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Hypothermia associated with clobazam use in adult epilepsy
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“Another important consideration is that patients with severe CP often have compounding risk factors, including decreased muscle mass, impaired shivering response, limited voluntary control of clothing/environment, PEG dependence and malnutrition, reducing metabolic heat production, and chronic antiepileptic therapy modulating CNS neurotransmitters involved in temperature regulation [7-10].”
From Recurrent Severe Hypothermia as a Manifestation of Central Thermoregulatory Dysfunction in a Patient With Cerebral Palsy and Shaken Baby Syndrome (2026) · cites this paper as [9]
In the citing paper
“Another important consideration is that patients with severe CP often have compounding risk factors, including decreased muscle mass, impaired shivering response, limited voluntary control of clothing/environment, PEG dependence and malnutrition, reducing metabolic heat production, and chronic antiepileptic therapy modulating CNS neurotransmitters involved in temperature regulation [7-10].”
From Recurrent Severe Hypothermia as a Manifestation of Central Thermoregulatory Dysfunction in a Patient With Cerebral Palsy and Shaken Baby Syndrome (2026) · cites this paper as [9]
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Research works printed but not linked: 6
- Gauthier, 2015, Clobazam: a safe, efficacious, and newly rediscovered therapeutic for epilepsy, CNS Neurosci Ther, 21, 543, 10.1111/cns.12399 · DOI
- Sankar, 2012, GABA(A) receptor physiology and its relationship to the mechanism of action of the 1,5-benzodiazepine clobazam, CNS Drugs, 26, 229, 10.2165/11599020-000000000-00000 · DOI
- Ng, 2007, Clobazam, Neurotherapeutics, 4, 138, 10.1016/j.nurt.2006.11.002 · DOI
- DiFazio, 2014, Profound hypothermia secondary to clobazam use in epilepsy: a novel association, Neurosci Med, 05, 15, 10.4236/nm.2014.51003 · DOI
- Mallet, 2002, Pathophysiology of accidental hypothermia, Q J Med, 95, 775, 10.1093/qjmed/95.12.775 · DOI · Paper page
- Dimitrov, 2011, Regulation of hypothalamic signaling by tuberoinfundibular peptide of 39 residues is critical for the response to cold: a novel peptidergic mechanism of thermoregulation, J Neurosci, 31, 18166, 10.1523/JNEUROSCI.2619-11.2011 · DOI
Cited by
Allnutt, B., Petrasko, P., & Jacob, R. (2026) · Cureus · doi:10.7759/cureus.102330
Metadata
- Authors
- Gauthier, A. C., Quraishi, I. H., & Mattson, R. H.
- Venue
- Epilepsy & Behavior Case Reports
- Publisher
- Elsevier BV
- Published
- 2016
- Volume
- 5
- Pages
- 17-18
- ISSN
- 2213-3232
- Cited by
- 6
- References
- 0
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 13 d)
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
