The DOI matches its Crossref record; 169 of the 169 references it cites were found in a registry or an index.
DNA mismatch repair and the DNA damage response
Open accessAbstract
This review discusses the role of DNA mismatch repair (MMR) in the DNA damage response (DDR) that triggers cell cycle arrest and, in some cases, apoptosis. Although the focus is on findings from mammalian cells, much has been learned from studies in other organisms including bacteria and yeast [1,2]. MMR promotes a DDR mediated by a key signaling kinase, ATM and Rad3-related (ATR), in response to various types of DNA damage including some encountered in widely used chemotherapy regimes. An introduction to the DDR mediated by ATR reveals its immense complexity and highlights the many biological and mechanistic questions that remain. Recent findings and future directions are highlighted.
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Cites
The DNA-damage response in human biology and disease
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ATR: an essential regulator of genome integrity
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The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
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DNA Damage Sensing by the ATM and ATR Kinases
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Mechanisms and functions of DNA mismatch repair
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Huang, R.-X., & Zhou, P.-K. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0150-x · Cited by 1,198
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Wang, S.-W., Gao, C., Zheng, Y.-M., Yi, L., Lu, J.-C., Huang, X.-Y., Cai, J.-B., Zhang, P.-F., Cui, Y.-H., & Ke, A.-W. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01518-8 · Cited by 478
Eukaryotic Mismatch Repair in Relation to DNA Replication
Kunkel, T. A., & Erie, D. A. (2015) · Annual Review of Genetics · doi:10.1146/annurev-genet-112414-054722 · Cited by 432
Oxidative Stress: Signaling Pathways, Biological Functions, and Disease
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Metadata
- Authors
- Li, Z., Pearlman, A. H., & Hsieh, P.
- Venue
- DNA Repair
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 38
- Pages
- 94-101
- ISSN
- 1568-7856 (ISSN-L)
- 1568-7864
- OpenAlex
- W73080040
- Cited by
- 307
- References
- 169
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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