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Genetic Factors of the Disease Course after Sepsis: A Genome-Wide Study for 28Day Mortality

Scherag, André, Schöneweck, Franziska, Kesselmeier, Miriam, Taudien, Stefan, Platzer, Matthias, Felder, Marius, Sponholz, Christoph, Rautanen, Anna, Hill, Adrian V.S., Hinds, Charles J., Hossain, Hamid, Suttorp, Norbert, Kurzai, Oliver, Slevogt, Hortense, Giamarellos-Bourboulis, Evangelos J., Armaganidis, Apostolos, Trips, Evelyn, Scholz, Markus, Brunkhorst, Frank M.·2016·EBioMedicine
DOI 10.1016/j.ebiom.2016.08.043PMC PMC5078589
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Fig. 1 Discovery GWAS: a) Manhattan plot for the analysis of 28 day mortality in patients with treated sepsis (additive genetic model). The blue line represents the significance level for a suggestive association signal (i.e. p ≤ 1 × 10− 5) and the red line is the level for a genome-wide association signal (i.e. p ≤ 5 × 10− 8). b) Quantile–quantile (Q–Q) plot of all the GWAS p-values (λ = 1.0079) from the analysis of 28 day mortality in patients with treated sepsis (additive genetic model).
Fig. 1 Discovery GWAS: a) Manhattan plot for the analysis of 28 day mortality in patients with treated sepsis (additive genetic model). The blue line represents the significance level for a suggestive association signal (i.e. p ≤ 1 × 10− 5) and the red line is the level for a genome-wide association signal (i.e. p ≤ 5 × 10− 8). b) Quantile–quantile (Q–Q) plot of all the GWAS p-values (λ = 1.0079) from the analysis of 28 day mortality in patients with treated sepsis (additive genetic model).CC BY-NC-ND · PubMed Central
Fig. 2 Regional association plot for a) the chromosome 9q21.2 locus (centered around the lead SNP rs117983287) and b) the chromosome 16 locus (centered around the lead SNP rs2641697) in the analysis of 28 day mortality in patients with treated severe sepsis/septic shock (additive genetic model). Colors indicate the correlation (r2 in 1000 Genomes data for Utah residents with northern or western European ancestry (CEU); phase 1, version 3) with the alleles of rs117983287/rs2641697.
Fig. 2 Regional association plot for a) the chromosome 9q21.2 locus (centered around the lead SNP rs117983287) and b) the chromosome 16 locus (centered around the lead SNP rs2641697) in the analysis of 28 day mortality in patients with treated severe sepsis/septic shock (additive genetic model). Colors indicate the correlation (r2 in 1000 Genomes data for Utah residents with northern or western European ancestry (CEU); phase 1, version 3) with the alleles of rs117983287/rs2641697.CC BY-NC-ND · PubMed Central

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Metadata

Authors
Scherag, A., Schöneweck, F., Kesselmeier, M., Taudien, S., Platzer, M., Felder, M., Sponholz, C., Rautanen, A., Hill, A. V. S., Hinds, C. J., Hossain, H., Suttorp, N., Kurzai, O., Slevogt, H., Giamarellos-Bourboulis, E. J., Armaganidis, A., Trips, E., Scholz, M., & Brunkhorst, F. M.
ORCID
Venue
EBioMedicine
Publisher
Elsevier BV
Published
2016-10
Volume
12
Pages
239-246
ISSN
2352-3964
DOI
10.1016/j.ebiom.2016.08.043
PMC
PMC5078589
Cited by
62
References
4
Language
en
Licence
Funders
  • Bayer HealthCare
  • European Commission
  • Thüringer Ministerium für Bildung, Wissenschaft und Kultur (PE 108-2)
  • Bundesministerium für Bildung und Forschung (01KI07113, 01KI07111, 01KI07110, 01KI1010D, 01KI07114, 01KI1010I, 01 KI 0106, 01 EO 1502, 01 EO 1002)
  • Center for Sepsis Control and Care
  • Novo Nordisk
  • National and Kapodistrian University of Athens

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CoChat. (2026). Citation check: Genetic Factors of the Disease Course after Sepsis: A Genome-Wide Study for 28Day Mortality. https://app.cochat.ai/papers/10.1016/j.ebiom.2016.08.043
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Scherag, A., Schöneweck, F., Kesselmeier, M., Taudien, S., Platzer, M., Felder, M., Sponholz, C., Rautanen, A., Hill, A. V. S., Hinds, C. J., Hossain, H., Suttorp, N., Kurzai, O., Slevogt, H., Giamarellos-Bourboulis, E. J., Armaganidis, A., Trips, E., Scholz, M., & Brunkhorst, F. M. (2016). Genetic Factors of the Disease Course after Sepsis: A Genome-Wide Study for 28Day Mortality. EBioMedicine. https://doi.org/10.1016/j.ebiom.2016.08.043