The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
An Integrated View of Insulin Resistance and Endothelial Dysfunction
Open accessAbstract
Synopsis Endothelial dysfunction and insulin resistance are frequently co-morbid states. Vasodilator actions of insulin are mediated by phosphatidylinositol 3-kinase (PI3K)-dependent signaling pathways that stimulate production of nitric oxide from vascular endothelium. This helps to couple metabolic and hemodynamic homeostasis under healthy conditions. In pathological states, shared causal factors including glucotoxicity, lipotoxicity, and inflammation selectively impair PI3K-dependent insulin signaling pathways that contribute to reciprocal relationships between insulin resistance and endothelial dysfunction. We discuss implications of pathway-selective insulin resistance in vascular endothelium, interactions between endothelial dysfunction and insulin resistance, and therapeutic interventions that may simultaneously improve both metabolic and cardiovascular physiology in insulin-resistant conditions.
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Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Poirier, P., Giles, T. D., Bray, G. A., Hong, Y., Stern, J. S., Pi-Sunyer, F. X., & Eckel, R. H. (2006) · Circulation · doi:10.1161/circulationaha.106.171016 · Cited by 3,165
Mechanisms linking obesity with cardiovascular disease
Van Gaal, L. F., Mertens, I. L., & De Block, C. E. (2006) · Nature · doi:10.1038/nature05487 · Cited by 2,814
Steinberg, H. O., Chaker, H., Leaming, R., Johnson, A., Brechtel, G., & Baron, A. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118709 · Cited by 1,687
Kim, J.-A., Montagnani, M., Koh, K. K., & Quon, M. J. (2006) · Circulation · doi:10.1161/circulationaha.105.563213 · Cited by 1,652
Cusi, K., Maezono, K., Osman, A., Pendergrass, M., Patti, M. E., Pratipanawatr, T., DeFronzo, R. A., Kahn, C. R., & Mandarino, L. J. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7535 · Cited by 1,139
Du, X. L., Edelstein, D., Dimmeler, S., Ju, Q., Sui, C., & Brownlee, M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11235 · Cited by 907
Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans
Civitarese, A. E., Carling, S., Heilbronn, L. K., Hulver, M. H., Ukropcova, B., Deutsch, W. A., Smith, S. R., & Ravussin, E. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040076 · Cited by 790
Zeng, G., & Quon, M. J. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118871 · Cited by 726
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Cited by
Guo, S. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0327 · Cited by 623
Endothelial Dysfunction as a Target for Prevention of Cardiovascular Disease
Versari, D., Daghini, E., Virdis, A., Ghiadoni, L., & Taddei, S. (2009) · Diabetes Care · doi:10.2337/dc09-s330 · Cited by 516
The impact of insulin resistance on the kidney and vasculature
Artunc, F., Schleicher, E., Weigert, C., Fritsche, A., Stefan, N., & Häring, H.-U. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.145 · Cited by 462
Frank, N., Geor, R. J., Bailey, S. R., Durham, A. E., & Johnson, P. J. (2010) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.2010.0503.x · Cited by 421
The Role of Adipose Tissue and Lipotoxicity in the Pathogenesis of Type 2 Diabetes
Cusi, K. (2010) · Current Diabetes Reports · doi:10.1007/s11892-010-0122-6 · Cited by 300
Metadata
- Authors
- Muniyappa, R., Iantorno, M., & Quon, M. J.
- Venue
- Endocrinology and Metabolism Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 37
- Issue
- 3
- Pages
- 685-711
- ISSN
- 0889-8529 (ISSN-L)
- OpenAlex
- W2154231321
- Cited by
- 220
- References
- 24
- FWCI
- 7.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Muniyappa, R., Iantorno, M., & Quon, M. J. (2008). An Integrated View of Insulin Resistance and Endothelial Dysfunction. Endocrinology and Metabolism Clinics of North America. https://doi.org/10.1016/j.ecl.2008.06.001
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
