USP7: Structure, substrate specificity, and inhibition

Pozhidaeva, Alexandra, Bezsonova, Irina·2019·DNA Repair

DOI 10.1016/j.dnarep.2019.02.005

Cited by (181)

Items 101–181 of 181

Understanding the Interactions of Ubiquitin-Specific Protease 7 with Its Substrates through Molecular Dynamics Simulations: Insights into the Role of Its C-Terminal Domains in Substrate Recognition
José Luís Velázquez‐Libera, Julio Caballero, Jans H. Alzate‐Morales, J. Javier Ruiz‐Pernía, Iñaki Tuñón · 2024 · Journal of Chemical Information and Modeling
Complex Inhibitory Activity of Pentacyclic Triterpenoids against Cutaneous Melanoma In Vitro and In Vivo: A Literature Review and Reconstruction of Their Melanoma-Related Protein Interactome
Arseny D. Moralev, Зенкова Марина Аркадьевна, Andrey V. Markov · 2024 · ACS Pharmacology & Translational Science
Backbone and ILV side-chain NMR resonance assignments of the catalytic domain of human deubiquitinating enzyme USP7
Gabrielle J. Valles, Alexandra Pozhidaeva, Dmitry M. Korzhnev, Irina Bezsonova · 2022 · Biomolecular NMR Assignments
Suppression of USP7 negatively regulates the stability of ETS proto-oncogene 2 protein
Hong‐Beom Park, Yosuk Min, Sohyun Hwang, Kwang‐Hyun Baek · 2023 · Biomedicine & Pharmacotherapy
The C-terminal Tail of Ubiquitin-Specific Protease 7 Facilitates Ubiquitin Release and Ensures Efficient Catalytic Turnover
Emilie J. Korchak, Dane H. Geddes-Buehre, Irina Bezsonova · 2025 · Journal of Molecular Biology
AKT and DUBs: a bidirectional relationship
Valentina Serratore, Maria Lucibello, Donatella Malanga, Giuseppe Viglietto, Carmela De Marco · 2025 · Cellular & Molecular Biology Letters
Deubiquitinases in metabolic diseases, fibrosis and cancer of the liver
Ananya Thakur, Kateryna I. Kubaichuk, Thomas Kietzmann · 2025 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
USP17L promotes the 2-cell-like program through deubiquitination of H2AK119ub1 and ZSCAN4
Panpan Shi, Xukun Lu, Kairang Jin, Linlin Liu, Guoxing Yin, Wenying Wang, Lijuan Wang, Lijuan Wang, Lijun Dong, Wei Xie et al. · 2025 · Nature Communications
USP7 promotes chemotherapy resistance and DNA damage response through stabilizing and deubiquitinating KDM4A in bladder cancer
Hailang Yang, Xiaoqiang Liu, Jianqiang Nie, Shuwei Wu, Li Ma, Yi Jiang, Lizhi Zhou, Wen Deng, Qianxi Dong, Situ Xiong et al. · 2025 · Cell Death and Disease
Functional spectrum of USP7 pathogenic variants in Hao–Fountain syndrome: Insights into the enzyme’s activity, stability, and allosteric modulation
Emilie J. Korchak, Mona Sharafi, Isabella Jaen Maisonet, Andres F. Salazar‐Chaparro, Irina V. Semenova, Hamza Khan, Alison O’Neil, Pilar Caro, Christian P. Schaaf, Sara J. Buhrlage et al. · 2025 · Proceedings of the National Academy of Sciences
Insights into the Structural and Energetic Descriptions of Ubiquitin Specific Protease 7 (USP7) Catalytic Mechanisms by Hybrid QM/MM Simulations.
José Luís Velázquez‐Libera, Julio Caballero, Jans H. Alzate‐Morales, J. Javier Ruiz‐Pernía, Iñaki Tuñón · 2023 · ChemCatChem
USP15-USP7 Axis and UBE2T Differential Expression May Predict Pathogenesis and Poor Prognosis in De Novo Myelodysplastic Neoplasm
Luiz Gustavo Carvalho, Tatiana Takahasi Komoto, Daniel Antunes Moreno, João Vitor Caetano Goes, Roberta Taiane Germano de Oliveira, Mayara Magna de Lima Melo, Mariela Estefany Gislene Vera Roa, Paola Gyuliane Gonçalves, Carlos Victor Montefusco-Pereira, Ronald Feitosa Pinheiro et al. · 2023 · International Journal of Molecular Sciences
From concept to application: Exploring the evolution and potential of DUBTAC technology
Danfeng Wang, Wenjian Min, Binjian Jiang, Haopeng Sun, Chengliang Sun, Peng Yang · 2025 · Acta Pharmaceutica Sinica B
USP7 Stabilizes USF1 to Aggravate ox-LDL-Induced Endothelial Injury Through the MYD88/NF-κB Pathway in Atherosclerosis
Jing Liu, Xiangyang Zhang, Zhaoxia Yu, Tieliang Zhang · 2025 · Applied Biochemistry and Biotechnology
EBNA1 Upregulates P53-Inhibiting Genes in Burkitt's Lymphoma Cell Line
Seyed Mohammad Ali Hashemi, Abdolvahab Moradi, Seyed Younes Hosseini, Hadi Razavi Nikoo, Taravat Bamdad, Mahboobeh Razmkhah, Jamal Sarvari, Alijan Tabarraei · 2023 · Reports of Biochemistry and Molecular Biology
Virtual screening of natural products targeting ubiquitin-specific protease 7
Hong‐Ju Li, Yujie Sun, Hua Yin, Yuzhu Zhang, Junhong Yu, Ning Hou, Peng Wang, Huicong Liang, Aowei Xie, Xiaohong Wang et al. · 2024 · Journal of Biomolecular Structure and Dynamics
The deubiquitinase Usp7 in Drosophila melanogaster is required for synaptonemal complex maintenance
Cathleen M. Lake, Jennifer Margaret Gardner, Salam Briggs, Zulin Yu, Grace McKown, R. Scott Hawley · 2024 · Proceedings of the National Academy of Sciences
Structures of USP7 in active and inactive states bound to DNMT1 revealed by cryo-EM
Nao Nakamura, Sae Yoshimi, Amika Kikuchi, Hiroki Onoda, Satomi Kori, Makoto Nakanishi, Atsuya Nishiyama, Kyohei Arita · 2025 · Structure
Molecular targeting of the deubiquitinase USP14 to circumvent cisplatin resistance in ovarian carcinoma and identification of novel inhibitors
Cristina Corno, Debora Russo, Francesco Pignotti, Francesca De Giorgi, Ilaria Penna, Francesco Saccoliti, Matteo Costantino, Luca Mirra, Pietro Pettinari, Nives Carenini et al. · 2025 · Cancer Drug Resistance
Research progress of DUB enzyme in breast cancer
Wei Tang, Ning Li, Jianjun Lai · 2025 · Clinical and Experimental Medicine
USP7 and SET9 Expression in The Oligospermic Human Semen: A Case-Control Study.
Maryam Farahani, Zahra Yaghobi, Mina Ramezani, Zeynab Piravar · 2022 · PubMed Central
USP7 reduction leads to developmental failure of mouse early embryos
Xue Zhang, Xuefeng Xie, Ang Li, Wei Song, Chao Li, Fei Li, Xiaozhen Li, Xiao-yan Fan, Changyin Zhou, Guang Wang et al. · 2023 · Experimental Cell Research
HAUSP Is a Key Epigenetic Regulator of the Chromatin Effector Proteins
Omeima Abdullah, Mahmoud Alhosin · 2021 · Genes
USP7 sustains hematopoietic stem cell homeostasis partially via PU.1 stabilization
Shan, Huizhuang, Zhang, Youping, Xiao, Xinhua, Wu, Wenxuan, Wang, Yingying, Zhu, Chujiao, Bai, Wenhui, Zhang, Ziwei, Zhai, Yuanhui, Yang, Li et al. · 2026 · International Journal of Biological Sciences
Computational analysis of energetic features and intermolecular interactions in protein-inhibitor USP7 complexes
Marcin Ziemniak, Urszula Anna Budniak, P.M. Dominiak, Krzysztof Woźniak · 2025 · Organic & Biomolecular Chemistry
SQSTM1 /p62 Orchestrates Skin Aging via USP7 Degradation
Liu Chen, Xiaoping Wang, Yuchen Wang, Qingxin Yao, Yunyao Liu, Yongcheng Zhu, He Huang, Hedan Yang, Yin Yang, Yuan He et al. · 2025 · Aging Cell
Discovery of indane and naphthalene derivatives as USP7 inhibitors
Xian Zhang, Shudan Tan, Dalin Wang, Huayun Zhu, Di Chen, Yueting Chen, Guangqing Wu, Zhizhen Zhu, Fengyi Zhang, Xing Li et al. · 2025 · European Journal of Medicinal Chemistry
Quercetin, a Natural Dietary Flavonoid, Emerges a Novel USP7 Inhibitor with Anti-colorectal Cancer Effects
Xue Li, Qiyan Li, Ying Huang, Heyang Zhou, Qianqing Yang, Lingmei Kong · 2025 · Biological and Pharmaceutical Bulletin
Epigenetic Landscapes of Methamphetamine Addiction: Unravelling the Diagnostic Potential of Gene Methylation
Qingxiao Hong, Shanshan Chen, Zhongze Lou, Weisheng Chen, Han Du, Longhui Li, Xiaohu Xie, Wenjin Xu, Wenhua Zhou, Huifen Liu · 2025 · Addiction Biology
S100A9 modulates USP7-mediated stabilization of NCOA4 to promote ferroptosis in sepsis-associated acute lung injury
Yi Wei, Angran Gu, Bailun Wang, Yizheng Yang, Chang Sun, Yi Zhang, Runmeng Liu, Yichen Wang, Changping Gu, Wang Yuelan · 2026 · Redox Biology
Effects of deubiquitylases on the biological behaviors of neural stem cells
Qiqi Zhao, Yixin Li, Xixun Du, Xi Chen, Qian Jiao, Hong Fu Jiang · 2021 · Developmental Neurobiology
Development of a robust HTRF assay with USP7 full length protein expressed in E. coli prokaryotic system for the identification of USP7 inhibitors
Yihui Song, Shu Wang, Min Zhao, Bin Yu · 2023 · Journal of Pharmaceutical and Biomedical Analysis
Deubiquitylase ubiquitin-specific protease 7 plays a crucial role in the lineage differentiation of preimplantation blastocysts
Tong Yu, Xinyi Zhao, Yujie Tang, Yingbing Zhang, Bozhen Ji, Weijia Song, Jianmin Su · 2024 · Biology of Reproduction
USP7 interacts with and destabilizes oncoprotein SET
Jianyuan Chen, Zishan Jiao, Yajing Liu, Meng Zhang, Donglai Wang · 2024 · Biochemical and Biophysical Research Communications
Roles of deubiquitinases in urologic cancers (Review)
Liangpei Wu, Jiahui Wang, Lin Chai, Jun Chen, Xiaofeng Jin · 2024 · Oncology Letters
Protein Modifications During Early Embryo Development
Le Zhang, Yanbing Zhang, Hailong Sun · 2024 · American Journal of Reproductive Immunology
The potential value of microRNA-409-5p-mediated negative regulation of USP7 in the diagnosis and treatment of acute myocardial infarction
Xuemei Fu, Xi Zhang, Lixin Wang, Juan Zhang, W D Li, Shaoxi Qin, Min Zhang, Xiaotian Zheng, Ying Li, Shaobo Yang et al. · 2025 · BMC Cardiovascular Disorders
Beyond Docking: A Multitier Computational Pipeline for USP7 Inhibitor Optimization
Ehsan Sayyah, Muhammet Eren Ulug, Serdar Durdağı · 2025 · ChemMedChem
Cathepsin D inhibition during neuronal differentiation selectively affects individual proteins instead of overall protein turnover
Johannes Schneider, Julia Mitschke, Mahima Bhat, Daniel Vogele, Oliver Schilling, Thomas Reinheckel, Lisa Heß · 2024 · Biochimie
USP7 contributes to cisplatin resistance in non-small cell lung cancer by deubiquitination of BCL2
Zhihao Chen, Wenjun Shang, Gang Huang, Junjie Ying, Ke Shi, Dongxiao Ding, Li Wang, Chong Zhang, Yizheng Tan · 2025 · Molecular & Cellular Toxicology
LOXL2 reduces susceptibility to PARP inhibitors by promoting super-enhancer-regulated DNA damage repair in high-grade serous ovarian cancer
Chunyan Song, Yaying Lin, Chujun Cai, Kangjia Tao, Jiahong Tan, Kairong Xiong, Wen Yang, Jianhua Chi, Zikun Peng, Guangnian Zhao et al. · 2025 · Oncogene
Deubiquitinase USP7 Regulates Neutrophil Extracellular Trap Formation and Inflammation in Lipopolysaccharide‐Treated Mice Through ICAM ‐1 Expression
Huiyan Xu, Qi Wang, Jing‐Xian Fan, Yiming Xu, Jiao Yu · 2025 · The Kaohsiung Journal of Medical Sciences
Cardiac fibroblasts-specific USP7 drives post-infarction cardiac fibrosis by deubiquitinating Krüppel-like factor 7 to promote myofibroblast activation
Jie Yang, Shaopeng Cheng, Hoshun Chong, Qiuyan Zong, Yilin Wang, Tingting Tong, Yi Jiang, Jian Shi, Ronghuang Yu, Xiujuan Cai et al. · 2025 · Journal of Molecular and Cellular Cardiology
Expression and role of deubiquitinating enzymes in thyroid carcinoma
Meiling Huang, Changjiao Yan, Rui Ling, Ting Wang · 2025 · Briefings in Functional Genomics
The Potential Role of Deubiquitinating Enzymes (DUBs) in Male Fertility
Jung Min Kim · 2026 · Biomolecules
Ubiquitin System-Driven Proteostasis in DNA Damage Response
Kusuma Renata, Audrey Regina Valerie, Sisi Qin, Ichiwa Kitty, Kenneth Kevin Joshua, Gayoung Seo, Wootae Kim · 2026 · International Journal of Molecular Sciences
USP7 at PML Nuclear Bodies: A Protein Interaction Network Perspective
Sergey A. Silonov, Е. Ведешкина, Yakov I. Mokin, Dmitriy A. Sukailo, Eugene Y. Smirnov, Vladislav A. Reushev, Туроверов Константин Константинович, Туроверов Константин Константинович, Alexander V. Fonin · 2026 · International Journal of Molecular Sciences
Targeted degradation of USP7 in solid cancer cells reveals distinct effects of deubiquitinase degraders and inhibitors
Nikolas Klink, Sebastian Urban, Johanna A. Seier, Bikash Adhikari, Martin P. Schwalm, Juliane Müller, Madeleine Dorsch, Philine Steinbach, Jiwon Jung, Markus Vogt et al. · 2026 · Nature Communications
Molecular hybridization assisted multi-technique approach for designing USP21 inhibitors to halt catalytic triad-mediated nucleophilic attack and suppress pancreatic ductal adenocarcinoma progression: A molecular dynamics study
Alankar Roy, Sayan Sharma, Ishani Paul, Sujay Ray · 2024 · Computers in Biology and Medicine
Phage Display Screening for Alba Superfamily Proteins from the Human Malaria Parasite, Plasmodium falciparum Reveals a High Level of Association with Protein Modification Pathways and Hints at New Drug Targets
Momoko Tajiri · 2021 · Acta Parasitologica
De-ubiquitination of SAMHD1 by USP7 overcomes oncogenic stress and contributes to chemotherapy insensitivity
Jingwei Liu, Tingting Zhou, Xiang Da Dong, Qiqiang Guo, Lixia Zheng, Xiaoxun Wang, Naijin Zhang, Li DanNi, Ling Ren, Fei Yi et al. · 2021 · Research Square
P53 upregulation by USP7-engaging molecular glues
Boxun Lu, Zhaoyang Li, Ziying Wang, Ping An, Hang Zhang, Chao Zhong, Rui Liu, Z. Ma, Junmei Lü, Chengfang Pan et al. · 2023 · Research Square
Functional characterisation of DHX proteins in the regulation of RNA metabolism and genome stability
Rebecca R. Falk · 2023
Random Forests Regression and Rescoring Strategy for Identifying Inhibitors of Ubiquitin Specific Protease-7
Ahmed Elhadi, Shujing Li, Zheng Yang, Shijun Zhong · 2024 · Journal of Computational Biophysics and Chemistry
The Use of Stem Cell Therapy in the Treatment of Primary Central Nervous System Lymphoma
Vincent S. Gallicchio · 2024
Forward genetic approach identifies a phylogenetically conserved serine residue critical for the catalytic activity of UBIQUITIN-SPECIFIC PROTEASE 12 in Arabidopsis
Anita Hajdu, Dóra Vivien Nyári, Éva Ádám, Yeon Jeong Kim, David E. Somers, Dániel Silhavy, Ferenc Nagy, László Kozma‐Bognár · 2024 · Scientific Reports
Effect of deubiquitinases in head and neck squamous cell carcinoma (Review)
Jiahui Wang, Liangpei Wu, Zhifeng Tian, Jun Chen · 2025 · Oncology Letters
Structural Plasticity Guides Functional Versatility of USP7 in Human Diseases: Mechanistic Insights and Therapeutic Targeting
Xuanyu Xu, 张乃霞, Li Shi · 2025 · Health and Metabolism
USP7 mutations are associated with adverse outcomes in pediatric T cell acute lymphoblastic leukemia and lymphoma
Jun Li, Yuan Yuan, Feng-Feng Niu, Ying Wang, Wei Lin, Ruidong Zhang, Ling Jin, Yanlong Duan, Chao Gao · 2025 · Annals of Hematology
The Small Molecule Compound Eupalinolide B Alleviates Neuropathic Pain by Regulating the USP7/Keap1/Nrf2 Pathway
Xuesong Yang, Fan Zhi Jiang, Juan Li, Yanqiong Wu, Hongbing Xiang · 2025 · Journal of Neuroimmune Pharmacology
MLL1-pioneered H3K4me3 modification on KLF7 promoter accelerates the invasion of fibroblast-like synoviocytes in rheumatoid arthritis
Yurong Cen, Chunhua Yan, Chunmei Qian, Qin Wang · 2026 · In Vitro Cellular & Developmental Biology - Animal
USP7 deubiquitinates Aurora B and promotes hepatocellular carcinoma progression
Zifan Xu, Jinfeng Gan, Shibo Wang, Yuru Zhou, Yuxuan Liu, Lihua Zhou, Guangying Qi, Zhaoquan Huang · 2026 · Acta Biochimica et Biophysica Sinica
USP7 Regulates TRPV1 Deubiquitination to Mediate Chondrocyte Ferroptosis and Alleviate Osteoarthritis
Jun Li, Ding Chen, Wei‐Ye Zhong · 2026 · The Kaohsiung Journal of Medical Sciences
Emerging Therapeutic Targets and Signaling Networks in Ischemia–Reperfusion Injury
Shreeya Bhujbal, Lokesh Kumar Bhatt · 2026 · Advanced Biology
Fonctions et régulations de la kinase CHK1 dans l'hématopoïèse normale et leucémique
Maëlle Cartel · 2019 · theses.fr (ABES)
Control, use and misuse of cellular signalling networks
Pauline Juyoux · 2021 · theses.fr (ABES)
Decoding Deubiquitinases: Roles, Mechanisms, and Therapeutic Implications
Ashish Kabra · 2026 · Biophysica
Deubiquitination of ETV4 by USP7 Promotes NSCLC Tumorigenesis via MAPK7 Activation
Xue Meng, Jiaxi Zhang, Ning Zhang, Yuqi Hou, Yimeng Li, Kang Jia, Ruxin Li, Yinghui Shi, Juan Wang, Lixin Cheng et al. · 2026 · Human Mutation
Emerging roles of USP7 in tumor immune evasion, metabolic reprogramming, and therapeutic resistance
Xiaolin Liu, Bochi Zhu, Li−li Lian, Yun−feng Li · 2026 · Frontiers in Immunology
Intramolecular Interactions between Folded and Disordered Regions Shape Ubiquilin Structure and Function
Jessica K. Niblo, Nirbhik Acharya, M. Watkins, Carlos A. Castañeda, S. Sukenik · 2026 · bioRxiv
Proteome-wide Ubiquitinome Profiling Reveals Substrate-specific Dynamics Within the USP7 Network
Joyce Wolf van der Meer, Jan A. van der Knaap, Ayestha Sijm, Karel Bezstarosti, Dick H. W. Dekkers, Wouter A. S. Doff, Jeroen Demmers, C. Peter Verrijzer · 2026 · Molecular & Cellular Proteomics
Macrophage USP7 aggravates acute myocardial infarction by inhibiting STING degradation through the ESCRT pathway
Wenqian Qi, Ruiqing Ren, Liwen Yu, Lei Cao, Jie Zhang, Xiaohong Wang, Qian Li, Wei Yang, Cheng Zhang, Meng Zhang · 2026 · Cell Death and Differentiation
Deubiquitinase USP7 stabilizes the histone demethylase KDM5B and promotes the progression of renal fibrosis through the TSC1/mTOR axis
Shiqi Lv, Ziyan Shen, Yulu Gu, Yulin Wang, Jiayi Wang, Han Zhang, Hong Liu, Jing Chen, Cheng Zhu, Xinhui Huang et al. · 2026 · Molecular Biomedicine
Targeting USP7 in sarcomas: opportunities and challenges
Sara Franzese, Giuliana Cassinelli · 2026 · Biochemical Pharmacology
The Hao-Fountain syndrome gene USP7 restricts neurotropic orthoflavivirus entry through cell-intrinsic control of endosomal dynamics
Boris Bonaventure, Kyna Reyes, Marie France Martin, Heng Pan, R. Blake Richardson, Eva Bednarski, Alison W. Ashbrook, Allison Sowa, William G.M. Janssen, Oded Danziger et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
GSK3 maintains NSP12 stability to promote bat-origin swine acute diarrhea syndrome coronavirus infection
Maowen Sun, Cong Yuan, Yueyue Duan, Lei Shi, Yu Zhang, Luyao Li, Wenquan Mao, Haixue Zheng, Qi Wang · 2026 · Journal of Virology
BindingDB Entry 50023269: Ubiquitin-Specific Protease 7 (USP7) as a Promising Therapeutic Target for Drug Discovery: From Mechanisms to Therapies.
BindingDB · 2026 · UC San Diego
BindingDB Entry 50018466: Recent advances in the development of ubiquitin-specific-processing protease 7 (USP7) inhibitors.
BindingDB · 2024 · UC San Diego
BindingDB Entry 50013565: Design, synthesis, biological evaluation and structure-activity relationship study of quinazolin-4(3H)-one derivatives as novel USP7 inhibitors.
BindingDB · 2022 · UC San Diego
BindingDB Entry 50022200: Discovery of pyrrolo[2,3-d]pyrimidin-4-one derivative YCH3124 as a potent USP7 inhibitor for cancer therapy.
BindingDB · 2025 · UC San Diego
Host Ubiquitin-Specific Proteases Regulate All Stages of Herpesvirus Infection
Mohamed Maarouf, Christopher S. Peterson, Kareem N. Mohni · 2026 · International Journal of Molecular Sciences