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The Metabolic Syndrome and Cardiovascular Risk in Cushing's Syndrome
Abstract
Cushing's syndrome (CS) is characterized by a series of systemic complications that increase cardiovascular risk and cause severe atherosclerotic damage that develops in parallel with an acquired metabolic syndrome. Short-term remission from hypercortisolism improves metabolic and vascular damages, but long-term remission from CS seems to be associated with similar or worse metabolic and vascular damage, probably because of persistent abdominal obesity or insulin resistance years after normalization of cortisol secretion. Study results suggest that an increased cardiovascular risk also may persist in patients who undergo treatment with exogenous glucocorticoids after therapy withdrawal. Considering the many patients subjected to corticosteroid treatment, this could be of great clinical relevance and should be investigated thoroughly.
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“Surgical remission does not eliminate the risk of complications from systemic comorbidities completely (12, 13).”
From Approach to the Patient: Diagnosis of Cushing Syndrome (2022) · cites this paper as [13]
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Metadata
- Authors
- Pivonello, R., Faggiano, A., Lombardi, G., & Colao, A.
- Affiliations
- Federico II University Hospital (IT)
- Corresponding author
- Pivonello, Rosario
- Venue
- Endocrinology and Metabolism Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2005-06
- Volume
- 34
- Issue
- 2
- Pages
- 327-339
- ISSN
- 0889-8529 (ISSN-L)
- OpenAlex
- W1978784950
- Cited by
- 173
- References
- 51
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 8 · 2023: 7 · 2022: 4 · 2021: 2 · 2020: 7 · 2019: 11 · 2018: 8 · 2017: 6 · 2016: 8 · 2015: 9 · 2014: 10 · 2013: 16 · 2012: 14
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology and Metabolism Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Keywords
- Cushing's syndrome, metabolic syndrome, cardiovascular risk, hypercortisolism, atherosclerosis, abdominal obesity, insulin resistance, glucocorticoid therapy, remission, vascular injury
- MeSH terms
- Cardiovascular Diseases, Humans, Risk Factors, Metabolic Syndrome, Pituitary ACTH Hypersecretion
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