USP7: Structure, substrate specificity, and inhibition

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

Li, M., Chen, D., Shiloh, A., Luo, J., Nikolaev, A. Y., Qin, J., & Gu, W. J. (2002) · Nature · doi:10.1038/nature737 · Cited by 1,027 · see citing works

A dynamic role of HAUSP in the p53-Mdm2 pathway

Li, M., Brooks, C. L., Kon, N., & Gu, W. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00157-1 · Cited by 679 · see citing works

Crystal Structure of a UBP-Family Deubiquitinating Enzyme in Isolation and in Complex with Ubiquitin Aldehyde

Hu, M., Li, P., Li, M., Li, W., Yao, T., Wu, J.-W., Gu, W. J., Cohen, R. E., & Shi, Y. (2002) · Cell · doi:10.1016/s0092-8674(02)01199-6 · Cited by 648 · see citing works

Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

Waters, L. S., Minesinger, B. K., Wiltrout, M. E., D'Souza, S., Woodruff, R. V., & Walker, G. C. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00034-08 · Cited by 591 · see citing works

The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

Song, M. S., Salmena, L., Carracedo, A., Egia, A., Lo-Coco, F., Teruya-Feldstein, J., & Pandolfi, P. P. (2008) · Nature · doi:10.1038/nature07290 · Cited by 548 · see citing works

A novel ubiquitin‐specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein

Everett, R. D., Meredith, M., Orr, A., Cross, A., Kathoria, M., & Parkinson, J. (1997) · The EMBO Journal · doi:10.1093/emboj/16.7.1519 · Cited by 491 · see citing works

FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP

van der Horst, A., de Vries-Smits, A. M. M., Brenkman, A. B., van Triest, M. H., van den Broek, N. J. F., Colland, F., Maurice, M. M., & Burgering, B. M. T. (2006) · Nature Cell Biology · doi:10.1038/ncb1469 · Cited by 479 · see citing works

Molecular basis of USP7 inhibition by selective small-molecule inhibitors.

Turnbull, A. P., Ioannidis, S., Krajewski, W. W., Pinto-Fernandez, A., Heride, C., Martin, A. C. L., Tonkin, L. M., Townsend, E. C., Buker, S. M., Lancia, D. R., et al. (2017) · Nature · doi:10.1038/nature24451 · Cited by 463 · see citing works

Structure and mechanisms of the proteasome‐associated deubiquitinating enzyme USP14

Hu, M., Li, P., Song, L., Jeffrey, P. D., Chenova, T. A., Wilkinson, K. D., Cohen, R. E., & Shi, Y. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600832 · Cited by 430 · see citing works

Deubiquitylases From Genes to Organism

Clague, M. J., Barsukov, I., Coulson, J. M., Liu, H., Rigden, D. J., & Urbé, S. (2013) · Physiological Reviews · doi:10.1152/physrev.00002.2013 · Cited by 422 · see citing works

Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes

Altun, M., Kramer, H., Willems, L. I., McDermott, J. L., Leach, C. A., Goldenberg, S. J., Kumar, S., Konietzny, R., Fischer, R., Kogan, E., et al. (2011) · Chemistry & Biology · doi:10.1016/j.chembiol.2011.08.018 · Cited by 401 · see citing works

Structure of the p53 Binding Domain of HAUSP/USP7 Bound to Epstein-Barr Nuclear Antigen 1

Saridakis, V., Sheng, Y., Sarkari, F., Holowaty, M. N., Shire, K., Nguyen, T., Zhang, R. G., Liao, J. C. C., Lee, W., Edwards, A. M., et al. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.02.029 · Cited by 362 · see citing works

DNMT1 Stability Is Regulated by Proteins Coordinating Deubiquitination and Acetylation-Driven Ubiquitination

Du, Z., Song, J. K., Wang, Y., Zhao, Y., Guda, K., Yang, S., Kao, H., Xu, Y., Willis, J. E., Markowitz, S. D., et al. (2010) · Science Signaling · doi:10.1126/scisignal.2001462 · Cited by 337 · see citing works

USP7 small-molecule inhibitors interfere with ubiquitin binding.

Kategaya, L., Di Lello, P., Rougé, L., Pastor, R., Clark, K. R., Drummond, J., Kleinheinz, T., Lin, E., Upton, J.-P., Prakash, S., et al. (2017) · Nature · doi:10.1038/nature24006 · Cited by 333 · see citing works

Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells

Colland, F., Formstecher, É., Jacq, X., Reverdy, C., Planquette, C., Conrath, S., Trouplin, V., Bianchi, J., Aushev, V. N., Camonis, J., et al. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0097 · Cited by 322 · see citing works

Molecular recognition of p53 and MDM2 by USP7/HAUSP.

Sheng, Y., Saridakis, V., Sarkari, F., Duan, S., Wu, T., Arrowsmith, C. H., & Frappier, L. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1067 · Cited by 315 · see citing works

UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair

Schwertman, P., Lagarou, A., Dekkers, D. H. W., Raams, A., van der Hoek, A. C., Laffeber, C., Hoeijmakers, J. H. J., Demmers, J. A. A., Fousteri, M., Vermeulen, W., et al. (2012) · Nature Genetics · doi:10.1038/ng.2230 · Cited by 279 · see citing works

The Structure of the CYLD USP Domain Explains Its Specificity for Lys63-Linked Polyubiquitin and Reveals a B Box Module

Komander, D., Lord, C. J., Scheel, H., Swift, S., Hofmann, K., Ashworth, A., & Barford, D. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.12.018 · Cited by 276 · see citing works

Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme.

Reverdy, C., Conrath, S., Lopez, R., Planquette, C., Atmanene, C., Collura, V., Harpon, J., Battaglia, V., Vivat, V., Sippl, W., et al. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.02.007 · Cited by 270 · see citing works

[33] Catalytic mechanism in papain family of cysteine peptidases

Storer, A. C., & Ménard, R. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(94)44035-2 · Cited by 265 · see citing works

GMP Synthetase Stimulates Histone H2B Deubiquitylation by the Epigenetic Silencer USP7

van der Knaap, J. A., Kumar, B. R. P., Moshkin, Y. M., Langenberg, K. P. S., Krijgsveld, J., Heck, A. J. R., Karch, F., & Verrijzer, C. P. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.02.013 · Cited by 258 · see citing works

Mechanism of USP7/HAUSP Activation by Its C-Terminal Ubiquitin-like Domain and Allosteric Regulation by GMP-Synthetase

Faesen, A. C., Dirac, A. M. G., Shanmugham, A., Ovaa, H., Anastassis Perrakis, A., & Sixma, T. K. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.034 · Cited by 251 · see citing works

Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53–MDM2 Pathway

Hu, M., Gu, L., Li, M., Jeffrey, P. D., Gu, W., & Shi, Y. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040027 · Cited by 251 · see citing works

The Multifaceted Roles of USP7: New Therapeutic Opportunities

Nicholson, B., & Kumar, S. (2011) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-011-9185-5 · Cited by 243 · see citing works

Critical role for Daxx in regulating Mdm2

Tang, J., Qu, L., Zhang, J., Wang, W., Michaelson, J. S., Degenhardt, Y., El‐Deiry, W. S., & Yang, X. (2006) · Nature Cell Biology · doi:10.1038/ncb1442 · Cited by 239 · see citing works

Protein Profiling with Epstein-Barr Nuclear Antigen-1 Reveals an Interaction with the Herpesvirus-associated Ubiquitin-specific Protease HAUSP/USP7

Holowaty, M. N., Zeghouf, M., Wu, H., Tellam, J., Athanasopoulos, V., Greenblatt, J., & Frappier, L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303977200 · Cited by 228 · see citing works

Discovery and characterization of highly potent and selective allosteric USP7 inhibitors

Gavory, G., O'Dowd, C. R., Helm, M. D., Flasz, J., Arkoudis, E., Dossang, A., Hughes, C., Cassidy, E., McClelland, K., Odrzywol, E., et al. (2018) · Nature Chemical Biology · doi:10.1038/nchembio.2528 · Cited by 224 · see citing works

The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain Types

Faesen, A. C., Luna‐Vargas, M. P. A., Geurink, P. P., Clerici, M., Merkx, R., van Dijk, W. J., Hameed, D. S., Oualid, F. E., Ovaa, H., & Sixma, T. K. (2011) · Chemistry & Biology · doi:10.1016/j.chembiol.2011.10.017 · Cited by 211 · see citing works

USP7 acts as a molecular rheostat to promote WASH-dependent endosomal protein recycling and is mutated in a human neurodevelopmental disorder.

Hao, Y.-H., Fountain, M. D., Fon Tacer, K., Xia, F., Bi, W., Kang, S.-H. L., Patel, A., Rosenfeld, J. A., Le Caignec, C., Isidor, B., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.07.033 · Cited by 206 · see citing works

Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis.

Wang, Q., Ma, S., Song, N., Li, X., Liu, L., Yang, S., Ding, X., Shan, L., Zhou, X., Su, D., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85747 · Cited by 206 · see citing works

Regulation of alphaherpesvirus infections by the ICP0 family of proteins

Boutell, C., & Everett, R. D. (2012) · Journal of General Virology · doi:10.1099/vir.0.048900-0 · Cited by 202 · see citing works

HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma

Tavana, O., Li, D., Dai, C., López, G., Banerjee, D., Kon, N., Chen, C., Califano, A., Yamashiro, D. J., Sun, H., et al. (2016) · Nature Medicine · doi:10.1038/nm.4180 · Cited by 202 · see citing works

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1

Felle, M., Joppien, S., Németh, A., Diermeier, S. D., Thalhammer, V., Dobner, T., Kremmer, E., Kappler, R., & Längst, G. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr528 · Cited by 198 · see citing works

The ubiquitin-proteasome system and autophagy: Coordinated and independent activities

Cohen‐Kaplan, V., Livneh, I., Avni, N., Cohen-Rosenzweig, C., & Ciechanover, A. J. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.07.019 · Cited by 196 · see citing works

Structure-guided development of a potent and selective non-covalent active-site inhibitor of USP7.

Lamberto, I., Liu, X., Seo, H.-S., Schauer, N. J., Iacob, R. E., Hu, W., Das, D., Mikhailova, T., Weisberg, E. L., Engen, J. R., et al. (2017) · Cell Chemical Biology · doi:10.1016/j.chembiol.2017.09.003 · Cited by 192 · see citing works

Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47.

Weinstock, J., Wu, J., Cao, P., Kingsbury, W. D., McDermott, J. L., Kodrasov, M. P., McKelvey, D. M., Suresh Kumar, K. G., Goldenberg, S. J., Mattern, M. R., et al. (2012) · ACS Medicinal Chemistry Letters · doi:10.1021/ml200276j · Cited by 187 · see citing works

Protein Interaction Domains of the Ubiquitin-specific Protease, USP7/HAUSP

Holowaty, M. N., Sheng, Y., Nguyen, T., Arrowsmith, C. H., & Frappier, L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307200200 · Cited by 182 · see citing works

Inactivation of HAUSP in vivo modulates p53 function.

Kon, N., Kobayashi, Y., Li, M., Brooks, C. L., Ludwig, T., & Gu, W. (2010) · Oncogene · doi:10.1038/onc.2009.427 · Cited by 176 · see citing works

Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1

Qin, W., Leonhardt, H., & Spada, F. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22998 · Cited by 163 · see citing works

Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation.

Cheng, J., Yang, H., Fang, J., Ma, L., Gong, R., Wang, P., Li, Z., & Xu, Y. (2015) · Nature Communications · doi:10.1038/ncomms8023 · Cited by 158 · see citing works

Ubiquitin‐specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor

Maertens, G. N., Messaoudi, S. E., Elderkin, S., Hiom, K. J., & Peters, G. G. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.129 · Cited by 155 · see citing works

Amino-terminal Dimerization, NRDP1-Rhodanese Interaction, and Inhibited Catalytic Domain Conformation of the Ubiquitin-specific Protease 8 (USP8)

Avvakumov, G. V., Walker, J. R., Xue, S., Finerty, P. J., MacKenzie, F., Newman, E. M., & Dhe‐Paganon, S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606704200 · Cited by 154 · see citing works

Small‐Molecule Control of Intracellular Protein Levels through Modulation of the Ubiquitin Proteasome System

Buckley, D. L., & Crews, C. M. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201307761 · Cited by 153 · see citing works

Deubiquitination of NF-κB by Ubiquitin-Specific Protease-7 promotes transcription

Colleran, A., Collins, P. E., O’Carroll, C., Ahmed, A., Mao, X., McManus, B., Kiely, P. A., Burstein, E., & Carmody, R. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208446110 · Cited by 150 · see citing works

USP7 is a SUMO deubiquitinase essential for DNA replication.

Lecona, E., Rodriguez-Acebes, S., Specks, J., Lopez-Contreras, A. J., Ruppen, I., Murga, M., Muñoz, J., Mendez, J., & Fernandez-Capetillo, O. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3185 · Cited by 148 · see citing works

ATM-Dependent Downregulation of USP7/HAUSP by PPM1G Activates p53 Response to DNA Damage

Khoronenkova, S. V., Dianova, I. I., Ternette, N., Kessler, B. M., Parsons, J. L., & Dianov, G. L. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.01.021 · Cited by 146 · see citing works

HSV ICP0 recruits USP7 to modulate TLR-mediated innate response

Daubeuf, S., Singh, D., Tan, Y., Liu, H., Federoff, H. J., Bowers, W. J., & Tolba, K. A. (2008) · Blood · doi:10.1182/blood-2008-07-168203 · Cited by 146 · see citing works

The p53–Mdm2–HAUSP complex is involved in p53 stabilization by HAUSP

Brooks, C. L., Li, M., Hu, M., Shi, Y., & Gu, W. (2007) · Oncogene · doi:10.1038/sj.onc.1210531 · Cited by 144 · see citing works

A RING Finger Ubiquitin Ligase Is Protected from Autocatalyzed Ubiquitination and Degradation by Binding to Ubiquitin-specific Protease USP7

Canning, M., Boutell, C., Parkinson, J., & Everett, R. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402885200 · Cited by 142 · see citing works

Ubiquitination-Deubiquitination by the TRIM27-USP7 Complex Regulates Tumor Necrosis Factor Alpha-Induced Apoptosis

Zaman, M. M.-U., Nomura, T., Takagi, T., Okamura, T., Jin, W., Shinagawa, T., Tanaka, Y., & Ishii, S. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00465-13 · Cited by 125 · see citing works

USP7 counteracts SCFβTrCP- but not APCCdh1-mediated proteolysis of Claspin

Faustrup, H., Bekker-Jensen, S., Bartek, J., Lukas, J., & Mailand, N. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200807137 · Cited by 113 · see citing works

Molecular understanding of USP7 substrate recognition and c-terminal activation.

Rougé, L., Bainbridge, T. W., Kwok, M., Tong, R., Di Lello, P., Wertz, I. E., Maurer, T., Ernst, J. A., & Murray, J. (2016) · Structure · doi:10.1016/j.str.2016.05.020 · Cited by 108 · see citing works

USP7-specific inhibitors target and modify the enzyme’s active site via distinct chemical mechanisms.

Pozhidaeva, A., Valles, G., Wang, F., Wu, J., Sterner, D. E., Nguyen, P., Weinstock, J., Kumar, K. G. S., Kanyo, J., Wright, D., et al. (2017) · Cell Chemical Biology · doi:10.1016/j.chembiol.2017.09.004 · Cited by 107 · see citing works

An allosteric interaction links USP7 to deubiquitination and chromatin targeting of UHRF1.

Zhang, Z.-M., Rothbart, S. B., Allison, D. F., Cai, Q., Harrison, J. S., Li, L., Wang, Y., Strahl, B. D., Wang, G. G., & Song, J. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.046 · Cited by 99 · see citing works

Biochemical characterization of USP7 reveals post-translational modification sites and structural requirements for substrate processing and subcellular localization.

Fernández‐Montalván, A., Bouwmeester, T., Joberty, G., Mader, R., Mahnke, M., Pierrat, B., Schlaeppi, J., Worpenberg, S., & Gerhartz, B. (2007) · The FEBS Journal · doi:10.1111/j.1742-4658.2007.05952.x · Cited by 96 · see citing works

Regulation of USP7: A High Incidence of E3 Complexes

Kim, R. Q., & Sixma, T. K. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.05.028 · Cited by 96 · see citing works

The Ubiquitin Ligase RNF220 Enhances Canonical Wnt Signaling through USP7-Mediated Deubiquitination of β-Catenin

Ma, P., Yang, X., Kong, Q., Li, C., Yang, S., Li, Y., & Mao, B. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00731-14 · Cited by 93 · see citing works

USP7 controls Chk1 protein stability by direct deubiquitination.

Alonso-de Vega, I., Martín, Y., & Smits, V. A. (2014) · Cell Cycle · doi:10.4161/15384101.2014.973324 · Cited by 92 · see citing works

Deubiquitinating enzymes in cellular signaling and disease regulation

Hanpude, P., Bhattacharya, S., Dey, A. K., & Maiti, T. K. (2015) · IUBMB Life · doi:10.1002/iub.1402 · Cited by 91 · see citing works

Discovery of small-molecule inhibitors of ubiquitin specific protease 7 (USP7) using integrated NMR and in silico techniques

Di Lello, P., Pastor, R., Murray, J. M., Blake, R. A., Cohen, F., Crawford, T. D., Drobnick, J., Drummond, J., Kategaya, L., Kleinheinz, T., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01293 · Cited by 90 · see citing works

The DUSP–Ubl domain of USP4 enhances its catalytic efficiency by promoting ubiquitin exchange

Clerici, M., Luna‐Vargas, M. P. A., Faesen, A. C., & Sixma, T. K. (2014) · Nature Communications · doi:10.1038/ncomms6399 · Cited by 88 · see citing works

USP7 deubiquitinase promotes ubiquitin-dependent DNA damage signaling by stabilizing RNF168.

Zhu, Q., Sharma, N., He, J., Wani, G., & Wani, A. A. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1007785 · Cited by 87 · see citing works

Ubiquitin-specific Protease 7 Regulates Nucleotide Excision Repair through Deubiquitinating XPC Protein and Preventing XPC Protein from Undergoing Ultraviolet Light-induced and VCP/p97 Protein-regulated Proteolysis

He, J., Zhu, Q., Wani, G., Sharma, N., Han, C., Qian, J., Pentz, K., Wang, Q., & Wani, A. A. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.589812 · Cited by 87 · see citing works

USP7 overexpression predicts a poor prognosis in lung squamous cell carcinoma and large cell carcinoma

Zhao, G., Lin, Z., Lu, C., Gu, J., Yuan, Y., Xu, F., Liu, R., Ge, D., & Ding, J. (2014) · Tumor Biology · doi:10.1007/s13277-014-2773-4 · Cited by 84 · see citing works

Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathway.

Dar, A., Shibata, E., & Dutta, A. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00358-13 · Cited by 83 · see citing works

Stabilization of LSD1 by deubiquitinating enzyme USP7 promotes glioblastoma cell tumorigenesis and metastasis through suppression of the p53 signaling pathway

Yi, L., Cui, Y., Xu, Q., & Jiang, Y. (2016) · Oncology Reports · doi:10.3892/or.2016.5099 · Cited by 83 · see citing works

Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein

Lee, H.-R., Choi, W., Lee, S., Hwang, J., Hwang, E., Guchhait, K., Haas, J., Tóth, Z., Jeon, Y. H., Oh, T.-K., et al. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2142 · Cited by 81 · see citing works

Pathogenic variants in USP7 cause a neurodevelopmental disorder with speech delays, altered behavior, and neurologic anomalies.

Fountain, M. D., Oleson, D. S., Rech, M. E., Segebrecht, L., Hunter, J. V., McCarthy, J. M., Lupo, P. J., Holtgrewe, M., Moran, R., Rosenfeld, J. A., et al. (2019) · Genetics in Medicine · doi:10.1038/s41436-019-0433-1 · Cited by 80 · see citing works

Roles of HAUSP-mediated p53 regulation in central nervous system development

Kon, N., Zhong, J., Kobayashi, Y., Li, M., Szabolcs, M., Ludwig, T., Canoll, P. D., & Gu, W. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2011.12 · Cited by 79 · see citing works

Therapeutic inhibition of USP7-PTEN network in chronic lymphocytic leukemia: a strategy to overcome TP53 mutated/deleted clones

Carrà, G., Panuzzo, C., Torti, D., Parvis, G. E., Crivellaro, S., Familiari, U., Volante, M., Morena, D., Lingua, M. F., Brancaccio, M., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16348 · Cited by 78 · see citing works

USP7 is essential for maintaining Rad18 stability and DNA damage tolerance.

Zlatanou, A., Sabbioneda, S., Miller, E. S., Greenwalt, A., Aggathanggelou, A., Maurice, M. M., Lehmann, A. R., Stankovic, T., Reverdy, C., Colland, F., et al. (2016) · Oncogene · doi:10.1038/onc.2015.149 · Cited by 77 · see citing works

BCR-ABL disrupts PTEN nuclear-cytoplasmic shuttling through phosphorylation-dependent activation of HAUSP

Morotti, A., Panuzzo, C., Crivellaro, S., Pergolizzi, B., Familiari, U., Berger, A. H., Saglio, G. N., & Pandolfi, P. P. (2013) · Leukemia · doi:10.1038/leu.2013.370 · Cited by 74 · see citing works

Proteomic Profiling of the Human Cytomegalovirus UL35 Gene Products Reveals a Role for UL35 in the DNA Repair Response

Salsman, J., Jagannathan, M., Paladino, P., Chan, P.-K., Dellaire, G., Raught, B., & Frappier, L. (2011) · Journal of Virology · doi:10.1128/jvi.05442-11 · Cited by 73 · see citing works

Crystal Structure of USP7 Ubiquitin-like Domains with an ICP0 Peptide Reveals a Novel Mechanism Used by Viral and Cellular Proteins to Target USP7

Pfoh, R., Lacdao, I. K., Georges, A. A., Capar, A., Zheng, H. X., Frappier, L., & Saridakis, V. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004950 · Cited by 72 · see citing works

Regulation of the Polycomb protein RING1B ubiquitination by USP7

de Bie, P., Zaaroor-Regev, D., & Ciechanover, A. J. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.08.082 · Cited by 71 · see citing works

A role for USP7 in DNA replication.

Jagannathan, M., Nguyen, T., Gallo, D., Luthra, N., Brown, G. W., Saridakis, V., & Frappier, L. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00639-13 · Cited by 71 · see citing works

Identification and structure-guided development of pyrimidinone based USP7 inhibitors

O’Dowd, C. R., Helm, M. D., Rountree, J. S. S., Flasz, J. T., Arkoudis, E., Miel, H., Hewitt, P. R., Jordan, L., Barker, O., Hughes, C., et al. (2018) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.7b00512 · Cited by 71 · see citing works

Usp7-dependent histone H3 deubiquitylation regulates maintenance of DNA methylation

Yamaguchi, L., Nishiyama, A., Misaki, T., Johmura, Y., Ueda, J., Arita, K., Nagao, K., Obuse, C., & Nakanishi, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-00136-5 · Cited by 69 · see citing works

Expression of USP7 and MARCH7 Is Correlated with Poor Prognosis in Epithelial Ovarian Cancer

Zhang, L., Wang, H., Tian, L., & Li, H. (2016) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.239.165 · Cited by 67 · see citing works

C-terminal region of USP7/HAUSP is critical for deubiquitination activity and contains a second mdm2/p53 binding site

Ma, J., Martin, J. D., Xue, Y., Lor, L. A., Kennedy-Wilson, K. M., Sinnamon, R. H., Ho, T. F., Zhang, G., Schwartz, B. K., Tummino, P. J., et al. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.08.020 · Cited by 67 · see citing works

The role of UBL domains in ubiquitin-specific proteases

Faesen, A. C., Luna‐Vargas, M. P. A., & Sixma, T. K. (2012) · Biochemical Society Transactions · doi:10.1042/bst20120004 · Cited by 66 · see citing works

USP7 and Daxx regulate mitosis progression and taxane sensitivity by affecting stability of Aurora-A kinase.

Giovinazzi, S., Morozov, V. M., Summers, M. K., Reinhold, W. C., & Ishov, A. M. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2012.169 · Cited by 65 · see citing works

The Ubiquitin-Specific Protease USP7 Modulates the Replication of Kaposi's Sarcoma-Associated Herpesvirus Latent Episomal DNA

Jäger, W., Santag, S., Weidner-Glunde, M., Gellermann, E., Kati, S., Pietrek, M., Viejo‐Borbolla, A., & Schulz, T. F. (2012) · Journal of Virology · doi:10.1128/jvi.06840-11 · Cited by 65 · see citing works

Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7)

Ding, X., Jiang, W., Zhou, P., Liu, L., Wan, X., Yuan, X., Wang, X., Chen, M., Chen, J., Yang, J. C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145023 · Cited by 63 · see citing works

USP7 modulates UV-induced PCNA monoubiquitination by regulating DNA polymerase eta stability.

Qian, J., Pentz, K., Zhu, Q., Wang, Q., He, J., Srivastava, A. K., & Wani, A. A. (2015) · Oncogene · doi:10.1038/onc.2014.394 · Cited by 61 · see citing works

Expression of HAUSP in gliomas correlates with disease progression and survival of patients

Cheng, C., Niu, C., Yang, Y., Wang, Y., & Lu, M. (2013) · Oncology Reports · doi:10.3892/or.2013.2342 · Cited by 61 · see citing works

DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer.

Hernández-Pérez, S., Cabrera, E., Salido, E., Lim, M., Reid, L., Lakhani, S. R., Khanna, K. K., Saunus, J. M., & Freire, R. (2017) · Oncogene · doi:10.1038/onc.2017.21 · Cited by 61 · see citing works

Dual-utility NLS drives RNF169-dependent DNA damage responses

An, L., Jiang, Y., Ng, H. H. W., Man, E. P. S., Chen, J., Khoo, U., Gong, Q., & Huen, M. S. Y. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616602114 · Cited by 60 · see citing works

USP7 Cooperates with SCML2 To Regulate the Activity of PRC1

Lecona, E., Narendra, V. K., & Reinberg, D. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.01197-14 · Cited by 59 · see citing works

HAUSP , a novel deubiquitinase for Rb – MDM 2 the critical regulator

Bhattacharya, S., & Ghosh, M. K. (2014) · FEBS Journal · doi:10.1111/febs.12843 · Cited by 57 · see citing works

Structure of USP7 catalytic domain and three Ubl-domains reveals a connector α-helix with regulatory role

Kim, R. Q., van Dijk, W. J., & Sixma, T. K. (2016) · Journal of Structural Biology · doi:10.1016/j.jsb.2016.05.005 · Cited by 56 · see citing works

Generation and Validation of Intracellular Ubiquitin Variant Inhibitors for USP7 and USP10

Zhang, W., Sartori, M. A., Makhnevych, T., Federowicz, K., Dong, X., Liu, L., Nim, S., Dong, A., Yang, J., Li, Y., et al. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.05.025 · Cited by 56 · see citing works

Further insight into substrate recognition by USP7: structural and biochemical analysis of the HdmX and Hdm2 interactions with USP7.

Sarkari, F., La Delfa, A., Arrowsmith, C. H., Frappier, L., Sheng, Y., & Saridakis, V. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.08.017 · Cited by 54 · see citing works

USP7 deubiquitinase controls HIV-1 production by stabilizing Tat protein

Ali, A., Raja, R., Farooqui, S. R., Ahmad, S., & Banerjea, A. C. (2017) · Biochemical Journal · doi:10.1042/bcj20160304 · Cited by 54 · see citing works

Ubiquitin-specific protease 7 expression is a prognostic factor in epithelial ovarian cancer and correlates with lymph node metastasis

Yu, N., & Ma, M. (2016) · OncoTargets and Therapy · doi:10.2147/ott.s100050 · Cited by 53 · see citing works

Deubiquitination of Chfr, a checkpoint protein, by USP7/HAUSP regulates its stability and activity

Oh, Y. M., Yoo, S. J., & Seol, J. H. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.03.193 · Cited by 52 · see citing works

Active site-targeted covalent irreversible inhibitors of USP7 impair the functions of Foxp3+ T-regulatory cells by promoting ubiquitination of Tip60

Wang, F., Wang, L., Wu, J., Sokirniy, I., Nguyen, P., Bregnard, T. A., Weinstock, J., Mattern, M. R., Bezsonova, I., Hancock, W. W., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0189744 · Cited by 52 · see citing works

Identification of Kaposi Sarcoma Herpesvirus (KSHV) vIRF1 Protein as a Novel Interaction Partner of Human Deubiquitinase USP7

Chavoshi, S., Egorova, O., Lacdao, I. K., Farhadi, S., Sheng, Y., & Saridakis, V. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.710632 · Cited by 49 · see citing works

Trip12 is an E3 ubiquitin ligase for USP 7/ HAUSP involved in the DNA damage response

Liu, X., Yang, X., Li, Y., Zhao, S., Li, C., Ma, P., & Mao, B. (2016) · FEBS Letters · doi:10.1002/1873-3468.12471 · Cited by 49 · see citing works

Ubiquitin-specific Protease 7 Is a Regulator of Ubiquitin-conjugating Enzyme UbE2E1

Sarkari, F., Wheaton, K., Delfa, A. L., Mohamed, M., Shaikh, F., Khatun, R., Arrowsmith, C. H., Frappier, L., Saridakis, V., & Sheng, Y. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.469262 · Cited by 47 · see citing works

Proteome Changes Induced by Knock-Down of the Deubiquitylating Enzyme HAUSP/USP7

Kessler, B. M., Fortunati, E., Melis, M. H. M., Pals, C. E. G. M., Clevers, H. C., & Maurice, M. M. (2007) · Journal of Proteome Research · doi:10.1021/pr0702161 · Cited by 47 · see citing works

A Ubiquitin-specific Protease Possesses a Decisive Role for Adenovirus Replication and Oncogene-mediated Transformation

Ching, W., Koyuncu, E., Singh, S. K., Arbelo-Roman, C., Härtl, B., Kremmer, E., Speiseder, T., Meier, C., & Dobner, T. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003273 · Cited by 47 · see citing works

SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilizationPreprint

Yi, P., Xia, W., Wu, R., Lonard, D. M., Hung, M., & O’Malley, B. W. (2013) · Genes & Development · doi:10.1101/gad.203760.112 · Cited by 46 · see citing works

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity.

Kim, R. Q., Geurink, P. P., Mulder, M. P. C., Fish, A., Ekkebus, R., El Oualid, F., van Dijk, W. J., van Dalen, D., Ovaa, H., van Ingen, H., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-08231-5 · Cited by 41 · see citing works

BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage.

Biswas, K., Philip, S., Yadav, A., Martin, B. K., Burkett, S., Singh, V., Babbar, A., North, S. L., Chang, S., & Sharan, S. K. (2018) · Nature Communications · doi:10.1038/s41467-018-03020-6 · Cited by 41 · see citing works

Structural Characterization of Interaction between Human Ubiquitin-specific Protease 7 and Immediate-Early Protein ICP0 of Herpes Simplex Virus-1

Pozhidaeva, A., Mohni, K. N., Dhe‐Paganon, S., Arrowsmith, C. H., Weller, S. K., Korzhnev, D. M., & Bezsonova, I. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.664805 · Cited by 40 · see citing works

USP7S-dependent inactivation of Mule regulates DNA damage signalling and repair

Khoronenkova, S. V., & Dianov, G. L. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1359 · Cited by 39 · see citing works

A 2.2 Å resolution structure of the USP7 catalytic domain in a new space group elaborates upon structural rearrangements resulting from ubiquitin binding

Molland, K. L., Zhou, Q., & Mesecar, A. D. (2014) · Acta Crystallographica Section F Structural Biology Communications · doi:10.1107/s2053230x14002519 · Cited by 36 · see citing works

USP7 regulates the stability and function of HLTF through deubiquitination.

Qing, P., Han, L., Bin, L., Yan, L., & Ping, W. X. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23317 · Cited by 35 · see citing works

USP7 protects genomic stability by regulating Bub3.

Giovinazzi, S., Sirleto, P., Aksenova, V., Morozov, V. M., Zori, R., Reinhold, W. C., & Ishov, A. M. (2014) · Oncotarget · doi:10.18632/oncotarget.1989 · Cited by 34 · see citing works

Daxx is reciprocally regulated by Mdm2 and Hausp

Tang, J., Qu, L., Pang, M., & Yang, X. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.051 · Cited by 34 · see citing works

Herpesvirus-associated Ubiquitin-specific Protease (HAUSP) Modulates Peroxisome Proliferator-activated Receptor γ (PPARγ) Stability through Its Deubiquitinating Activity

Lee, K. W., Cho, J. G., Kim, C. M., Kang, A. Y., Kim, M., Ahn, B. Y., Chung, S. S., Lim, K., Baek, K., Sung, J.-H., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.496331 · Cited by 33 · see citing works

The Shelterin Component TPP1 Is a Binding Partner and Substrate for the Deubiquitinating Enzyme USP7

Zemp, I., & Lingner, J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.596056 · Cited by 28 · see citing works

Molecular mechanism for the substrate recognition of USP7

Cheng, J., Li, Z., Gong, R., Fang, J., Yang, Y., Sun, C., Yang, H., & Xu, Y. (2015) · Protein & Cell · doi:10.1007/s13238-015-0192-y · Cited by 27 · see citing works

Structural Basis of the Recruitment of Ubiquitin-specific Protease USP15 by Spliceosome Recycling Factor SART3

Zhang, Q., Harding, R., Hou, F., Dong, A., Walker, J. R., Bteich, J., & Tong, Y. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.740787 · Cited by 27 · see citing works

MBD4 Interacts With and Recruits USP7 to Heterochromatic Foci

Meng, H., Harrison, D. J., & Meehan, R. R. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25001 · Cited by 23 · see citing works

USP7/HAUSP: A SUMO deubiquitinase at the heart of DNA replication

Smits, V. A. J., & Freire, R. (2016) · BioEssays · doi:10.1002/bies.201600096 · Cited by 18 · see citing works

The ubiquitin specific protease-4 (USP4) interacts with the S9/Rpn6 subunit of the proteasome

Zhao, B., Velasco, K., Sompallae, R. R., Pfirrmann, T., Masucci, M. G., & Lindsten, K. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.09.075 · Cited by 10 · see citing works

Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and oxidative stress response

Snyder, N. A., & Silva, G. M. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101077 · Cited by 352 · see citing works

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System

Jia, J., Bissa, B., Brecht, L., Allers, L., Choi, S. W., Gu, Y., Zbinden, M., Burge, M. R., Timmins, G. S., Hallows, K. R., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2019.12.028 · Cited by 194 · see citing works

Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies

Kciuk, M., Marciniak, B., Mojzych, M., & Kontek, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197264 · Cited by 168 · see citing works

Regulation of Wnt Signaling through Ubiquitination and Deubiquitination in Cancers

Park, H., Kim, J.-W., & Baek, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113904 · Cited by 166 · see citing works

Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development

Hu, L., Li, H., Zi, M., Li, W., Liu, J., Yang, Y., Zhou, D., Kong, Q., Zhang, Y., & He, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.822816 · Cited by 167 · see citing works

Targeting USP7-Mediated Deubiquitination of MDM2/MDMX-p53 Pathway for Cancer Therapy: Are We There Yet?

Qi, S., Cheng, G., Cheng, X., Xu, Z., Xu, B., Zhang, W., & Qin, J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00233 · Cited by 162 · see citing works

Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy

Zhang, X.-W., Feng, N., Liu, Y.-C., Guo, Q., Wang, J., Bai, Y.-Z., Ye, X., Yang, Z., Yang, H., Liu, Y., et al. (2022) · Science Advances · doi:10.1126/sciadv.abo0789 · Cited by 120 · see citing works

Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity

He, Y., Li, W., Lv, D., Zhang, X., Zhang, X., Ortiz, Y. T., Budamagunta, V., Campisi, J., Zheng, G., & Zhou, D. (2020) · Aging Cell · doi:10.1111/acel.13117 · Cited by 115 · see citing works

Parthenolide inhibits ubiquitin-specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth

Li, X., Kong, L., Yang, Q., Duan, A., Ju, X., Cai, B., Chen, L., An, T., & Li, Y. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011396 · Cited by 91 · see citing works

The emerging nature of Ubiquitin-specific protease 7 (USP7): a new target in cancer therapy

Nininahazwe, L., Liu, B., He, C., Zhang, H., & Chen, Z. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.10.028 · Cited by 92 · see citing works

m6A eraser FTO impairs gemcitabine resistance in pancreatic cancer through influencing NEDD4 mRNA stability by regulating the PTEN/PI3K/AKT pathway

Lin, K., Zhou, E., Shi, T., Zhang, S., Zhang, J., Zheng, Z., Pan, Y., Gao, W., & Yu, Y. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02792-0 · Cited by 91 · see citing works

Molecular Mechanisms of DUBs Regulation in Signaling and Disease

Li, Y., & Reverter, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22030986 · Cited by 82 · see citing works

Post-Translational Modifications of Deubiquitinating Enzymes: Expanding the Ubiquitin Code

Wang, Y., & Wang, F. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.685011 · Cited by 77 · see citing works

Enhanced Live‐Cell Delivery of Synthetic Proteins Assisted by Cell‐Penetrating Peptides Fused to DABCYL

Mandal, S., Mann, G., Gandhesiri, S., & Brik, A. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202016208 · Cited by 70 · see citing works

Regulation of EZH2 protein stability: new mechanisms, roles in tumorigenesis, and roads to the clinic

Guo, Y., Cheng, R., Wang, Y., Gonzalez, M. E., Zhang, H., Liu, Y., Kleer, C. G., & Xue, L. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.104972 · Cited by 55 · see citing works

The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-ĸB subunits

Mitxitorena, I., Somma, D., Mitchell, J. P., Lepistö, M., Tyrchan, C., Smith, E., Kiely, P. A., Walden, H., Keeshan, K., & Carmody, R. J. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.014113 · Cited by 51 · see citing works

Recent advances on the intervention sites targeting USP7-MDM2-p53 in cancer therapy

Harakandi, C., Nininahazwe, L., Xu, H., Liu, B., He, C., Zheng, Y., & Zhang, H. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.105273 · Cited by 52 · see citing works

Targeting the MYC Ubiquitination-Proteasome Degradation Pathway for Cancer Therapy

Sun, X., Li, Y., Sears, R. C., & Dai, M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.679445 · Cited by 49 · see citing works

Ubiquitin-specific proteases in inflammatory bowel disease-related signalling pathway regulation

Chen, R., Pang, X., Li, L., Zeng, Z., Chen, M., & Zhang, S. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04566-6 · Cited by 48 · see citing works

Recent advances in the development of ubiquitin-specific-processing protease 7 (USP7) inhibitors

Li, P., & Liu, H.-M. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112107 · Cited by 48 · see citing works

Ubiquitin-specific protease 7 regulates myocardial ischemia/reperfusion injury by stabilizing Keap1

Xu, Q., Liu, M., Gu, J., Ling, S., Liu, X., Luo, Z., Jin, Y., Chai, R., Ou, W., Liu, S., et al. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01086-2 · Cited by 46 · see citing works

The deubiquitinase USP7 regulates oxidative stress through stabilization of HO-1

Gao, M., Qi, Z., Deng, M., Huang, H., Xu, Z., Guo, G., Jing, J., Huang, X., Xu, M., Kloeber, J. A., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02403-w · Cited by 46 · see citing works

Spotlight on USP4: Structure, Function, and Regulation

Hu, B., Zhang, D., Zhao, K., Wang, Y., Pei, L., Fu, Q., & Ma, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.595159 · Cited by 45 · see citing works

USP7 deubiquitinates KRAS and promotes non-small cell lung cancer

Huang, B., Cao, D., Yuan, X., Xiong, Y., Chen, B., Wang, Y., Niu, X., Tian, R., & Huang, H. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114917 · Cited by 46 · see citing works

USP7 Inhibitors in Cancer Immunotherapy: Current Status and Perspective

Korenev, G., Yakukhnov, S., Druk, A., Golovina, A., Chasov, V. V., Mirgayazova, R., Ivanov, R. A., & Bulatov, E. (2022) · Cancers · doi:10.3390/cancers14225539 · Cited by 41 · see citing works

Small molecules that target the ubiquitin system

Wu, H. Q., Baker, D. A., & Ovaa, H. (2020) · Biochemical Society Transactions · doi:10.1042/bst20190535 · Cited by 41 · see citing works

Ubiquitin-specific protease 7 (USP7): an emerging drug target for cancer treatment

Carreira, L. D., Oliveira, R. I., Moreira, V. M., & Salvador, J. A. R. (2023) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2023.2266571 · Cited by 41 · see citing works

Mechanisms orchestrating the enzymatic activity and cellular functions of deubiquitinases

Estavoyer, B., Messmer, C., Echbicheb, M., Rudd, C. E., Milot, É., & Affar, E. B. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102198 · Cited by 37 · see citing works

USP7 regulates HMOX-1 via deubiquitination to suppress ferroptosis and ameliorate spinal cord injury in rats

Wang, C., Zhu, Y., Zhu, X., Chen, R., Zhang, X., & Lian, N. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105554 · Cited by 36 · see citing works

Deubiquitinases in hematological malignancies

Lei, H., Wang, J., Hu, J., Zhu, Q., & Wu, Y. (2021) · Biomarker Research · doi:10.1186/s40364-021-00320-w · Cited by 35 · see citing works

Current and future directions of USP7 interactome in cancer study

Park, H., & Baek, K. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188992 · Cited by 35 · see citing works

USP7, negatively regulated by miR‐409‐5p, aggravates hypoxia‐induced cardiomyocyte injury

Xue, Q., Yang, D. M., Zhang, J., Gan, P., Lin, C., Lu, Y., Zhang, W., Zhang, L., & Guang, X. (2020) · Apmis · doi:10.1111/apm.13100 · Cited by 34 · see citing works

Emerging role of ubiquitination/deubiquitination modification of PD-1/PD-L1 in cancer immunotherapy

Ding, P., Ma, Z., Fan, Y., Feng, Y., Shao, C., Pan, M., Zhang, Y., Huang, D., Han, J. Y., Hu, Y., et al. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2022.01.002 · Cited by 35 · see citing works

USP7 manipulation by viral proteins

Bojagora, A., & Saridakis, V. (2020) · Virus Research · doi:10.1016/j.virusres.2020.198076 · Cited by 33 · see citing works

Targeting protein–protein interactions in the DNA damage response pathways for cancer chemotherapy

McPherson, K. S., & Korzhnev, D. M. (2021) · RSC Chemical Biology · doi:10.1039/d1cb00101a · Cited by 33 · see citing works

Design, synthesis, biological evaluation and structure-activity relationship study of quinazolin-4(3H)-one derivatives as novel USP7 inhibitors

Li, P., Liu, Y., Yang, H., & Liu, H.-M. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113291 · Cited by 30 · see citing works

USP7 promotes hepatoblastoma progression through activation of PI3K/AKT signaling pathway

Ye, M., He, J., Zhang, J., Liu, B., Liu, X., Xie, L., Wei, M., Dong, R., Li, K., Ma, D., et al. (2021) · Cancer Biomarkers · doi:10.3233/cbm-200052 · Cited by 29 · see citing works

Discovery of Ubiquitin-Specific Protease 7 (USP7) Inhibitors with Novel Scaffold Structures by Virtual Screening, Molecular Dynamics Simulation, and Biological Evaluation

Liu, S., Zhou, X., Li, M., Zhao, W., Zhou, S., Cheng, K., Xu, Q., Chen, C., Wen, X., Sun, H., et al. (2020) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.0c00154 · Cited by 28 · see citing works

USP7 Attenuates Endoplasmic Reticulum Stress and NF‐ κ B Signaling to Modulate Chondrocyte Proliferation, Apoptosis, and Inflammatory Response under Inflammation

Dong, X., Yang, C., Luo, Y., Dong, W., Xu, X., Wu, Y., & Wang, J. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1835900 · Cited by 26 · see citing works

UBP12 and UBP13 deubiquitinases destabilize the CRY2 blue light receptor to regulate Arabidopsis growth

Norén, L., Hu, Y., Ackermann, A., Artz, O., & Pedmale, U. V. (2022) · Current Biology · doi:10.1016/j.cub.2022.05.046 · Cited by 24 · see citing works

USP7 promotes the osteoclast differentiation of CD14+ human peripheral blood monocytes in osteoporosis via HMGB1 deubiquitination

Lin, Y., Zheng, G. H., Liu, H., Wang, P., Yuan, W.-Q., Zhang, Y., Peng, X., Li, G.-J., Wu, Y., & Shen, H. (2023) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2023.05.007 · Cited by 24 · see citing works

Prostate Cancer Cells Secrete PD-1 in Exosomes to Enhance Myeloid-Derived Suppressor Cell Activity and Promote Tumor Immune Evasion

Zhang, J., Chen, W., Zhang, C., He, Q., Wang, X., Han, J., Gao, P., Wang, K., Xie, H., Gao, F., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-3748 · Cited by 24 · see citing works

Ubiquitin-Specific Peptidase 7: A Novel Deubiquitinase That Regulates Protein Homeostasis and Cancers

Zhou, L., Ouyang, T., Li, M., Hong, T., Alriashy, M. H. S., Meng, W., & Zhang, N. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.784672 · Cited by 23 · see citing works

Cigarette smoke extract mediates cell premature senescence in chronic obstructive pulmonary disease patients by up-regulating USP7 to activate p300-p53/p21 pathway

Zeng, M., Zhang, X., Xing, W., Wang, Q., Liang, G.-B., & He, Z. (2022) · Toxicology Letters · doi:10.1016/j.toxlet.2022.01.017 · Cited by 23 · see citing works

De-ubiquitination of SAMHD1 by USP7 promotes DNA damage repair to overcome oncogenic stress and affect chemotherapy sensitivity

Liu, J., Zhou, T., Dong, X. D., Guo, Q., Zheng, L., Wang, X., Zhang, N., Li, D., Ren, L., Yi, F., et al. (2023) · Oncogene · doi:10.1038/s41388-023-02667-w · Cited by 23 · see citing works

USP7 substrates identified by proteomics analysis reveal the specificity of USP7Preprint

Nie, L., Wang, C., Liu, X., Teng, H., Li, S., Huang, M., Feng, X., Pei, G., Hang, Q., Zhao, Z., et al. (2022) · Genes & Development · doi:10.1101/gad.349848.122 · Cited by 24 · see citing works

USP7 promotes cardiometabolic disorders and mitochondrial homeostasis dysfunction in diabetic mice via stabilizing PGC1β

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LINC01088 prevents ferroptosis in glioblastoma by enhancing SLC7A11 via HLTF/USP7 axis

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piRNA mmu_piR_037459 suppression alleviated the degeneration of chondrocyte and cartilage

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Ubiquitin-Specific Protease 7 (USP7) as a Promising Therapeutic Target for Drug Discovery: From Mechanisms to Therapies

Song, Y., Ren, X., Xiong, J., Wang, W., Zhao, Q., Chang, J., & Yu, B. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c00102 · Cited by 22 · see citing works

The Role of DNA Viruses in Human Cancer

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E3 ligases and DUBs target ferroptosis: A potential therapeutic strategy for neurodegenerative diseases

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DNA Polymerase ι Interacts with Both the TRAF-like and UBL1-2 Domains of USP7

Ashton, N. W., Valles, G. J., Jaiswal, N., Bezsonova, I., & Woodgate, R. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.166733 · Cited by 18 · see citing works

On the Study of Deubiquitinases: Using the Right Tools for the Job

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UBR5 Acts as an Antiviral Host Factor against MERS-CoV via Promoting Ubiquitination and Degradation of ORF4b

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The emerging role of Deubiquitinases (DUBs) in parasites: A foresight review

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Targeted therapy for cisplatin‐resistant lung cancer via aptamer‐guided nano‐zinc carriers containing USP14 siRNA

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Therapeutic targeting of ubiquitin-specific protease 7 (USP7): Mechanistic insights, dysregulation, and advances in drug discovery

El-Hamaky, A. A., El‐Hamamsy, M. H., El-Moselhy, T. F., Sharafeldin, N., & Tawfik, H. O. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.117872 · Cited by 17 · see citing works

Recent advances in the pharmacological targeting of ubiquitin-regulating enzymes in cancer

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YM155 inhibits neuroblastoma growth through degradation of MYCN: A new role as a USP7 inhibitor

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Identification of YCH2823 as a novel USP7 inhibitor for cancer therapy

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mTORC1 accelerates osteosarcoma progression via m6A-dependent stabilization of USP7 mRNA

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The emerging roles of deubiquitinases in plant proteostasis

Skelly, M. J. (2022) · Essays in Biochemistry · doi:10.1042/ebc20210060 · Cited by 15 · see citing works

Targeting senescent cells in atherosclerosis: Pathways to novel therapies

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Inhibition of USP7 upregulates USP22 and activates its downstream cancer-related signaling pathways in human cancer cells

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Deubiquitinating Enzyme USP7 Is Required for Self-Renewal and Multipotency of Human Bone Marrow-Derived Mesenchymal Stromal Cells

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Oxyberberine sensitizes liver cancer cells to sorafenib via inhibiting NOTCH1-USP7-c-Myc pathway

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USP7 Inhibitors Destabilize EBNA1 and Suppress Epstein‐Barr Virus Tumorigenesis

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Design, synthesis and biological evaluation of 2-aminopyridine derivatives as USP7 inhibitors

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Insights into a functional model of key deubiquitinases UBP12 /13 in plants

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P53 upregulation by USP7-engaging molecular glues

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Inhibition of ubiquitin-specific protease 7 ameliorates ferroptosis-mediated myocardial infarction by contrasting oxidative stress: An in vitro and in vivo analysis

Yang, D., Zhang, T., Qu, H. Y., Li, S., Lu, J., Cao, W., Chen, Z., Zhang, H., Yang, J., & Wang, J. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111423 · Cited by 11 · see citing works

Targeted therapy based on ubiquitin-specific proteases, signalling pathways and E3 ligases in non-small-cell lung cancer

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Intracellular spatiotemporal metabolism in connection to target engagement

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Non-canonical regulation of the reactivation of an oncogenic herpesvirus by the OTUD4-USP7 deubiquitinases

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The role of USP7 in the Shoc2-ERK1/2 signaling axis and Noonan-like syndrome with loose anagen hair

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Involvement of USP7 in aggravating Kawasaki disease by promoting TGFβ2 signaling mediated endothelial-mesenchymal transition and coronary artery remodeling

Qian, G., Wang, Y., Yao, H., Zhang, Z.-M., Wang, W., Xu, L., Li, W., Huang, L., Li, X., Gao, Y., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113823 · Cited by 9 · see citing works

Unraveling the role of deubiquitinating enzymes on cisplatin resistance in several cancers

Jin, S.-K., & Baek, K. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189297 · Cited by 9 · see citing works

Activation dynamics of ubiquitin-specific protease 7

Valles, G. J., Korchak, E. J., Geddes-Buehre, D. H., Jaiswal, N., Korzhnev, D. M., & Bezsonova, I. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2426632122 · Cited by 9 · see citing works

Discovery of pyrrolo[2,3-d]pyrimidin-4-one derivative YCH3124 as a potent USP7 inhibitor for cancer therapy

Zhuang, Z., Miao, Y.-L., Song, S., Leng, G.-T., Zhang, X., He, Q., Ding, J., He, J., & Yang, C. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116752 · Cited by 9 · see citing works

USP7 protects TFEB from proteasome-mediated degradation

Keshri, S., Vicinanza, M., Takla, M., & Rubinsztein, D. C. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114872 · Cited by 8 · see citing works

The Role and Mechanism of Deubiquitinase USP7 in Tumor-Associated Inflammation

Wang, L., Zhang, Y., Yu, T., & Wu, H. (2024) · Biomedicines · doi:10.3390/biomedicines12122734 · Cited by 8 · see citing works

Mechanistic Insights into the Mechanism of Allosteric Inhibition of Ubiquitin-Specific Protease 7 (USP7)

Wang, X., Liu, N., Li, N., Lu, S., & Chai, Z. (2025) · Biomolecules · doi:10.3390/biom15060749 · Cited by 8 · see citing works

Ribonucleotide reductase holoenzyme inhibitor COH29 interacts with deubiquitinase ubiquitin‐specific protease 2 and downregulates its substrate protein cyclin D1

Zhu, M., Wang, H., Ding, Y., Yang, Y., Xu, Z., Li, S., & Zhang, N. (2022) · The FASEB Journal · doi:10.1096/fj.202101914rr · Cited by 8 · see citing works

Deubiquitinating Enzymes Orchestrate the Cancer Stem Cell-Immunosuppressive Niche Dialogue: New Perspectives and Therapeutic Potential

Guo, J., Xia, B.-R., Deng, S.-H., Yang, C. Q., Pi, Y., Cui, B., & Jin, W. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.680100 · Cited by 8 · see citing works

Virtual Screening Inhibitors of Ubiquitin‐specific Protease 7 Combining Pharmacophore Modeling and Molecular Docking

Zhang, S., Wang, Y., Liu, L., Zhao, G., Sun, Y., Wang, J., Liu, F., Wang, P., & Xu, X. (2022) · Molecular Informatics · doi:10.1002/minf.202100273 · Cited by 8 · see citing works

Phosphorylation of USP27X by GSK3β maintains the stability and oncogenic functions of CBX2

Xing, Y.-S., Ba-tu, J., Dong, C., Cao, X., Li, B., Jia, X., Juan, Y., Lv, X., Zhang, H., Qin, N., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06304-y · Cited by 8 · see citing works

USP7-stabilised HIPK2 promotes high glucose-induced endothelial cell dysfunctions to accelerate diabetic foot ulcers

Huang, H., & Huang, Y. (2024) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2024.2376815 · Cited by 7 · see citing works

Protein modification regulated autophagy in Bombyx mori and Drosophila melanogaster

Wu, W., Lin, L., Zhao, Y., Li, H., & Zhang, R. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1281555 · Cited by 7 · see citing works

USP7 alleviates neuronal inflammation and apoptosis in spinal cord injury via deubiquitinating NRF1/KLF7 axis

Xu, Q., Kong, F., Zhao, G., Jin, J., Feng, S., & Li, M. (2024) · Neurological Research · doi:10.1080/01616412.2024.2376999 · Cited by 7 · see citing works

Enhanced Live‐Cell Delivery of Synthetic Proteins Assisted by Cell‐Penetrating Peptides Fused to DABCYL

Mandal, S., Mann, G., Gandhesiri, S., & Brik, A. (2021) · Angewandte Chemie · doi:10.1002/ange.202016208 · Cited by 7 · see citing works

Protein phosphatase 2A regulated by USP7 is polyubiquitinated and polyneddylated

Do, H., & Baek, K. (2022) · Oncology Reports · doi:10.3892/or.2022.8335 · Cited by 7 · see citing works

Repurposing of US-FDA-approved drugs as negative modulators of ubiquitin specific protease-7 (USP7)

Zadi, S., Javaid, S., Wahab, A., Zafar, H., Awais, M., Maslennikov, I., & Choudhary, M. I. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e26345 · Cited by 7 · see citing works

Circulating microRNA-409-5p and USP7 are associated with left ventricular remodeling in patients with acute myocardial infarction

He, G.-P., Sha, S., He, J., Zhang, X., Jin, Q., Zhao, T., Jin, S., Shrestha, N., Li, H., Qiu, C., et al. (2024) · BMC Cardiovascular Disorders · doi:10.1186/s12872-024-04299-8 · Cited by 6 · see citing works

USP7 V517F mutation as a mechanism of inhibitor resistance

Miao, Y.-L., Fan, F., Cheng, Y.-J., Li, J., Song, S., Huan, X., Bao, X., Ding, J., Yu, X., & He, J. (2025) · Nature Communications · doi:10.1038/s41467-025-56981-w · Cited by 6 · see citing works

Mechanisms of action of ubiquitin-specific proteases, particularly ubiquitin-specific proteases 7, 8, and 25, in depression treatment

Zhang, Y., Guan, W., & Miao, Y. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117085 · Cited by 6 · see citing works

Nucleosomes specify co-factor access to p53

Chakraborty, D., Sandate, C. R., Isbel, L., Kempf, G., Weiss, J., Cavadini, S., Kater, L., Seebacher, J., Kozicka, Z., Stoos, L., et al. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.06.027 · Cited by 5 · see citing works

USP7 at the Crossroads of Ubiquitin Signaling, Cell Cycle, and Tumorigenesis

Lusardi, M., Rapetti, F., Spallarossa, A., Massone, M., Cichero, E., & Brullo, C. (2025) · Molecules · doi:10.3390/molecules30204038 · Cited by 6 · see citing works

Small-molecule allosteric activator of ubiquitin-specific protease 7 (USP7)

Maisonet, I. J., Sharafi, M., Korchak, E. J., Salazar‐Chaparro, A. F., Bratt, A. S., Parikh, T., Varca, A. C., Shah, B., Darnowski, M. G., Chung, M., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2510496122 · Cited by 6 · see citing works

USP7-mediated deubiquitination of the KEAP1-NRF2-HMOX1 axis enhances radioresistance in non-small cell lung cancer by suppressing ferroptosis

Tang, J., Xu, L., Gong, Z., & Chen, L. (2026) · Oncogene · doi:10.1038/s41388-026-03783-z · Cited by 6 · see citing works

Recent insights into USP7: Construct, pathophysiology, and inhibitors

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The emerging nature of Ubiquitin-specific protease 7 (USP7): a new target in cancer therapy

Nininahazwe, L., Liu, B., He, C., Zhang, H., & Chen, Z. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.10.028 · Cited by 92 · see citing works

USP7: Target Validation and Drug Discovery for Cancer Therapy

Zhou, J., Wang, J., Chen, C., Yuan, H., Wen, X., & Sun, H. (2018) · Medicinal Chemistry · doi:10.2174/1573406413666171020115539 · Cited by 100 · see citing works

USP7: Novel Drug Target in Cancer Therapy

Wang, Z., Kang, W.-T., You, Y., Pang, J., Ren, H., Suo, Z., Liu, H., & Zheng, Y. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00427 · Cited by 124 · see citing works

Recent advances in the development of ubiquitin-specific-processing protease 7 (USP7) inhibitors

Li, P., & Liu, H.-M. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112107 · Cited by 48 · see citing works