The DOI matches its Crossref record; 226 of the 232 references it cites were found in a registry or an index.
Development of Adrenal Cortex Zonation
Open accessAbstract
The human adult adrenal cortex is composed of the zona glomerulosa (zG), zona fasciculata (zF), and zona reticularis (zR), which are responsible for production of mineralocorticoids, glucocorticoids, and adrenal androgens, respectively. The final completion of cortical zonation in humans does not occur until puberty with the establishment of the zR and its production of adrenal androgens; a process called adrenarche. The maintenance of the adrenal cortex involves the centripetal displacement and differentiation of peripheral Sonic hedgehog-positive progenitors cells into zG cells that later transition to zF cells and subsequently zR cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Mean HU scores for pheochromocytoma are 30 to 35 (197) with only 0.5% of pheochromocytoma having an unenhanced CT attenuation of ≤10 HU (97,197,198).”
From Adrenal incidentaloma (2020) · cites this paper as [97]
In the citing paper
“This maturational process generally begins at about age 6 years, several years before activation of the hypothalamic-pituitary-gonadal axis (gonadarche).9”
From Pubertal development and regulation (2016) · cites this paper as [9]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091 · cited 1×
“In order to expand its replicative potential, many cancers overexpress telomerase.(210) A recent study has shown that TERT, a gene that codes for the catalytic subunit of the telomerase enzyme, is frequently amplified in ACC.”
Vale, W., Spiess, J., Rivier, C., & Rivier, J. (1981) · Science · doi:10.1126/science.6267699 · Cited by 3,965
Vale, W., Spiess, J., RIVIER, C. L., & Rivier, J. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198205000-00013 · Cited by 3,904
Krude, H., Biebermann, H., Luck, W., Horn, R., Brabant, G. E., & Grüters, A. (1998) · Nature Genetics · doi:10.1038/509 · Cited by 1,769
Luo, X., Ikeda, Y., & Parker, K. L. (1994) · Cell · doi:10.1016/0092-8674(94)90211-9 · Cited by 1,631 · cited 2×
“of SF1 migrate dorsomedially to form the adrenal anlagen (adrenal primordial [AP] or adrenal fetal zone [FZ]), ultimately settling ventrolateral to the dorsal aorta.(3) At about 48 dpc in humans (E11.”
Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells
Gupta, P. B., Fillmore, C. M., Jiang, G., Shapira, S. D., Tao, K., Kuperwasser, C., & Lander, E. S. (2011) · Cell · doi:10.1016/j.cell.2011.07.026 · Cited by 1,475
Speiser, P. W., Azziz, R., Baskin, L. S., Ghizzoni, L., Hensle, T. W., Merke, D. P., Meyer-Bahlburg, H. F. L., Miller, W. L., Montori, V. M., Oberfield, S. E., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2631 · Cited by 1,468 · cited 1×
“The most common form of CAH is the 21-hydroxylase deficiency (CYP21A2), accounting for more than 95% of cases.(150) More than 100 mutations have been described in this disease and a strong genotype-phenotype correlation is observed.”
A cancer family syndrome in twenty-four kindreds.
Li, F. P., Fraumeni, J. F., Mulvihill, J. J., Blattner, W. A., Dreyfus, M., Tucker, M., & Miller, R. (1988) · PubMed · Cited by 1,293
Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution
Shackleton, M. J., Quintana, E., Fearon, E. R., & Morrison, S. J. (2009) · Cell · doi:10.1016/j.cell.2009.08.017 · Cited by 1,204
The insulin-like growth factor system and cancer
LeRoith, D., & Roberts, C. T. (2003) · Cancer Letters · doi:10.1016/s0304-3835(03)00159-9 · Cited by 1,124
Flagged first, then by citations
6 of the 232 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Baker, 1952, A comparison of the histological changes induced by experimental hyperadrenocorticalism and inanition, Recent Prog Horm Res, 7, 331
Cited by
Sorted by citations
Pubertal development and regulation
Abreu, A. P., & Kaiser, U. B. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00418-0 · Cited by 611
Sherlock, M., Scarsbrook, A., Abbas, A., Fraser, S., Limumpornpetch, P., Dineen, R., & Stewart, P. M. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa008 · Cited by 347
“5% of pheochromocytoma having an unenhanced CT attenuation of ≤10 HU (97,197,198).”
BackgroundAge-Related Autonomous Aldosteronism
Nanba, K., Vaidya, A., Williams, G. H., Zheng, I., Else, T., & Rainey, W. E. (2017) · Circulation · doi:10.1161/circulationaha.117.028201 · Cited by 192
Self-citationDevelopmental origins of the human hypothalamic-pituitary-adrenal axis
Howland, M. A., Sandman, C. A., & Glynn, L. M. (2017) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2017.1356222 · Cited by 192
Heinze, B., Fuß, C. T., Mulatero, P., Beuschlein, F., Reincke, M., Mustafa, M., Schirbel, A., Deutschbein, T., Williams, T. A., Rhayem, Y., et al. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.09975 · Cited by 170
Metadata
- Authors
- Xing, Y., Lerario, A. M., Rainey, W., & Hammer, G. D.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Hammer, Gary D.
- Venue
- Endocrinology and Metabolism Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 44
- Issue
- 2
- Pages
- 243-274
- ISSN
- 0889-8529 (ISSN-L)
- PMC
- PMC4486052
- OpenAlex
- W1605945857
- Cited by
- 174
- References
- 232
- Citations by year
- 2026: 16 · 2025: 11 · 2024: 15 · 2023: 23 · 2022: 14 · 2021: 20 · 2020: 15 · 2019: 20 · 2018: 16 · 2017: 10 · 2016: 10 · 2015: 2
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Endocrinology and Metabolism Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK020572, R01DK062027)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- adrenal cortex zonation, zona glomerulosa, zona fasciculata, zona reticularis, adrenarche, puberty, Sonic hedgehog, progenitor cells, adrenal androgens, glucocorticoids, mineralocorticoids, adrenal development
- MeSH terms
- Adrenal Cortex, Androgens, Cell Differentiation, Glucocorticoids, Humans, Mineralocorticoids, Puberty, Stem Cells, Zona Fasciculata, Zona Glomerulosa, Zona Reticularis, Hedgehog Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
