The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.
Lactate in the tumour microenvironment: From immune modulation to therapy
Open accessAbstract
Disordered metabolic states, which are characterised by hypoxia and elevated levels of metabolites, particularly lactate, contribute to the immunosuppression in the tumour microenvironment (TME). Excessive lactate secreted by metabolism-reprogrammed cancer cells regulates immune responses via causing extracellular acidification, acting as an energy source by shuttling between different cell populations, and inhibiting the mechanistic (previously 'mammalian') target of rapamycin (mTOR) pathway in immune cells. This review focuses on recent advances in the regulation of immune responses by lactate, as well as therapeutic strategies targeting lactate anabolism and transport in the TME, such as those involving glycolytic enzymes and monocarboxylate transporter inhibitors. Considering the multifaceted roles of lactate in cancer metabolism, a comprehensive understanding of how lactate and lactate-targeting therapies regulate immune responses in the TME will provide insights into the complex relationships between metabolism and antitumour immunity.
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Cites
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BackgroundMetabolic regulation of gene expression by histone lactylation
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“Cancer cells with aberrant metabolism consume large amounts of oxygen and nutrients, resulting in hypoxia, nutritional deficiency, and elevated levels of metabolic by-products in the tumour microenvironment (TME) [1].”
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LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells
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BackgroundGlucose feeds the TCA cycle via circulating lactate
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Cited by
Tumor hypoxia: From basic knowledge to therapeutic implications
Liao, C., Liu, X., Zhang, C., & Zhang, Q. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.12.011 · Cited by 223
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Repurposing drugs targeting metabolic diseases for cancer therapeutics
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Shi, X., Hu, L., Huang, Y., Zhang, M.-F., Ying, X., Yuan, X., Wen, N., Lu, J., Zou, H., Tan, X., et al. (2026) · Journal of Advanced Research · doi:10.1016/j.jare.2025.09.014 · Cited by 6
Metadata
- Authors
- Wang, Z.-H., Peng, W.-B., Zhang, P., Yang, X.-P., & Zhou, Q.
- Venue
- EBioMedicine
- Publisher
- Elsevier BV
- Published
- 2021-11
- Volume
- 73
- Pages
- 103627
- ISSN
- 2352-3964 (ISSN-L)
- OpenAlex
- W3207384678
- Cited by
- 528
- References
- 126
- FWCI
- 19.96
- Type
- journal article
- Language
- en
- Open access
- gold
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