The DOI matches its Crossref record; 95 of the 98 references it cites were found in a registry or an index.
Myostatin: more than just a regulator of muscle mass
Abstract
The presence of sufficient skeletal muscle mass is of paramount importance for body function and the myostatin cascade is known to inhibit muscle growth in mammals. In addition, myostatin seems to have an important role in the cross-talk between skeletal muscle and adipose tissue and is involved in insulin sensitivity. In this article we highlight the latest developments related to the myostatin system, emphasizing therapeutic implications for wasting diseases and also the involvement of the system in other organs, in addition to skeletal muscle, such as heart or adipose tissue. Moreover, we highlight the possible role of the myostatin system in the cross-talk between skeletal muscle and adipose tissue, an important aspect that deserves consideration in wasting diseases.
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In the citing paper
“However, it is known today that myostatin is also expressed and secreted even in adulthood (Argiles et al., 2012).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Argiles et al., 2012
In the citing paper
“Myostatin was first described to be secreted during development to limit muscle growth 143, but is also known today to be produced in adults 144, and to promote muscle atrophy, in part by inhibiting AKT and mTOR signaling.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [144]
In the citing paper
“Myostatin was first described to be secreted during development to limit muscle growth 143, but is also known today to be produced in adults 144, and to promote muscle atrophy, in part by inhibiting AKT and mTOR signaling.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [144]
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Items 101–124 of 124
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Myostatin Expression in MDS Patients with Wasting Syndrome
Garlemou, K., Alexandrakis, M. G., Karras, G., Kyriakou, D. S., & Kourelis, T. (2022) · Asian Journal of Biological Sciences · doi:10.3923/ajbs.2022.40.48
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Meng, Q., & Zhang, Y. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40423-8.00013-0
Myostatin in the pituitary–muscle axis: Roles in health and disease
Iglesias, P. (2026) · Endocrinología Diabetes y Nutrición (English ed ) · doi:10.1016/j.endinu.2025.501757
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Sánchez, S. S., da Fonseca, G. W. P., & von Haehling, S. (2026) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2026.102114
Kang, S., Yan, W., Yu, Y., Wang, W., Fan, X., Sun, L., Tang, L., & Ta, D. (2026) · Journal of Ultrasound in Medicine · doi:10.1002/jum.70489
Metadata
- Authors
- Argilés, J. M., Orpí, M., Busquets, S., & López-Soriano, F. J.
- Affiliations
- Institut de Biomedicina de la Universitat de Barcelona (ES)
- Universitat de Barcelona (ES)
- Venue
- Drug Discovery Today
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 17
- Issue
- 13-14
- Pages
- 702-709
- ISSN
- 1359-6446 (ISSN-L)
- OpenAlex
- W1975544443
- Cited by
- 125
- References
- 98
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 13 · 2021: 7 · 2020: 8 · 2019: 11 · 2018: 14 · 2017: 13 · 2016: 13 · 2015: 9 · 2014: 10 · 2013: 8
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug Discovery Today (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Keywords
- myostatin, skeletal muscle mass, insulin sensitivity, wasting disease, muscle atrophy, heart, adipose tissue, therapeutic target
- MeSH terms
- Adipose Tissue, Animals, Cachexia, Exercise Therapy, Glucocorticoids, Humans, Insulin Resistance, Organ Size, Muscle, Skeletal, Wasting Syndrome, Myostatin
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