Cited by 174Pituitary Gland Disorders and TreatmentsDiabetes, Cardiovascular Risks, and LipoproteinsAdrenal and Paraganglionic Tumors

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The Metabolic Syndrome and Cardiovascular Risk in Cushing's Syndrome

Pivonello, Rosario, Faggiano, Antongiulio, Lombardi, Gaetano, Colao, Annamaria·2005·Endocrinology and Metabolism Clinics of North America

DOI 10.1016/j.ecl.2005.01.010

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Abstract

Cushing's syndrome (CS) is characterized by a series of systemic complications that increase cardiovascular risk and cause severe atherosclerotic damage that develops in parallel with an acquired metabolic syndrome. Short-term remission from hypercortisolism improves metabolic and vascular damages, but long-term remission from CS seems to be associated with similar or worse metabolic and vascular damage, probably because of persistent abdominal obesity or insulin resistance years after normalization of cortisol secretion. Study results suggest that an increased cardiovascular risk also may persist in patients who undergo treatment with exogenous glucocorticoids after therapy withdrawal. Considering the many patients subjected to corticosteroid treatment, this could be of great clinical relevance and should be investigated thoroughly.

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Maroufi, S. P., Maroufi, S. P., Sabahi, M., Borghei-Razavi, H., & Esteghamati, A. (2026) · Neurosurgical Review · doi:10.1007/s10143-026-04407-6
BindingDB Entry 50026714: Blockade of glucocorticoid excess at the tissue level: inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 as a therapy for type 2 diabetes.
BindingDB (2010) · UC San Diego · doi:10.7270/q25x28rd
Pituitary Tumors, ACTH-Secreting
Putignano, P., Giraldi, F. P., & Cavagnini, F. (2004) · Elsevier eBooks · doi:10.1016/b0-12-475570-4/00013-5

Authors: Pivonello, R., Faggiano, A., Lombardi, G., & Colao, A.
Affiliations: Federico II University Hospital (IT)
Corresponding author: Pivonello, Rosario
ORCID: Pivonello, Rosario
Faggiano, Antongiulio
Colao, Annamaria
Venue: Endocrinology and Metabolism Clinics of North America
Publisher: Elsevier BV
Published: 2005-06
Volume: 34
Issue: 2
Pages: 327-339
ISSN: 0889-8529 (ISSN-L)
DOI: 10.1016/j.ecl.2005.01.010
OpenAlex: W1978784950
Cited by: 173
References: 51
Citations by year: 2026: 5 · 2025: 5 · 2024: 8 · 2023: 7 · 2022: 4 · 2021: 2 · 2020: 7 · 2019: 11 · 2018: 8 · 2017: 6 · 2016: 8 · 2015: 9 · 2014: 10 · 2013: 16 · 2012: 14
FWCI: 0.87
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Endocrinology and Metabolism Clinics of North America (publishedVersion)
PubMed (publishedVersion)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
Keywords: Cushing's syndrome, metabolic syndrome, cardiovascular risk, hypercortisolism, atherosclerosis, abdominal obesity, insulin resistance, glucocorticoid therapy, remission, vascular injury
MeSH terms: Cardiovascular Diseases, Humans, Risk Factors, Metabolic Syndrome, Pituitary ACTH Hypersecretion

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The Metabolic Syndrome and Cardiovascular Risk in Cushing's Syndrome

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