The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Physicochemical properties affecting the fate of nanoparticles in pulmonary drug delivery
Abstract
The inhaled delivery of nanomedicines has attracted much attention in the treatment of lung diseases or systemic diseases. However, there is a lack of understanding about their fate upon lung delivery. Thus, the objective of this review is to summarize physicochemical properties affecting the fate of nanoparticles after deposition in the lung. First, physiological structure and characteristics of the lung are described. Thereafter, physicochemical properties that could influence the clearance and translocation of nanoparticles in the lung are discussed, including particle size, surface charge and surface hydrophilicity. It is believed that, with a better understanding of the fate of nanoparticles in the lung, it will broaden their application in inhalation for a better therapeutic effect in the future.
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Cites
Controlled pulmonary drug and gene delivery using polymeric nano-carriers
Beck-Broichsitter, M., Merkel, O. M., & Kissel, T. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.12.004 · Cited by 200
Enhanced rifampicin delivery to alveolar macrophages by solid lipid nanoparticles
Chuan, J., Li, Y., Yang, L., Sun, X., Zhang, Q., Gong, T., & Zhang, Z. (2013) · Journal of Nanoparticle Research · doi:10.1007/s11051-013-1634-1 · Cited by 107
Zhong, Q., Bielski, E. R., Rodrigues, L. S., Brown, M. R., Reineke, J. J., & da Rocha, S. R. P. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b00126 · Cited by 88
Cited by
Polymeric Nanoparticles for Drug Delivery
Beach, M. A., Nayanathara, U., Gao, Y., Zhang, C., Xiong, Y., Wang, Y., & Such, G. K. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00705 · Cited by 1,155
Xu, M., Qi, Y., Liu, G., Song, Y., Jiang, X., & Du, B. (2023) · ACS Nano · doi:10.1021/acsnano.3c05853 · Cited by 632
The in vivo fate of polymeric micelles
Cai, Y., Qi, J., Lu, Y., He, H., & Wu, W. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114463 · Cited by 154
Zhu, J., Guo, M., Cui, Y., Meng, Y., Ding, J., Zeng, W., & Zhou, W. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c23069 · Cited by 46
Metadata
- Authors
- Liu, Q., Guan, J., Qin, L., Zhang, X., & Mao, S.
- Venue
- Drug Discovery Today
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 25
- Issue
- 1
- Pages
- 150-159
- ISSN
- 1359-6446 (ISSN-L)
- OpenAlex
- W2979916718
- Cited by
- 229
- References
- 3
- FWCI
- 14.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liu, Q., Guan, J., Qin, L., Zhang, X., & Mao, S. (2020). Physicochemical properties affecting the fate of nanoparticles in pulmonary drug delivery. Drug Discovery Today. https://doi.org/10.1016/j.drudis.2019.09.023
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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