Reactions and enzymes in the metabolism of drugs and other xenobiotics

Cited by (255)

Items 101–200 of 255

1. Prediction of UGT-mediated Metabolism Using the Manually Curated MetaQSAR Database
   Angelica Mazzolari, Avid M. Afzal, Alessandro Pedretti, Bernard Testa, Giulio Vistoli, Andreas Bender · 2019 · ACS Medicinal Chemistry Letters
2. 3,5-Dimethyl-4-isoxazoyl selenocyanate as promising agent for the treatment of Leishmania infantum-infected mice
   Verónica Alcolea, Esther Moreno, Mikel Etxebeste-Mitxeltorena, Í. Navarro-Blasco, Elena González‐Peñas, Antonio Jiménez-Ruı́z, Juan M. Irache, Carmen Sanmartín, Socorro Espuelas · 2020 · Acta Tropica
3. Convolutional neural network prediction of molecular properties for aerosol chemistry and health effects
   Matteo Krüger, Jake Wilson, Marco Wietzoreck, Benjamin A. Musa Bandowe, Gerhard Lammel, Bertil Schmidt, Ulrich Pöschl, Thomas Berkemeier · 2022 · Natural Sciences
4. Substrate Selectivity of Coumarin Derivatives by Human CYP1 Enzymes: In Vitro Enzyme Kinetics and In Silico Modeling
   Risto Olavi Juvonen, Mira Ahinko, Elmeri M. Jokinen, Juhani Huuskonen, Hannu Raunio, Olli T. Pentikäinen · 2021 · ACS Omega
5. MurineCyp3aknockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans
   Naoyuki Nakada, Akio Kawamura, Hidetaka Kamimura, Koya Sato, Yasuhiro Kazuki, Masakazu Kakuni, Masato Ohbuchi, Kota Kato, Chise Tateno, Mitsuo Oshimura et al. · 2015 · Biopharmaceutics & Drug Disposition
6. Transcriptome profile of Haemaphysalis longicornis (Acari: Ixodidae) exposed to Cymbopogon citratus essential oil and citronellal suggest a cytotoxic mode of action involving mitochondrial Ca2+ overload and depolarization
   Desmond Onyeka Agwunobi, Meng Zhang, Xiaojing Zhang, Tongxuan Wang, Zhijun Yu, Jingze Liu · 2021 · Pesticide Biochemistry and Physiology
7. Quantitative structure activity relationship and molecular simulations for the exploration of natural potent VEGFR-2 inhibitors: an in silico anti-angiogenic study
   Neha Sharma, Mala Sharma, Qazi Inamur Rahman, Salman Akhtar, Mohd. Muddassir · 2020 · Journal of Biomolecular Structure and Dynamics
8. Advancing ADMET prediction for major CYP450 isoforms: graph-based models, limitations, and future directions
   Asmaa A. Abdelwahab, Mustafa Elattar, Sahar Ali Fawzi · 2025 · BioMedical Engineering OnLine
9. In Vitro Glucuronidation of Caribbean Ciguatoxins in Fish: First Report of Conjugative Ciguatoxin Metabolites
   Jessica Kay Gwinn, Silvio Uhlig, Lada Ivanova, Christiane Kruse Fæste, Fedor Kryuchkov, Alison Robertson · 2021 · Chemical Research in Toxicology
10. Prediction of cytochrome P450-mediated bioactivation using machine learning models and in vitro validation
    Xin-Man Hu, Yan-Yao Hou, Xin-Ru Teng, Yong Liu, Yu Li, Wěi Li, Yan Li, Chun‐Zhi Ai · 2024 · Archives of Toxicology
11. XMetDB: an open access database for xenobiotic metabolism
    Ola Spjuth, Patrik Rydberg, Egon Willighagen, Chris T. Evelo, Nina Jeliazkova · 2016 · Journal of Cheminformatics
12. In-depth understanding of the structure-based reactive metabolite formation of organic functional groups
    Chunyong He, Yuchang Mao, Hong Wan · 2025 · Drug Metabolism Reviews
13. Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarinviahuman CYP2A6 and its mouse and pig orthologous enzymes
    Risto Olavi Juvonen, Mira Kuusisto, Carolin Fohrgrup, Mari H. Pitkänen, Tapio Nevalainen, Seppo O. K. Auriola, Hannu Raunio, Markku Pasanen, Olli T. Pentikäinen · 2015 · Xenobiotica
14. High-valent iron-oxo species on pyridine-containing MWCNTs generated in a solar-induced H2O2 activation system for the removal of antimicrobials
    Yun Xia, Nan Li, Wangyang Lü, Wentao Wang, Yuyuan Yao, Zhexin Zhu, Tiefeng Xu, Yan Gu, Wenxing Chen · 2021 · Chemosphere
15. Regioselective biotransformation of CNS drugs and its clinical impact on adverse drug reactions
    Yin Cheong Wong, Shuai Qian, Zhong Zuo · 2012 · Expert Opinion on Drug Metabolism & Toxicology
16. Machine Learning Models to Predict Cytochrome P450 2B6 Inhibitors and Substrates
    Longqiang Li, Lu Zhou, Guixia Liu, Yun Tang, Weihua Li · 2023 · Chemical Research in Toxicology
17. Alignment-Based Prediction of Sites of Metabolism
    Christina de Bruyn Kops, Nils‐Ole Friedrich, Johannes Kirchmair · 2017 · Journal of Chemical Information and Modeling
18. Prediction of the Formation of Reactive Metabolites by A Novel Classifier Approach Based on Enrichment Factor Optimization (EFO) as Implemented in the VEGA Program
    Angelica Mazzolari, Giulio Vistoli, Bernard Testa, Alessandro Pedretti · 2018 · Molecules
19. MetaClass, a Comprehensive Classification System for Predicting the Occurrence of Metabolic Reactions Based on the MetaQSAR Database
    Angelica Mazzolari, Alice Scaccabarozzi, Giulio Vistoli, Alessandro Pedretti · 2021 · Molecules
20. MetaSpot: A General Approach for Recognizing the Reactive Atoms Undergoing Metabolic Reactions Based on the MetaQSAR Database
    Angelica Mazzolari, Pietro Perazzoni, Emanuela Sabato, Filippo Lunghini, Andrea R. Beccari, Giulio Vistoli, Alessandro Pedretti · 2023 · International Journal of Molecular Sciences
21. Role of ADME/PK in Drug Discovery, Safety Assessment, and Clinical Development
    Ronald E. White · 2016 · Elsevier eBooks
22. Marine Invertebrate Xenobiotic-Activated Nuclear Receptors: Their Application as Sensor Elements in High-Throughput Bioassays for Marine Bioactive Compounds
    Ingrid Richter, Andrew Eric Fidler · 2014 · Marine Drugs
23. Integrative analysis of proteomic and metabonomics data for identification of pathways related to Rhizoma Paridis-induced hepatotoxicity
    Chongjun Zhao, Mingshuang Wang, Jianmei Huang, Zhe Jia, Xia Zhao, Erwen Li, Ziying Wei, Ying Dong, Wenxue Liu, Ting Han et al. · 2020 · Scientific Reports
24. Machine learning and structure-based modeling for the prediction of UDP-glucuronosyltransferase inhibition
    Bálint Dudás, Youcef Bagdad, Milan Picard, David Pérahia, Maria A. Miteva · 2022 · iScience
25. Ligand-based Pharmacophore Modeling, Molecular Docking and Simulation Studies for the Exploration of Natural Potent Antiangiogenic Inhibitors Targeting Heat Shock Protein 90
    Salman Akhtar, Neha Sharma, Mala Sharma, Mohammad Faisal, Abdulrahman Abdullah Alatar, Rajnish Kumar, Saheem Ahmad · 2022 · Letters in Drug Design & Discovery
26. Transformation Reactions of Radicals from the Oxidation of Diphenhydramine: Pulse Radiolysis and Mass Spectrometric Studies
    Sunil Paul M. Menacherry, Sreekanth R. Nair, Pramod G. Nair, Usha Kulankara Aravind, Charuvila T. Aravindakumar · 2016 · ChemistrySelect
27. Biotransformation and bioactivation reactions – 2017 literature highlights
    Siamak Cyrus Khojasteh, Grover Paul Miller, Kaushik Mitra, Ivonne M.C.M. Rietjens · 2018 · Drug Metabolism Reviews
28. Application of a molecular networking approach using LC-HRMS combined with the MetWork webserver for clinical and forensic toxicology
    Romain Magny, Yann Beauxis, Grégory Genta‐Jouve, Emmanuel Bourgogne · 2024 · Heliyon
29. Ilexsaponin A1: In vitro metabolites identification and evaluation of inhibitory drug-drug interactions
    Liang Wu, Kang An, Xiaoliang Jin, Yuqing Bao, Peng Miao, Tingmei Lv, Zhu Zhou · 2021 · Drug Metabolism and Pharmacokinetics
30. Active Learning Approach for Guiding Site-of-Metabolism Measurement and Annotation
    Ya Chen, Thomas Seidel, Roxane Axel Jacob, Steffen Hirte, Angelica Mazzolari, Alessandro Pedretti, Giulio Vistoli, Thierry Langer, Filip N. Miljković, Johannes Kirchmair · 2024 · Journal of Chemical Information and Modeling
31. In vitro metabolism studies of natural products are crucial in the early development of medicines
    Fernanda de Lima Moreira, Lucas Maciel Mauriz Marques, Norberto Peporine Lopes, Anderson Rodrigo Moraes de Oliveira · 2016 · Phytochemistry Reviews
32. Effect of copper on the translocation and transformation of polychlorinated biphenyls in rice
    Lili Pan, Jianteng Sun, X. Chris Le, Lizhong Zhu · 2017 · Chemosphere
33. Role of drug-metabolizing enzymes in biotransformation of drugs
    Azka Yaqoob, Qudsia Rehman, Kanwal Rehman, Muhammad Sajid Hamid Akash, Iqbal Hussain, Rasheed Ahmad · 2022 · Elsevier eBooks
34. Computational prediction of the metabolites of agrochemicals formed in rats
    Vincent-Alexander Scholz, Conrad Stork, Markus Frericks, Johannes Kirchmair · 2023 · The Science of The Total Environment
35. Message Passing Neural Networks Improve Prediction of Metabolite Authenticity
    Noah R. Flynn, S. Joshua Swamidass · 2023 · Journal of Chemical Information and Modeling
36. Identification of Xenobiotic Biotransformation Products Using Mass Spectrometry-Based Metabolomics Integrated with a Structural Elucidation Strategy by Assembling Fragment Signatures
    Yuan-Chih Chen, Hsin‐Yi Wu, Wei-Sheng Wu, Jen-Yi Hsu, Chih‐Wei Chang, Yuan-Han Lee, Pao‐Chi Liao · 2023 · Analytical Chemistry
37. Drug Metabolism
    Mageshwaran Lakshmanan · 2019 · Introduction to Basics of Pharmacology and Toxicology
38. Machine Learning in Drug Metabolism Study
    Krishnendu Sinha, Jyotirmoy Ghosh, Parames Chandra Sil · 2022 · Current Drug Metabolism
39. Contribution of Mass Spectrometry to the Advances in Risk Characterization of Marine Biotoxins: Towards the Characterization of Metabolites Implied in Human Intoxications
    Pablo Estévez, Ana Gago-Martı́nez · 2023 · Toxins
40. Environmental biotransformation mechanisms by flavin-dependent monooxygenase: A computational study
    Fangjie Guo, Yilin Tian, Shujing Ji, Hao Min, Wen Ding, Haiying Yu, Yingqi Li, Li Ji · 2023 · Chemosphere
41. Recent Progress in the Development of Fluorometric Chemosensors to Detect Enzymatic Activity
    Tingwen Wei, Fang Wang, Zhijie Zhang, Qiang Jiang, Jing Hui Lv, Tiantian Chen, Jia Li, Xiaoqiang Chen · 2018 · Current Medicinal Chemistry
42. Chronic administration of caderofloxacin, a new fluoroquinolone, increases hepatic CYP2E1 expression and activity in rats
    Li Liu, Mingxing Miao, Zeyu Zhong, Ping Xu, Yang Chen, Xiaodong Liu · 2016 · Acta Pharmacologica Sinica
43. Advances in drug resistance of osteosarcoma caused by pregnane X receptor
    Kunhong Mao, Can Liu, Zhongwen Tang, Zhou-Zhou Rao, Jie Wen · 2024 · Drug Metabolism Reviews
44. An exposomics analysis of 125 biomarkers of exposure to food contaminants and biomarkers of oxidative stress: a randomized cross-over chrononutrition trial of healthy adults
    Hayley Kunde, Elina Ioannou, Jasmin Chovatiya, Ravikumar Jagani, Pantelis Charisiadis, Manish Arora, Syam S. Andra, Konstantinos C. Makris · 2025 · Environment International
45. Metabolite Identification Data in Drug Discovery, Part 2: Site-of-Metabolism Annotation, Analysis, and Exploration for Machine Learning
    Ya Chen, Susanne Winiwarter, Roxane Axel Jacob, Marie M. Ahlqvist, Angelica Mazzolari, Filip N. Miljković, Johannes Kirchmair · 2025 · Molecular Pharmaceutics
46. Biochemical activation and functions of drug-metabolizing enzymes
    Anam Shabbir, Kamran Haider, Kanwal Rehman, Muhammad Sajid Hamid Akash, Shuqing Chen · 2022 · Elsevier eBooks
47. Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of protective human variants
    Michelle R. Garnsey, Yang Wang, David J. Edmonds, M. F. Sammons, Benjamin Reidich, Youngwook Ahn, Yotam Ashkenazi, Anthony A. Carlo, Matthew A. Cerny, Karen J. Coffman et al. · 2025 · Nature Communications
48. Quantifying confidence in the reporting of metabolic biotransformations
    David J. Ponting, Ernest J. Murray, Anthony Long · 2017 · Drug Discovery Today
49. Metabolism elucidation of BJ-B11 (a heat shock protein 90 inhibitor) by human liver microsomes: identification of main contributing enzymes
    Danyi Lu, Dong Dong, Zhong Liu, Yifei Wang, Baojian Wu · 2015 · Expert Opinion on Drug Metabolism & Toxicology
50. Lessons and Successes in the Use of Molecular Fields
    Paolo Tosco, M. Mackey · 2017 · Elsevier eBooks
51. Characteristics of Major Drug Metabolizing Cytochrome P450 Enzymes
    Kevin M. Johnson, Dian G. T. Su, Donglu Zhang · 2021 · Methods in pharmacology and toxicology
52. Site-of-Metabolism Prediction with Aleatoric and Epistemic Uncertainty Quantification
    Roxane Axel Jacob, Oliver Wieder, Ya Chen, Angelica Mazzolari, Andreas Bergner, Klaus-Juergen Schleifer, Johannes Kirchmair · 2025 · Journal of Chemical Information and Modeling
53. The African Liver Tissue Biorepository Consortium: Capacitating Population-Appropriate Drug Metabolism, Pharmacokinetics, and Pharmacogenetics Research in Drug Discovery and Development
    Collen Mutowembwa Masimirembwa, Michèle Ramsay, Jean Frederick Botha, Ewa C. S. Ellis, Harriet Rosanne Etheredge, Tracey Hurrell, Comfort Ropafadzo Kanji, Nyasha Nicole Kapungu, Heather Maher, Busisiwe Mthembu et al. · 2023 · Drug Metabolism and Disposition
54. Pharmaceutical Bioinformatics: Its Relevance to Drug Metabolism
    Chika John Mbah, Ndidiamaka Hannah Okorie · 2019 · Madridge Journal of Bioinformatics and Systems Biology
55. Discovery of benzyloxyphenyl- and phenethylphenyl-imidazole derivatives as a new class of ante–drug type boosters
    Kentaro Kawai, Jun Okada, Mizuki Nakae, Toshiki Tsujimura, Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Shinji Yamashita, Makoto Kataoka, Masaaki Omote · 2022 · Bioorganic & Medicinal Chemistry Letters
56. Recent Advances in Hepatic Metabolic Regulation by the Nuclear Factor Rev-erbɑ
    Qi Zhang, Yutong Chen, Jingqi Li, Haishan Xia, Yongbin Tong, Yuyu Liu · 2024 · Current Drug Metabolism
57. Identification of selective inhibitors of uridine 5'-diphospho-glucuronosyltransferase (UGT) 1A3 and UGT1A8 and their application in UGT reaction phenotyping studies in human liver and intestinal microsomes
    Ting Wang, Alyssa P Anderson, Andrew S. Yu, Mitchell E. Taub, Tom S. Chan · 2025 · Drug Metabolism and Disposition
58. Artificial intelligence and computational methods in human metabolism research: A comprehensive survey
    Manzhan Zhang, Yuxin Wan, Jing Wang, Shiliang Li, Honglin Li · 2025 · Journal of Pharmaceutical Analysis
59. MuMCyp_Net: A multimodal neural network for the prediction of Cyp450 inhibition
    Soualihou Ngnamsie Njimbouom, Jeong‐Dong Kim · 2024 · Expert Systems with Applications
60. Transcriptome analysis of Reticulitermes flaviceps exposed to Mentha spicata essential oil and carvone indicates a potential neurotoxic mechanism of action characterized by intracellular calcium influx mediated by dopamine receptors
    Yongjian Xie, Yiyang Chen, Ziwei Wu, Xue Gong, Zhilin Zhang, Shimeng Yang, Dayu Zhang · 2024 · Pesticide Biochemistry and Physiology
61. A novel system to determine activity of individual uridine 5′-diphospho-glucuronosyltransferase (UGT) isoforms: Recombinant UGT-beads
    Ting Wang, Mitchell E. Taub, Tom S. Chan · 2024 · Journal of Biological Chemistry
62. An in silico investigation of the toxicological effects and biological activities of 3-phenoxybenzoic acid and its metabolite products
    Hai Duc Nguyen, Thuy Linh Hoang, Giang Huong Vu · 2024 · Xenobiotica
63. Beyond cytotoxic potency: disposition features required to design ADC payload
    Hao Sun, Larry C. Wienkers, Anthony J. Lee · 2024 · Xenobiotica
64. Proteomic analysis suggests that monoterpenes in lemongrass disrupt Ca 2+ homeostasis in Haemaphysalis longicornis leading to mitochondrial depolarization and cytotoxicity
    Desmond Onyeka Agwunobi, Mengxue Li, Ningmei Wang, Guomin Chang, Xiaojing Zhang, Xiaomin Xue, Zhijun Yu, Hui Wang, Jingze Liu · 2022 · PROTEOMICS
65. Antibiotics in wastewater: perspective of biological treatment processes
    Purusottam Tripathy, Om Prakash, Abhishek Sharma, Deepak Panchal, Sukdeb Pal · 2023 · Elsevier eBooks
66. Humane Enzyme für die organische Synthese
    Margit Winkler, Martina Geier, Steven Paul Hanlon, Bernd Nidetzky, Anton Glieder · 2018 · Angewandte Chemie
67. Tunicate pregnane X receptor (PXR) orthologs: Transcript characterization and natural variation
    Ingrid Richter, Andrew Eric Fidler · 2015 · Marine Genomics
68. Singlet oxygen production and in vitro phototoxicity studies on fenofibrate, mycophenolate mofetil, trifusal, and their active metabolites
    Oscar Molins‐Molina, Roger Bresolí‐Obach, Guillermo García‐Laínez, Inmaculada Andreu, Santi Nonell, Miguel Angel Miranda, M. Consuelo Jiménez · 2017 · Journal of Physical Organic Chemistry
69. In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs
    Risto Olavi Juvonen, Aki T. Heikkinen, Olli K. Kärkkäinen, Rabia Jehangir, Juhani Huuskonen, Johanna Troberg, Hannu Raunio, Olli T. Pentikäinen, Moshe Finel · 2019 · European Journal of Pharmaceutical Sciences
70. CHEMINFORMATICS TOOLS FOR ENABLING METABOLOMICS
    Yannick Djoumbou-Feunang · 2017 · ERA: Education and Research Archive (University of Alberta)
71. Deconjugation enzymes - pitfalls, contamination risks, and practical insights from human biomonitoring of bisphenols, phthalates, and oxidative stress markers
    Ian Zammit, Yuya Cheng, Daniel Bury, Xianyu Wang, Jochen F. Mueller, Holger Martin Koch · 2025 · International Journal of Hygiene and Environmental Health
72. FAME3R: an efficient, practical and reliable open-source tool for predicting phase 1 and phase 2 sites of metabolism
    Roxane Axel Jacob, Leo Gaskin, Thomas Seidel, Ya Chen, Angelica Mazzolari, Johannes Kirchmair · 2026 · Journal of Cheminformatics
73. Role of Personalized Medicine in Clinical Practice: An Overview of Current and Future Perspectives
    Roma Ghai, Ashu Mittal, Deepali Pandey, Md Shamshir Alam, Shikha Kaushik, Pasha Ishtiyaq, Yogita Kaushik, Shardendu Kumar Mishra · 2024 · Biomedical & Pharmacology Journal
74. Carvacrol: A Brief Analysis of Molecular Properties and Their Therapeutic Potential
    Aldo Sena de Oliveira, Aldo Sena de Oliveira · 2020 · American Journal of Medicinal Chemistry
75. Conserved amino acids in the region connecting membrane spanning domain 1 to nucleotide binding domain 1 are essential for expression of the MRP1 (ABCC1) transporter
    Emma E. Smith, Gwenaëlle Conseil, Susan P.C. Cole · 2021 · PLoS ONE
76. Computational Analysis of Chemical Space of Natural Compounds Interacting with Sulfotransferases
    Iglika Lessigiarska, Yunhui Peng, Ivanka Tsakovska, Petko Alov, Nathalie Lagarde, Dessislava Jereva, Bruno O. Villoutreix, Arnaud B. Nicot, Ilza K. Pajeva, Tania Pencheva et al. · 2021 · Molecules
77. Microchip capillary electrophoresis–electrospray ionization mass spectrometry analysis of paracetamol metabolites in human urine: An intriguing case
    Giovanni Lentini, Solomon Habtemariam · 2014 · Journal of Chromatography A
78. MetaTREE, a Novel Database Focused on Metabolic Trees, Predicts an Important Detoxification Mechanism: The Glutathione Conjugation
    Angelica Mazzolari, Luca Sommaruga, Alessandro Pedretti, Giulio Vistoli · 2021 · Molecules
79. An improved dataset of force fields, electronic and physicochemical descriptors of metabolic substrates
    Alessio Macorano, Angelica Mazzolari, Giuliano Malloci, Alessandro Pedretti, Giulio Vistoli, Silvia I. Gervasoni · 2024 · Scientific Data
80. Species-specific toxicological responses in relation to body burden and bioaccumulation pattern of polycyclic aromatic hydrocarbons (PAHs) in a tropical estuarine food web
    Oju Richard Ibor, Andem Bassey, Raymond Odey Ajang, Patrick Ekok, Julius A. Agabi, Beshel S. Beshel, Ama John, Francesco Regoli, Monday M. Onakpa, Augustine Arukwe · 2025 · Journal of Toxicology and Environmental Health
81. Transcriptome Analysis Provides Insights into Hepatic Responses to Trichloroisocyanuric Acid Exposure in Goldfish (Carassius auratus)
    Shun Zhou, Jing Dong, Yongtao Liu, Qiuhong Yang, Ning Xu, Yibin Yang, Xiaohui Ai · 2021 · Animals
82. Preliminary in vitro approach to evaluate the drug-drug interaction potential of EST73502, a dual µ-opioid receptor partial agonist and σ1 receptor antagonist
    Eva Ayet, Sandra Yeste, Raquel F. Reinoso, María José Pretel, Ariadna Balada, Maria Teresa Serafini · 2021 · Xenobiotica
83. Machine Learning Enables Accurate Prediction of Quinone Formation during Drug Metabolism
    Hardeep Sandhu, Prabha Garg · 2023 · Chemical Research in Toxicology
84. Bidirectional Chemical Intelligent Net: A unified deep learning–based framework for predicting chemical reaction
    Xi Xue, Kai Chen, Hanyu Sun, Xiangying Liu, Xue Liu, Shize Li, Jingjie Yan, Yu Peng, Mohammad Suleiman Mubarak, Ahmed Al‐Harrasi et al. · 2025 · Chinese Chemical Letters
85. Metabolism in Drug Development
    Bernard Testa · 2014 · Methods and principles in medicinal chemistry
86. MetaReact: A Reaction-Aware Transformer for End-to-End Prediction of Drug Metabolism
    Yitian Wang, Jingxin Rao, Wei Zhang, Yuqi Shi, Chuanlong Zeng, Rongrong Cui, Yinquan Wang, Jiacheng Xiong, Xutong Li, Mingyue Zheng · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
87. Tissue-Specific Accumulation, Toxicological Effects, and Detoxification Strategies in the Mysid Neomysis awatschensis Exposed to Dissolved Paralytic Shellfish Toxins
    Jiangbing Qiu, Xiaoqing Xu, Guangyao Wu, Xiaoyun Wang, Xue Wang, Jinglin Liu, Aifeng Li · 2025 · Environmental Science & Technology
88. Artificial Intelligence for Drug Delivery
    Xinmin Yu, Xinyun Jiang, Tao Sheng, Phylisse Nichelle Tiong, Jicheng Yu, Feng Zhu, Defang Ouyang, Marı́a José Alonso, Jianqing Gao, Zhen Gu et al. · 2026 · ACS Nano
89. CHEMOPREVENTIVE EFFICACY OF ADHATODA VASICA LEAVES IN 7,12- DIMETHYLBENZ(A)ANTHRACENE INDUCED ORAL CARCINOGENESIS
    Shanmugam Manoharan, Murugaraj Manoj Prabhakar · 2015 · International Journal of Pharma and Bio Sciences
90. The role of drug metabolism in drug discovery and development : case ospemifene
    Jouko Uusitalo · 2015
91. Computational approaches for drug-metabolizing enzymes: Concepts and challenges
    Usman Ali Ashfaq, Farah Shahid, Samman Munir · 2022 · Elsevier eBooks
92. Pharmacochemical Study of Multitarget Amino Acids’ Hybrids: Design, Synthesis, In vitro , and In silico Studies
    Ioannis Fotopoulos, Eleni A. Pontiki, Dimitra Hadjipavlou‐Litina · 2024 · Medicinal Chemistry
93. Novel (±)- trans - β -lactam ureas: Synthesis, in silico and in vitro biological profiling
    Mladenka Jurin, Višnja Stepanić, Krunoslav Bojanić, Denis Vadlja, Darko Kontrec, Tonko Dražić, Marin Roje · 2024 · Acta Pharmaceutica
94. Profiling gene expression dynamics underpinning conventional testing approaches to better inform pre-clinical evaluation of an age appropriate spironolactone formulation
    Craig A. Russell, Majad Hussain, David S. Huen, Ayesha Rahman, Afzal R. Mohammed · 2020 · Pharmaceutical Development and Technology
95. The Why and How of Absorption, Distribution, Metabolism, Excretion, and Toxicity Research
    H. Van De Waterbeemd, Bernard Testa · 2013 · Elsevier eBooks
96. Drug Metabolism Synthetic (Phase II) Reactions
    Alan Talevi, Carolina L. Bellera · 2021 · Springer eBooks
97. Drug Metabolism Functionalization (Phase I) Reactions
    Alan Talevi, Carolina L. Bellera · 2021 · Springer eBooks
98. Drug Metabolism
    Alan Talevi, Carolina L. Bellera · 2022 · Springer eBooks
99. Artificial Intelligence in Drug Development
    Surovi Saikia, Aparna Anandan, Unais Annenkottil, Vishnu Prabhu Athilingam, Partha Pratim Kalita, V. Vijaya Padma · 2025 · Wiley eBooks
100. Drug Metabolism
     Alan Talevi, Carolina L. Bellera · 2024 · Springer eBooks