Serum chemerin levels in Polycystic Ovary Syndrome after metformin therapy
Abstract
Objectives The aim of this study was to study the effects of metformin therapy on serum chemerin levels in some phenotypes of polycystic ovarian syndrome cases, and to correlate chemerin levels with insulin resistance parameters and with hormonal profile.Material and methods This study was carried on 100 polycystic ovary cases and 70 control women. These cases were further subdivided into obese and normal weight cases. Fasting serum chemerin was measured by Enzyme-Linked Immunosorbent Assay method. Data were analyzed using SPSS for Windows 7.Results Before metformin therapy, the serum chemerin were significantly increased in PCOS cases as compared with the control cases. Also, a significantly higher chemerin levels were found in obese polycystic ovarian syndrome cases as compared with normal weight cases with polycystic ovarian syndrome. The serum chemerin levels were significantly positively correlated with glucose levels, insulin levels, and HOMA-IR in polycystic ovarian syndrome cases. After three months of metformin therapy, the serum chemerin, insulin, and HOMA-IR concentrations were significantly decreased in polycystic ovarian syndrome cases as compared with the levels before therapy.Conclusion The serum chemerin levels were significantly higher in cases of PCOS cases as compared with the controls. Metformin therapy resulted in a significant decrease in chemerin levels in polycystic ovarian syndrome cases. The analysis of Receiver Operation Characteristic curves of serum chemerin suggested that serum chemerin levels may be of value to evaluate the polycystic ovarian syndrome cases under various methods of treatments.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Metformin might alleviate symptoms and treat PCOS by correcting abnormal levels of certain adipokines, such as resistin, visfatin, irisin, and chemerin.
“Metformin might alleviate the symptoms and treat PCOS by correcting the abnormal levels of certain adipokines, such as resistin, visfatin, irisin, and chemerin levels (18, 52–54).”
From Circulating Adipokine Levels in Nonobese Women with Polycystic Ovary Syndrome and in Nonobese Control Women: A Systematic Review and Meta-Analysis (2021) · cites this paper as [18]
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Adipose Tissue as an Endocrine Organ
Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522 · see citing works
Chemerin Is a Novel Adipokine Associated with Obesity and Metabolic Syndrome
Bozaoglu, K., Bolton, K. A., McMillan, J. S., Zimmet, P., Jowett, J. B. M., Collier, G. R., Walder, K. R., & Segal, D. (2007) · Endocrinology · doi:10.1210/en.2007-0175 · Cited by 859 · see citing works
Fleming, R., Hopkinson, Z. E., Wallace, A. M., Greer, I. A., & Sattar, N. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.2.8261 · Cited by 366 · see citing works
Kaur, J., Adya, R., Tan, B. K., Chen, J., & Randeva, H. S. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.12.150 · Cited by 349 · see citing works
Chemerin Exacerbates Glucose Intolerance in Mouse Models of Obesity and Diabetes
Ernst, M. C., Issa, M. E., Goralski, K. B., & Sinal, C. J. (2010) · Endocrinology · doi:10.1210/en.2009-1098 · Cited by 260 · see citing works
Chemerin Is Associated with Metabolic Syndrome Phenotypes in a Mexican-American Population
Bozaoglu, K., Segal, D., Shields, K. A., Cummings, N., Curran, J. E., Comuzzie, A. G., Mahaney, M. C., Rainwater, D. L., VandeBerg, J. L., MacCluer, J. W., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1833 · Cited by 255 · see citing works
Chemerin, a Novel Adipokine in the Regulation of Angiogenesis
Bozaoglu, K., Curran, J. E., Stocker, C. J., Zaibi, M. S., Segal, D., Konstantopoulos, N., Morrison, S., Carless, M. A., Dyer, T. D., Cole, S. A., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0042 · Cited by 226 · see citing works
Insulin and Metformin Regulate Circulating and Adipose Tissue Chemerin
Tan, B. K., Chen, J., Syed, F., Adya, R., Kaur, J., Heutling, D., Lewandowski, K. C., O’Hare, J. P., Lehnert, H., & Randeva, H. S. (2009) · Diabetes · doi:10.2337/db08-1528 · Cited by 195 · see citing works
Jialal, I., Devaraj, S., Kaur, H., ADAMS-HUET, B. A., & Bremer, A. A. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3673 · Cited by 155 · see citing works
Diamanti‐Kandarakis, E. (2006) · Endocrine · doi:10.1385/endo:30:1:13 · Cited by 136 · see citing works
Muruganandan, S., Parlee, S. D., Rourke, J. L., Ernst, M. C., Goralski, K. B., & Sinal, C. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.220491 · Cited by 125 · see citing works
Wang, Q., Kim, J. Y., Xue, K., Liu, J., Leader, A., & Tsang, B. K. (2012) · Endocrinology · doi:10.1210/en.2012-1424 · Cited by 118 · see citing works
Haas, D. A., Carr, B. R., & Attia, G. R. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(02)04800-8 · Cited by 77 · see citing works
Obesity, Adipokines and Metabolic Syndrome in Polycystic Ovary Syndrome
Carmina, E. (2012) · Frontiers of hormone research · doi:10.1159/000341840 · Cited by 64 · see citing works
Omentin and chemerin and their association with obesity in women with polycystic ovary syndrome
Güzel, E. Ç., Celik, C., Abalı, R., Küçükyalçın, V., Celik, E., GÜZEL, M., & Yılmaz, M. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2014.888412 · Cited by 58 · see citing works
Chemerin as a marker of body fat and insulin resistance in women with polycystic ovary syndrome
Kort, D. H., Kostolias, A., Sullivan, C., et al. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2014.968547 · Cited by 48 · see citing works
Assessment of serum chemerin, vaspin and omentin-1 levels in patients with polycystic ovary syndrome
Güvenç, Y., Var, A., Göker, A., & Kuşçu, N. K. (2016) · Journal of International Medical Research · doi:10.1177/0300060516645421 · Cited by 48 · see citing works
Akbarzadeh, S., Ghasemi, S., Kalantarhormozi, M., et al. (2012) · Gynecological Endocrinology · doi:10.3109/09513590.2011.650747 · Cited by 35 · see citing works
Metformin Therapy for the Management of Infertility in Women with Polycystic Ovary Syndrome
(2017) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.14764 · Cited by 23 · see citing works
Elevated serum chemerin in Chinese women with hyperandrogenic PCOS
Wang, L., Zhong, Y., Ding, Y., Shi, X., Huang, J. V., & Zhu, F. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2014.928687 · Cited by 19 · see citing works
Ademoglu, E. N., Berberoğlu, Z., Çarlıoğlu, A., et al. (2014) · PubMed · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Lin, K., Sun, X., Wang, X., Wang, H., & Chen, X. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.537809 · Cited by 81 · see citing works
- Authors
- Foda, A. A., Foda, E. A., El-Negeri, M. A., & El-Said, Z. H.
- Affiliations
- Mansoura University (EG)
- Corresponding author
- Foda, Ashraf A.
- ORCID
- El-Said, Zeinab H.
- Venue
- Diabetes & Metabolic Syndrome: Clinical Research & Reviews
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 13
- Issue
- 2
- Pages
- 1309-1315
- ISSN
- 1871-4021 (ISSN-L)
- OpenAlex
- W2912187033
- Cited by
- 27
- References
- 22
- Citations by year
- 2026: 2 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 11 · 2020: 4
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes & Metabolic Syndrome Clinical Research & Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- chemerin, polycystic ovary syndrome, insulin resistance, HOMA-IR, obesity, serum biomarkers, glucose concentration, insulin levels, diagnostic biomarkers
- MeSH terms
- Adult, Cross-Sectional Studies, Female, Follow-Up Studies, Humans, Hypoglycemic Agents, Metformin, Polycystic Ovary Syndrome, Prognosis, Biomarkers, Case-Control Studies, Chemokines, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
