 promotes hepatic stellate cells activation and aggravates liver fibrosis through deubiquitinating SMAD3

Wang, A., Dong, H., Cui, Y., Zhu, W., Ye, J., Jin, L., Xiong, Y., Zhang, Q., Lin, M., Han, J., et al. (2025) · Hepatology International · doi:10.1007/s12072-025-10880-w · Cited by 2 · see citing works

Deubiquitinase USP2 promotes hepatic stellate cell activation via p300 stabilization

Byun, S., Kim, H., Lee, S.-H., Kwon, J.-H., Kim, H., Yoo, J., Park, S., & Yoon, H. (2026) · FEBS Letters · doi:10.1002/1873-3468.70301