The Insulin-Like Growth Factor System in Bone

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

Jones, J. I. W., & Clemmons, D. R. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-1-3 · Cited by 4,488 · see citing works

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

Liu, J.-P., Baker, J. C., Perkins, A. S., Robertson, E. J., & Efstratiadis, A. (1993) · Cell · doi:10.1016/s0092-8674(05)80084-4 · Cited by 2,854 · see citing works

Insulin-like growth factors and their binding proteins: biological actions

Jones, J. I. (1995) · Endocrine Reviews · doi:10.1210/er.16.1.3 · Cited by 2,060 · see citing works

Cellular Actions of the Insulin-Like Growth Factor Binding Proteins

Firth, S. M., & Baxter, R. C. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0033 · Cited by 1,754 · see citing works

Normal growth and development in the absence of hepatic insulin-like growth factor I

Yakar, S., Liu, J., STANNARD, B. S., Butler, A. A., Accili, D., Sauer, B., & LeRoith, D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7324 · Cited by 1,418 · see citing works

Intrauterine Growth Retardation and Postnatal Growth Failure Associated with Deletion of the Insulin-Like Growth Factor I Gene

Woods, K. A., Camacho‐Hübner, C., Savage, M. O., & Clark, A. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610313351805 · Cited by 1,083 · see citing works

The Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily

Hwa, V., Oh, Y., & Rosenfeld, R. G. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.6.0382 · Cited by 1,076 · see citing works

Circulating levels of IGF-1 directly regulate bone growth and density

Yakar, S., Rosen, C. J., Beamer, W. G., Ackert‐Bicknell, C. L., Wu, Y., Liu, J., Ooi, G. T., Setser, J., Frystyk, J., Boisclair, Y. R., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15463 · Cited by 845 · see citing works

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2Preprint

Peng, X.-D., Xu, P.-Z., Chen, M.-L., Hahn-Windgassen, A., Skeen, J. E., Jacobs, J., Sundararajan, D., Chen, W. S., Crawford, S. E., Coleman, K. G., et al. (2003) · Genes & Development · doi:10.1101/gad.1089403 · Cited by 819 · see citing works

Circulating levels of IGF-1 directly regulate bone growth and density

Yakar, S., Rosen, C. J., Beamer, W. G., Ackert-Bicknell, C. L., Wu, Y., Liu, J.-L., Ooi, G. T., Setser, J., Frystyk, J., Boisclair, Y. R., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215463 · Cited by 739 · see citing works

Osteoblast-specific Knockout of the Insulin-like Growth Factor (IGF) Receptor Gene Reveals an Essential Role of IGF Signaling in Bone Matrix Mineralization

Zhang, M., Xuan, S., Bouxsein, M., Stechow, D. V., Akeno, N., Faugere, M.-C., Malluche, H. H., Zhao, G., Rosen, C. J., Efstratiadis, A., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208265200 · Cited by 696 · see citing works

IGF-I Receptor Mutations Resulting in Intrauterine and Postnatal Growth Retardation

Abuzzahab, M. J., Schneider, A., Goddard, A. D., Grigorescu, F., Lautier, C., Keller, E., Kieß, W., Klammt, J., Kratzsch, J., Osgood, D. P., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa010107 · Cited by 624 · see citing works

Growth Enhancement of Transgenic Mice Expressing Human Insulin-Like Growth Factor I*

Mathews, L. S., Hammer, R. E., Behringer, R. R., D’Ercole, A. J., Bell, G. I., Brinster, R. L., & Palmiter, R. D. (1988) · Endocrinology · doi:10.1210/endo-123-6-2827 · Cited by 477 · see citing works

The Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily

Hwa, V. (1999) · Endocrine Reviews · doi:10.1210/er.20.6.761 · Cited by 466 · see citing works

Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling

Fujita, T., Azuma, Y., Fukuyama, R., Hattori, Y., Yoshida, C. A., Koida, M., Ogita, K., & Komori, T. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200401138 · Cited by 462 · see citing works

Targeted Overexpression of Insulin-Like Growth Factor I to Osteoblasts of Transgenic Mice: Increased Trabecular Bone Volume without Increased Osteoblast Proliferation1

Zhao, G., Monier‐Faugere, M., Langub, M. C., Geng, Z., Nakayama, T., Pike, J. W., Chernausek, S. D., Rosen, C. J., Donahue, L.-R., Malluche, H. H., et al. (2000) · Endocrinology · doi:10.1210/endo.141.7.7585 · Cited by 358 · see citing works

Reduced bone mineral density in patients with adult onset growth hormone deficiency

Holmes, S. J., Economou, G., Whitehouse, R. W., Adams, J. E., & Shalet, S. M. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.3.8126140 · Cited by 340 · see citing works

Homozygous and Heterozygous Expression of a Novel Insulin-Like Growth Factor-I Mutation

Walenkamp, M. J. E., Karperien, M., Pereira, A. M., Hilhorst‐Hofstee, Y., van Doorn, J., Chen, J. W., Mohan, S., Denley, A., Forbes, B. E., van Duyvenvoorde, H. A., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1254 · Cited by 314 · see citing works

Requirement of BMP-2-induced Phosphatidylinositol 3-Kinase and Akt Serine/Threonine Kinase in Osteoblast Differentiation and Smad-dependent BMP-2 Gene Transcription

Ghosh‐Choudhury, N., Abboud, S. L., Nishimura, R., Celeste, A. J., Mahimainathan, L., & Choudhury, G. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205053200 · Cited by 299 · see citing works

Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover

Ogata, N., Chikazu, D., Kubota, N., Terauchi, Y., Tobe, K., Azuma, Y., Ohta, T., Kadowaki, T., Nakamura, K., & Kawaguchi, H. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9017 · Cited by 270 · see citing works

Association Between Insulin-Like Growth Factor I and Bone Mineral Density in Older Women and Men: The Framingham Heart Study

Langlois, J. A., Rosen, C. J., Visser, M., Hannan, M. T., Harris, T. B., Wilson, P. W. F., & Kiel, D. P. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.12.5308 · Cited by 267 · see citing works

The hormonal action of IGF1 in postnatal mouse growth

Στρατικόπουλος, Η., Szabolcs, M. J., Dragatsis, I., Klinakis, A., & Efstratiadis, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809223105 · Cited by 232 · see citing works

Insulin-like Growth Factors and Bone: The Osteoporosis Connection

Rosen, C. J., Donahue, L. R., & Hunter, S. J. (1994) · Experimental Biology and Medicine · doi:10.3181/00379727-206-43726 · Cited by 228 · see citing works

Low serum IGF-1 and occurrence of osteoporotic fractures in postmenopausal women

Garnero, P., Sornay‐Rendu, E., & Delmas, P. D. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05463-x · Cited by 205 · see citing works

Reduced bone mineral content in adult patients with growth hormone deficiency

Rosén, T., HANSSON, T. H., Granhed, H., Szücs, J., & Bengtsson, B. (1993) · European Journal of Endocrinology · doi:10.1530/acta.0.1290201 · Cited by 203 · see citing works

Role of IGF-I Signaling in Regulating Osteoclastogenesis

Wang, Y., Nishida, S., Elalieh, H. Z., Long, R. K., Halloran, B. P., & Bikle, D. D. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060610 · Cited by 199 · see citing works

The Skeletal Structure of Insulin-Like Growth Factor I-Deficient Mice

Bikle, D. D., Majumdar, S., Laib, A., Powell-Braxton, L., Rosen, C. J., Beamer, W. G., Nauman, E. A., Leary, C., & Halloran, B. P. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.12.2320 · Cited by 196 · see citing works

Effects of long-term treatment with growth hormone on bone and mineral metabolism in children with growth hormone deficiency

Saggese, G., Baroncelli, G. I., Bertelloni, S., Cinquanta, L., & Nero, G. D. (1993) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)83484-5 · Cited by 195 · see citing works

Effects of recombinant insulin-like growth factor-I and growth hormone on bone turnover in elderly women

Ghiron, L., Thompson, J. L., Holloway, L., Hintz, R. L., Butterfield, G. E., Hoffman, A. R., & Marcus, R. (1995) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650101203 · Cited by 180 · see citing works

A novel mutation in a patient with insulin-like growth factor 1 (IGF1) deficiency

Bonapace, G., Concolino, D., Formicola, S., & Strisciuglio, P. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.12.913 · Cited by 176 · see citing works

Short-term effects of recombinant human insulin-like growth factor I on bone turnover in normal women

Ebeling, P. R., Jones, J. D., O’Fallon, W. M., Janes, C. H., & Riggs, B. L. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.5.8077337 · Cited by 174 · see citing works

Lifelong accumulation of bone in mice lacking Pten in osteoblasts

Liu, X., Bruxvoort, K. J., Diegel, C. R., Liu, J., Cichowski, R., Monier‐Faugere, M., Bouxsein, M., Wan, C., Williams, B. O., & Clemens, T. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604153104 · Cited by 173 · see citing works

The insulin-like growth factor-I gene and osteoporosis: A critical appraisal

Niu, T., & Rosen, C. J. (2005) · Gene · doi:10.1016/j.gene.2005.07.016 · Cited by 171 · see citing works

IGF-I Regulates Osteoprotegerin (OPG) and Receptor Activator of Nuclear Factor-κB Ligandin Vitroand OPGin Vivo

Rubin, J. E., Ackert‐Bicknell, C. L., Zhu, L., Fan, X., Murphy, T. C., Nanes, M. S., Marcus, R., Holloway, L., Beamer, W. G., & Rosen, C. J. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020656 · Cited by 161 · see citing works

A Whole-Genome Linkage Scan Suggests Several Genomic Regions Potentially Containing Quantitative Trait Loci for Osteoporosis

Deng, H., Xu, F., Huang, Q., Shen, H., Deng, H., Conway, T., Liu, Y.-J., Liu, Y., Li, J., Zhang, H.-T., et al. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020474 · Cited by 140 · see citing works

Mutation at Cleavage Site of Insulin-Like Growth Factor Receptor in a Short-Stature Child Born with Intrauterine Growth Retardation

Kawashima, Y., Kanzaki, S., Yang, F., Kinoshita, T., Hanaki, K., Nagaishi, J.-I., Ohtsuka, Y., Hisatome, I., Ninomoya, H., Nanba, E., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1947 · Cited by 133 · see citing works

Genome Screen for Quantitative Trait Loci Contributing to Normal Variation in Bone Mineral Density: The Framingham Study

Karasik, D., Myers, R. H., Cupples, L. A., Hannan, M. T., GAGNON, D. R., Herbert, A. G., & Kiel, D. P. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.9.1718 · Cited by 127 · see citing works

Effects of Insulin-Like Growth Factor I (IGF-I) Therapy on Body Composition and Insulin Resistance in IGF-I Gene Deletion

Woods, K. A., Camacho‐Hübner, C., Bergman, R. N., Barter, D., Clark, A., & Savage, M. O. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.4.6495 · Cited by 121 · see citing works

Insulin-Like Growth Factor (IGF) Binding Protein-4 Is Both a Positive and Negative Regulator of IGF Activity in Vivo

Ning, Y., Schuller, A. G., Conover, C. A., & Pintar, J. E. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0536 · Cited by 120 · see citing works

Musculoskeletal Effects of the Recombinant Human IGF-I/IGF Binding Protein-3 Complex in Osteoporotic Patients with Proximal Femoral Fracture: A Double-Blind, Placebo-Controlled Pilot Study

Boonen, S., Rosen, C. J., Bouillon, R., Sommer, A., McKay, M. J., Rosen, D. M., Adams, S., Broos, P. L. O., Lenaerts, J. L., Raus, J., et al. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8426 · Cited by 118 · see citing works

Bone Mineral, Histomorphometry, and Body Composition in Adults with Growth Hormone Receptor Deficiency

Bachrach, L. K., Marcus, R., Ott, S. M., Rosenbloom, A. L., Vasconez, O., Martínez, V., Martinez, A. L., Rosenfeld, R. G., & Guevara‐Aguirre, J. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.3.415 · Cited by 112 · see citing works

Growth Inhibition in Giant Growth Hormone Transgenic Mice by Overexpression of Insulin-Like Growth Factor-Binding Protein-2

Hoeflich, A., Nedbal, S., Blum, W. F., Erhard, M., Lahm, H., Brem, G., Kolb, H. J., Wanke, R., & Wolf, E. (2001) · Endocrinology · doi:10.1210/endo.142.5.8149 · Cited by 106 · see citing works

Parallel Phosphatidylinositol-3 Kinase and p42/44 Mitogen-Activated Protein Kinase Signaling Pathways Subserve the Mitogenic and Antiapoptotic Actions of Insulin-Like Growth Factor I in Osteoblastic Cells

Grey, A. B., Chen, Q., Xu, X., Callon, K. E., & Cornish, J. (2003) · Endocrinology · doi:10.1210/en.2003-0350 · Cited by 102 · see citing works

Paracrine Overexpression of IGFBP-4 in Osteoblasts of Transgenic Mice Decreases Bone Turnover and Causes Global Growth Retardation

Zhang, M., Monier‐Faugere, M., Malluche, H. H., Rosen, C. J., Chernausek, S. D., & Clemens, T. L. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.5.836 · Cited by 101 · see citing works

Transgenic Mice Overexpressing Insulin-Like Growth Factor Binding Protein-5 Display Transiently Decreased Osteoblastic Function and Osteopenia

Devlin, R. D., Du, Z., Buccilli, V., Jorgetti, V., & CANALIS, E. M. (2002) · Endocrinology · doi:10.1210/en.2002-220129 · Cited by 95 · see citing works

Insulin-like growth factor system abnormalities in hepatitis C-associated osteosclerosis. Potential insights into increasing bone mass in adults.

Khosla, S., Hassoun, A. A. K., Baker, B. K., Liu, F., Zein, N. N., Whyte, M. P., Reasner, C. A., Nippoldt, T. B., Tiegs, R. D., Hintz, R. L., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1111 · Cited by 94 · see citing works

Targeted Overexpression of Insulin-Like Growth Factor I to Osteoblasts of Transgenic Mice: Increased Trabecular Bone Volume without Increased Osteoblast Proliferation

Zhao, G. (2000) · Endocrinology · doi:10.1210/en.141.7.2674 · Cited by 94 · see citing works

Umbilical Venous IGF-1 Concentration, Neonatal Bone Mass, and Body Composition

Javaid, M. K., Godfrey, K. M., Taylor, P., Shore, S., Breier, B. H., Arden, N. K., & Cooper, C. C. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.0301211 · Cited by 92 · see citing works

Clinical and Functional Characteristics of the Human Arg59Ter Insulin-Like Growth Factor I Receptor (IGF1R) Mutation: Implications for a Gene Dosage Effect of the Human IGF1R

Raile, K., Klammt, J., Schneider, A., Keller, A., Laue, S., Smith, R., Pfäffle, R. W., Kratzsch, J., Keller, E., & Kiess, W. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2146 · Cited by 81 · see citing works

A Potentially Deleterious Role of IGFBP-2 on Bone Density in Aging Men and Women

Amin, S., Riggs, B. L., Atkinson, E. J., Oberg, A. L., Melton, L. J., & Khosla, S. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040301 · Cited by 79 · see citing works

Perturbations in Bone Formation and Resorption in Insulin-Like Growth Factor Binding Protein-3 Transgenic Mice

Silha, J. V., Mishra, S., Rosen, C. J., Beamer, W. G., Turner, R. T., Powell, D. R., & Murphy, L. J. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.10.1834 · Cited by 79 · see citing works

Generation of a New Congenic Mouse Strain to Test the Relationships Among Serum Insulin-like Growth Factor I, Bone Mineral Density, and Skeletal Morphology In Vivo

Bouxsein, M., Rosen, C. J., Turner, C. H., Ackert, C. L., Shultz, K. L., Donahue, L. R., Churchill, G. A., Adamo, M. L., Powell, D. R., Turner, R. T., et al. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.4.570 · Cited by 79 · see citing works

IGF-I secreted by osteoblasts acts as a potent chemotactic factor for osteoblasts

Nakasaki, M., Yoshioka, K., Miyamoto, Y., Sasaki, T., Yoshikawa, H., & Itoh, K. (2008) · Bone · doi:10.1016/j.bone.2008.07.241 · Cited by 79 · see citing works

Postnatal growth and bone mass in mice with IGF-I haploinsufficiency

He, J., Rosen, C. J., Adams, D. J., & Kream, B. E. (2006) · Bone · doi:10.1016/j.bone.2005.11.021 · Cited by 79 · see citing works

Elevated serum levels of IGF-1 are sufficient to establish normal body size and skeletal properties even in the absence of tissue IGF-1

Elis, S., Courtland, H., Wu, Y., Rosen, C. J., Sun, H. B., Jepsen, K. J., Majeska, R. J., & Yakar, S. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.20 · Cited by 78 · see citing works

Subcutaneous administration of insulin-like growth factor (IGF)-II/IGF binding protein-2 complex stimulates bone formation and prevents loss of bone mineral density in a rat model of disuse osteoporosis

Conover, C. A., Johnstone, E. W., Turner, R. T., Evans, G. L., Ballard, F. J., Doran, P. M., & Khosla, S. (2002) · Growth Hormone & IGF Research · doi:10.1016/s1096-6374(02)00044-8 · Cited by 74 · see citing works

The Influence of an Insulin-Like Growth Factor I Gene Promoter Polymorphism on Hip Bone Geometry and the Risk of Nonvertebral Fracture in the Elderly: The Rotterdam Study

Rivadeneira, F., Houwing‐Duistermaat, J. J., Beck, T., Janssen, J. A. M. J. L., Albert Hofman, D., Pols, H. A. P., van Duijn, C. M., & Uitterlinden, A. G. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040405 · Cited by 73 · see citing works

Serum insulin-like growth factor binding protein-2 levels as an indicator of functional ability in elderly men

van den Beld, A. W., Blum, W., Pols, H., Grobbee, D. E., & Lamberts, S. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1480627 · Cited by 64 · see citing works

Association between an Insulin-Like Growth Factor I Gene Promoter Polymorphism and Bone Mineral Density in the Elderly: The Rotterdam Study

Rivadeneira, F., Houwing‐Duistermaat, J. J., Vaessen, N., Vergeer, J. M., Albert Hofman, D., Pols, H. A. P., van Duijn, C. M., & Uitterlinden, A. G. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021813 · Cited by 62 · see citing works

Sibling Pair Linkage and Association Studies between Bone Mineral Density and the Insulin-Like Growth Factor I Gene Locus1

Takács, I., Koller, D. L., Peacock, M., Christian, J. C., Hui, S. L., Conneally, P. M., Johnston, C. C., Foroud, T., & Econs, M. J. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.12.6179 · Cited by 60 · see citing works

Determinants of Bone Mineral Density and Spinal Fracture Risk in Postmenopausal Japanese Women

Nakaoka, D., Sugimoto, T., Kaji, H., Kanzawa, M., Yano, S., Yamauchi, M., Sugishita, T., & Chihara, K. (2001) · Osteoporosis International · doi:10.1007/s001980170075 · Cited by 58 · see citing works

The relationship among serum insulin-like growth factor-I, insulin-like growth factor-I gene polymorphism, and bone mineral density in postmenopausal women in Korea

Kim, J. G., Roh, K. R., & Lee, J. Y. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.120483 · Cited by 56 · see citing works

Insulin-like growth factor-I treatment of children with Laron syndrome (primary growth hormone insensitivity).

Laron, Z. (2008) · PubMed · Cited by 48 · see citing works

Are Adult Patients with Laron Syndrome Osteopenic? A Comparison between Dual-Energy X-Ray Absorptiometry and Volumetric Bone Densities

Benbassat, C. A., Eshed, V., Kamjin, M., & Laron, Z. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030623 · Cited by 41 · see citing works

Insulin-Like Growth Factor System Abnormalities in Hepatitis C-Associated Osteosclerosis

Khosla, S. (1998) · The Endocrinologist · doi:10.1097/00019616-199809000-00019 · Cited by 31 · see citing works

Sibling Pair Linkage and Association Studies between Bone Mineral Density and the Insulin-Like Growth Factor I Gene Locus

Takacs, I. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.12.4467 · Cited by 29 · see citing works

No major effect of the insulin-like growth factor I gene on bone mineral density in premenopausal Chinese women

Jiang, D., Shen, H., Li, M., Jiang, C., Yang, N., Zhu, J., Wu, Y., Qin, Y., Zhou, Q., & Deng, H. (2005) · Bone · doi:10.1016/j.bone.2005.01.013 · Cited by 15 · see citing works

Role of tumor microenvironment in cancer progression and therapeutic strategy

Wang, Q., Shao, X., Zhang, Y., Zhu, M., Wang, F. X. C., Mu, J., Li, J., Yao, H., & Chen, K. (2023) · Cancer Medicine · doi:10.1002/cam4.5698 · Cited by 462 · see citing works

Mechanistic investigations of the mitochondrial complex i inhibitor rotenone in the context of pharmacological and safety evaluation

Heinz, S., Freyberger, A., Lawrenz, B., Schladt, L., Schmuck, G., & Ellinger-Ziegelbauer, H. (2017) · Scientific Reports · doi:10.1038/srep45465 · Cited by 334 · see citing works

Resolution of inflammation in bone regeneration: From understandings to therapeutic applications

Newman, H., Shih, Y.-R. V., & Varghese, S. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121114 · Cited by 318 · see citing works

Molecular mechanisms and clinical management of cancer bone metastasis

Wang, M., Xia, F., Wei, Y., & Wei, X. (2020) · Bone Research · doi:10.1038/s41413-020-00105-1 · Cited by 200 · see citing works

Pubertal Timing, Bone Acquisition, and Risk of Fracture Throughout Life

Bonjour, J., & Chevalley, T. (2014) · Endocrine Reviews · doi:10.1210/er.2014-1007 · Cited by 145 · see citing works

Rehmannia glutinosa Libosch Extracts Prevent Bone Loss and Architectural Deterioration and Enhance Osteoblastic Bone Formation by Regulating the IGF-1/PI3K/mTOR Pathway in Streptozotocin-Induced Diabetic Rats

Gong, W., Zhang, N.-D., Cheng, G., Zhang, Q., He, Y., He, Y., Zhang, Q., Zhu, B., Zhang, Q., & Qin, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163964 · Cited by 131 · see citing works

Interaction of the endocrine system with inflammation: a function of energy and volume regulation

Straub, R. H. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4484 · Cited by 121 · see citing works

Potential modulatory mechanisms of action by long-chain polyunsaturated fatty acids on bone cell and chondrocyte metabolism

Abshirini, M., Ilesanmi-Oyelere, B. L., & Kruger, M. C. (2021) · Progress in Lipid Research · doi:10.1016/j.plipres.2021.101113 · Cited by 111 · see citing works

Aerobic Glycolysis in Osteoblasts

Esen, E., & Long, F. (2014) · Current Osteoporosis Reports · doi:10.1007/s11914-014-0235-y · Cited by 109 · see citing works

Osteoporosis and fractures in liver disease: Relevance, pathogenesis and therapeutic implications

Nakchbandi, I. A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i28.9427 · Cited by 105 · see citing works

Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation

Shi, Y., Chen, J., Karner, C. M., & Long, F. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1502301112 · Cited by 98 · see citing works

Bone metabolism in children and adolescents: main characteristics of the determinants of peak bone mass.

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Trabecular bone organoids: a micron-scale ‘humanised’ prototype designed to study the effects of microgravity and degeneration

Iordachescu, A., Hughes, E. A. B., Joseph, S., Hill, E. J., Grover, L. M., & Metcalfe, A. D. (2021) · npj Microgravity · doi:10.1038/s41526-021-00146-8 · Cited by 87 · see citing works

Osteoblast dysfunctions in bone diseases: from cellular and molecular mechanisms to therapeutic strategies

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Novel scaffold platforms for simultaneous induction osteogenesis and angiogenesis in bone tissue engineering: a cutting-edge approach

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Additional file 2 of Identification of bone morphogenetic protein 4 in the saliva after the placement of fixed orthodontic appliance

Grgurević, L., Novak, R., Salai, G., Trkulja, V., Hamzić, L. F., Popović, V. Z., & Božić, D. (2021) · Figshare · doi:10.6084/m9.figshare.14955903

Additional file 6 of Identification of bone morphogenetic protein 4 in the saliva after the placement of fixed orthodontic appliance

Grgurević, L., Novak, R., Salai, G., Trkulja, V., Hamzić, L. F., Popović, V. Z., & Božić, D. (2021) · Figshare · doi:10.6084/m9.figshare.14955915

Additional file 3 of Identification of bone morphogenetic protein 4 in the saliva after the placement of fixed orthodontic appliance

Grgurević, L., Novak, R., Salai, G., Trkulja, V., Hamzić, L. F., Popović, V. Z., & Božić, D. (2021) · Figshare · doi:10.6084/m9.figshare.14955906

Additional file 5 of Identification of bone morphogenetic protein 4 in the saliva after the placement of fixed orthodontic appliance

Grgurević, L., Novak, R., Salai, G., Trkulja, V., Hamzić, L. F., Popović, V. Z., & Božić, D. (2021) · Figshare · doi:10.6084/m9.figshare.14955912

Insulin-like growth factor I and bone mineral density: experience from animal models and human observational studies

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