The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Pathways between nonmedical opioid use/dependence and psychiatric disorders: Results from the National Epidemiologic Survey on Alcohol and Related Conditions
Open accessAbstract
Background While nonmedical use of opioids and psychiatric disorders are prevalent in the population, little is known about the temporal ordering between nonmedical opioid use and dependence and psychiatric disorders. Method Data were gathered in a face-to-face survey of the United States conducted in the 2001-2002 (NESARC wave 1). Participants were household and group quarters residents aged 18 years and older (n=43,093). Cox proportional hazards models with time-dependent covariates were used to investigate potential pathways between lifetime nonmedical opioid use/dependence and psychiatric disorders. Results Preexisting psychiatric disorders (mood disorders, major depressive disorder, bipolar I disorder, anxiety disorders, panic and generalized anxiety disorders) were associated with an increased risk of nonmedical opioid use, with hazard ratios ranging from 2.2[95% CI=1.6-3.1] (any anxiety disorder) to 3.1[95% CI= 2.4-2.4] (bipolar I disorder). Preexisting nonmedical opioid use was associated with an increased risk of onset of psychiatric disorders, with hazard ratios ranging from 2.8[95% CI=:2.2-3.6] (generalized anxiety disorder) to 3.6[95% CI=2.6-4.9] (bipolar I disorder), adjusted for demographics and other illegal drug use. Nonmedical use of opioids led to the development of dependence more often among individuals with preexisting psychiatric disorders, hazard ratios were particularly strong for generalized anxiety disorder (HR=10.8, 95% CI= 4.9-23.7) and bipolar I disorder (HR=9.7, 95% CI=5.4-17.3). Preexisting opioid dependence resulting from nonmedical opioid use was associated with an increased risk of onset of psychiatric disorders, with hazard ratios ranging from 4.9[95% CI=3.0-7.9] (mood disorders) to 8.5[95% CI=4.5-16.0] (panic disorder), adjusted for demographics and alcohol and/or other illegal drug dependence. Conclusions Our findings support a general vulnerability to nonmedical opioid use and major psychopathologies, as well as evidence for a ‘self-medication’ model for dependence resulting from nonmedical opioid use with bipolar disorder and generalized anxiety disorder.
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Cites
The Self-Medication Hypothesis of Substance Use Disorders: A Reconsideration and Recent Applications
Khantzian, E. J. (1997) · Harvard Review of Psychiatry · doi:10.3109/10673229709030550 · Cited by 3,242 · cited 2×
“…individuals start using a drug and become dependent on it to alleviate distress and psychiatric symptoms; the second, that there is correspondence between the neurobiological effects of the drug used and the specific symptomotology of the psychiatric disorder (Khantzian, 1997; Khantzian, 2003).”
BackgroundHasin, D. S., Stinson, F. S., Ogburn, E., & Grant, B. F. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.7.830 · Cited by 2,908
Kendler, K. S., Prescott, C. A., Myers, J., & Neale, M. C. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.9.929 · Cited by 1,868
Hasin, D. S., Goodwin, R. D., Stinson, F. S., & Grant, B. F. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.10.1097 · Cited by 1,645
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Comorbidity between DSM-IV alcohol use disorders and major depression: results of a national survey
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II. Reinforcement Theory and the Dynamics of Alcoholism
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The epidemiology of dual diagnosis
Kessler, R. C. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.06.034 · Cited by 588 · cited 2×
“These studies fit into a more broad well-documented area f research indicating that psychiatric disorders occur more freuently in drug using and dependent individuals than among on-drug using individuals (Kessler et al., 2003; Kessler, 2004; andel et al., 1997; Regier et al., 1990; Rounsaville et al., 1991; rant and H…”
BackgroundRosenblum, A. (2003) · JAMA · doi:10.1001/jama.289.18.2370 · Cited by 523
Hasin, D., Carpenter, K. M., McCloud, S., Smith, M., & Grant, B. F. (1997) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(97)01332-x · Cited by 369
Cited by
Keyes, K. M., Cerdá, M., Brady, J. E., Havens, J. R., & Galea, S. (2014) · American Journal of Public Health · doi:10.2105/ajph.2013.301709 · Cited by 580
Self-citationHasin, D. S., & Grant, B. F. (2015) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-015-1088-0 · Cited by 452
Turner, S., Mota, N., Bolton, J., & Sareen, J. (2018) · Depression and Anxiety · doi:10.1002/da.22771 · Cited by 432
Long-Term Course of Opioid Addiction
Hser, Y.-I., Evans, E., Grella, C., Ling, W., & Anglin, D. (2015) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000052 · Cited by 299
Martins, S. S., Fenton, M. C., Keyes, K. M., Blanco, C., Zhu, H., & Storr, C. L. (2012) · Psychological Medicine · doi:10.1017/s0033291711002145 · Cited by 283
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Metadata
- Authors
- Martins, S. S., Keyes, K. M., Storr, C. L., Zhu, H., & Chilcoat, H. D.
- Venue
- Drug and Alcohol Dependence
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 103
- Issue
- 1-2
- Pages
- 16-24
- ISSN
- 0376-8716 (ISSN-L)
- OpenAlex
- W2131816754
- Cited by
- 182
- References
- 12
- FWCI
- 8.03
- Type
- journal article
- Language
- en
- Open access
- green
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