Metabolomics analysis explores the rescue to neurobehavioral disorder induced by maternal PM2.5 exposure in mice
Abstract
Reproductive epidemiological studies have suggested associations between perinatal exposure to fine particulate matter (PM 2.5 ) and adverse birth outcomes. To explore the effects of early prenatal exposure to PM 2.5 on subsequent generations, pregnant mice were exposed to PM 2.5 or filtered clean air in whole body dynamic exposure chambers for 14 consecutive days from gestation day (GD) 1.5 to GD15.5. Neurobehavioral tests showed that spontaneous locomotion and exploratory behaviors in the offspring were significantly enhanced in the open field test. Meanwhile, metabolomics analysis suggested activation of dopamine pathway while inhibition of glycine pathway in murine brains. Administration of the DRD4 antagonist, clozapine; or supplementation of glycine receptor agonist, taurine, to mice offspring attenuated the locomotor hyperactivities to levels indistinguishable from controls. These data provide strong evidence that maternal exposure to air pollution might increase the risk for neural disorders in the offspring during critical periods of brain development.
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Supplementation with a dopamine receptor antagonist and glycine receptor agonist attenuated adverse effects of PM exposure.
“Supplementation with a dopamine receptor antagonist and glycine receptor agonist attenuated adverse effects [117].”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [117]
Altered locomotor effects after PM exposure signify the role of dopamine pathway activation and glycine signaling inhibition.
“Findings related to altered locomotor effects also signify the role of dopamine pathway activation, as well as glycine signaling inhibition [112, 117].”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [117]
Cites
Fine particulate matter (PM2.5) in China at a city level
Zhang, Y.-L., & Cao, F. (2015) · Scientific Reports · doi:10.1038/srep14884 · Cited by 921 · see citing works
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Johnson, N. M., Hoffmann, A. R., Behlen, J. C., Lau, C., Pendleton, D., Harvey, N., Shore, R., Li, Y., Chen, J., Tian, Y., et al. (2021) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-021-00995-5 · Cited by 339 · see citing works
“Findings related to altered locomotor effects also signify the role of dopamine pathway activation, as well as glycine signaling inhibition [112, 117].”
Background
- Authors
- Cui, J., Fu, Y., Lu, R., Bi, Y., Zhang, L., Zhang, C., Aschner, M., Li, X., & Chen, R.
- Affiliations
- Southeast University (CN)
- Ministry of Education of the People's Republic of China (CN)
- Albert Einstein College of Medicine (US)
- Corresponding author
- Li, Xiaobo
- Chen, Rui
- Venue
- Ecotoxicology and Environmental Safety
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 169
- Pages
- 687-695
- ISSN
- 0147-6513 (ISSN-L)
- OpenAlex
- W2902879941
- Cited by
- 40
- References
- 1
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 7 · 2023: 5 · 2022: 10 · 2021: 6 · 2020: 5 · 2019: 2
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ecotoxicology and Environmental Safety (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Environmental Health Sciences (R01 ES020852, R01 ES07331, R01 ES10563)
- National Key Research and Development Program of China (2017YFC0211600, 2017YFC0211603)
- National Natural Science Foundation of China (81730088, 91743112, 91643109)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- PM2.5, air pollution, prenatal exposure, maternal exposure, neurobehavioral disorders, locomotor hyperactivity, dopaminergic pathways, DRD4, clozapine, taurine, glycine receptor, brain development, offspring, perinatal exposure
- MeSH terms
- Air Pollutants, Animals, Behavior, Animal, Brain, Female, Humans, Male, Motor Activity, Pregnancy, Prenatal Exposure Delayed Effects, Maternal Exposure, Mice, Particulate Matter, Metabolomics, Metabolome
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