DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans

Concordance of the toxicity of pharmaceuticals in humans and in animals

Olson, H., Betton, G., Robinson, D., Thomas, K., Monro, A., Kolaja, G., Lilly, P., Sanders, J., Sipes, G., Bracken, W., et al. (2000) · Regulatory Toxicology and Pharmacology · doi:10.1006/rtph.2000.1399 · Cited by 2,050

Idiosyncratic drug hepatotoxicity

Kaplowitz, N. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1750 · Cited by 1,054

Timing of new black box warnings and withdrawals for prescription medications

Lasser, K. E. (2002) · JAMA · doi:10.1001/jama.287.17.2215 · Cited by 1,005

Features and outcomes of 899 patients with drug-induced liver injury: the DILIN Prospective Study

Chalasani, N., Bonkovsky, H. L., Fontana, R., Lee, W., Stolz, A., Talwalkar, J., Reddy, K. R., Watkins, P. B., Navarro, V., Barnhart, H., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.03.006 · Cited by 925

Drug-Induced Liver Injury: An Analysis of 461 Incidences Submitted to the Spanish Registry Over a 10-Year Period

ANDRADE, R., LUCENA, M., FERNANDEZ, M., PELAEZ, G., PACHKORIA, K., GARCIARUIZ, E., GARCIAMUNOZ, B., GONZALEZGRANDE, R., PIZARRO, A., & DURAN, J. (2005) · Gastroenterology · doi:10.1016/j.gastro.2005.05.006 · Cited by 856

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

Xu, J. J., Henstock, P. V., Dunn, M. C., Smith, A. R., Chabot, J., & de Graaf, D. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfn109 · Cited by 505

Mitochondrial toxicity of nrti antiviral drugs: an integrated cellular perspective

Lewis, W., Day, B. J., & Copeland, W. C. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1201 · Cited by 496

In vitro models for liver toxicity testing

Soldatow, V. Y., LeCluyse, E. L., Griffith, L. G., & Rusyn, I. (2012) · Toxicology Research · doi:10.1039/c2tx20051a · Cited by 482

FDA-approved drug labeling for the study of drug-induced liver injury

Chen, M., Vijay, V., Shi, Q., Liu, Z., Fang, H., & Tong, W. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2011.05.007 · Cited by 406

Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: Search for signals

Lammert, C. S., Einarsson, S., Saha, C., Niklasson, A., Bjornsson, E. S., & Chalasani, N. (2008) · Hepatology · doi:10.1002/hep.22272 · Cited by 389

PubChem 2023 update

Kim, S., Chen, J., Cheng, T., Gindulyte, A., He, J., He, S., Li, Q., Shoemaker, B. A., Thiessen, P. A., Yu, B., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkac956 · Cited by 3,443

ProTox-II: a webserver for the prediction of toxicity of chemicals

Banerjee, P., Eckert, A. P., Schrey, A. K., & Preißner, R. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky318 · Cited by 3,312

EASL Clinical Practice Guidelines: Drug-induced liver injury

Andrade, R. J., Aithal, G. P., Björnsson, E. S., Kaplowitz, N., Kullak-Ublick, G. A., Larrey, D., & Karlsen, T. H. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.02.014 · Cited by 1,276

Drug-induced liver injury: recent advances in diagnosis and risk assessment

Kullak-Ublick, G. A., Andrade, R. J., Merz, M., End, P., Benesic, A., Gerbes, A. L., & Aithal, G. P. (2017) · Gut · doi:10.1136/gutjnl-2016-313369 · Cited by 438

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

Fontana, R. J., Liou, I., Reuben, A., Suzuki, A., Fiel, M. I., Lee, W., & Navarro, V. (2023) · Hepatology · doi:10.1002/hep.32689 · Cited by 340

DILIrank dataset for QSAR modeling of drug-induced liver injury

Chen, M., Liao, T.-J., Li, D., Ning, B., Hong, H., & Tong, W. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15339-6.00014-x

FDA use of the black box warning: time for reevaluation as a safety tool

Liang, B. A. (2002) · Journal of Clinical Anesthesia · doi:10.1016/s0952-8180(02)00444-0 · Cited by 15

DILIrank 2.0: An updated and expanded database for drug-induced liver injury risk based on FDA labeling and a literature review

Olubamiwa, A. O., Qu, Y., Connor, S., Tong, W., Li, D., & Chen, M. (2025) · Drug Discovery Today · doi:10.1016/j.drudis.2025.104485 · Cited by 9

Drug-induced liver injury severity and toxicity (DILIst): binary classification of 1279 drugs by human hepatotoxicity

Thakkar, S., Li, T., Liu, Z., Wu, L., Roberts, R., & Tong, W. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2019.09.022 · Cited by 140

Drug-Induced Liver Injury (DILI) Classification and Its Application on Human DILI Risk Prediction

Thakkar, S., Chen, M., Hong, H., Liu, Z., Fang, H., & Tong, W. (2018) · Methods in pharmacology and toxicology · doi:10.1007/978-1-4939-7677-5_3 · Cited by 8

The Liver Toxicity Knowledge Base (LKTB) and drug-induced liver injury (DILI) classification for assessment of human liver injury

Thakkar, S., Chen, M., Fang, H., Liu, Z., Roberts, R. A., & Tong, W. (2017) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2018.1383154 · Cited by 62

Modelling of Drug-Induced Liver Injury with Multiple Machine Learning Algorithms

Lesiński, W., Golińska, A. K., & Rudnicki, W. R. (2024) · Communications in computer and information science · doi:10.1007/978-3-031-70259-4_33

Predicting the Risks of Drug-Induced Liver Injury in Humans Utilizing Computational Modeling

Chen, M., Zhu, J., Ashby, K., Wu, L., Liu, Z., Gong, P., Zhang, C., Borlak, J. T., Hong, H., & Tong, W. (2019) · Challenges and advances in computational chemistry and physics · doi:10.1007/978-3-030-16443-0_13 · Cited by 1

i-DILI: A Multi Source Database for Drug Induced Liver Injury Labeling and BenchmarkingPreprint

Shende, S., & Tembhurne, J. V. (2026) · Preprints.org · doi:10.20944/preprints202609.0517.v1

Quantitative Structure-Activity Relationship Models for Predicting Drug-Induced Liver Injury Based on FDA-Approved Drug Labeling Annotation and Using a Large Collection of Drugs

Chen, M., Hong, H., Fang, H., Kelly, R. J., Zhou, G., Borlak, J. T., & Tong, W. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft189 · Cited by 121