Severity of childhood trauma is predictive of cocaine relapse outcomes in women but not men
Open accessAbstract
We prospectively examined the gender-specific effects of childhood trauma on cocaine relapse outcomes in an inpatient sample of treatment engaged cocaine dependent adults. Cocaine dependent men (n=70) and women (n=54) participating in inpatient treatment for cocaine dependence were assessed on severity of childhood trauma and followed for 90 days after discharge from treatment. Greater severity of childhood emotional abuse was associated with an increased risk of relapse in women. Severity of emotional abuse, sexual abuse, and overall childhood trauma was associated with the number of days cocaine was used during follow-up in women, as was the association of severity of physical abuse and overall childhood trauma with the average amount of cocaine used per occasion. No associations between childhood trauma and cocaine relapse outcomes were found in men. These findings demonstrate that childhood trauma increases the likelihood of cocaine relapse and drug use escalation after initial relapse in women but not in men. Comprehensive assessments of childhood trauma and specialized treatments that address trauma-related pathophysiology could be of benefit in improving cocaine treatment outcomes in women.
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Among adults seeking treatment for cocaine dependence, victimization types and overall trauma severity predicted relapse for women but not for men.
“Finally, a study of adults presenting for cocaine dependence found that the types of victimization experienced and overall trauma severity were predictive of relapse for women, but not men (Hyman et al., 2008).”
From Influences of victimization and comorbid conditions on latency to illicit drug use among adolescents and young adults (2020) · cites this paper as Hyman et al., 2008
Victimization effects on SUD outcomes may vary by gender and may be stronger for females, but the evidence is mixed.
“Prior work notes that the effects of victimization on SUD outcomes may differ by gender, and may be more pronounced for females, although evidence is mixed.”
From Influences of victimization and comorbid conditions on latency to illicit drug use among adolescents and young adults (2020) · cites this paper as Hyman et al., 2008
Victimization is a stronger predictor of SUD outcomes for females than males.
“and that victimization is a stronger predictor of SUD outcomes for females than males (Hyman et al., 2008; Moran et al., 2004; Shane et al., 2006).”
From Influences of victimization and comorbid conditions on latency to illicit drug use among adolescents and young adults (2020) · cites this paper as Hyman et al., 2008
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References 63 · Cited by 166
Research works printed but not linked: 4
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- Authors
- Hyman, S. M., Paliwal, P., Chaplin, T. M., Mazure, C. M., Rounsaville, B. J., & Sinha, R.
- Affiliations
- Yale University (US)
- Corresponding author
- Hyman, Scott M.
- Venue
- Drug and Alcohol Dependence
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 92
- Issue
- 1-3
- Pages
- 208-216
- ISSN
- 0376-8716 (ISSN-L)
- PMC
- PMC2233653
- OpenAlex
- W2077231388
- Cited by
- 166
- References
- 63
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 7 · 2023: 18 · 2022: 11 · 2021: 15 · 2020: 10 · 2019: 10 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 9 · 2014: 10 · 2013: 14 · 2012: 9
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Drug and Alcohol Dependence (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Yale University
- National Institute on Drug Abuse (K02 DA17232, P50DA016556, K02DA017232, R01-DA11077, R01DA011077, P50-DA16556)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Keywords
- childhood trauma, cocaine relapse, cocaine dependence, gender differences, emotional abuse, sexual abuse, physical abuse, inpatient care, women
- MeSH terms
- Adult, Child, Child Abuse, Sexual, Data Interpretation, Statistical, Female, Follow-Up Studies, Humans, Inpatients, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Psychiatric Status Rating Scales, Surveys and Questionnaires, Recurrence, Sex Characteristics, Socioeconomic Factors, Substance Abuse Treatment Centers, Cocaine-Related Disorders, Adult Survivors of Child Abuse
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