RACK1, an excellent predictor for poor clinical outcome in oral squamous carcinoma, similar to Ki67
Abstract
Purpose The aim of this study was to evaluate the significance of RACK1 in predicting outcome for patients with oral squamous cell carcinoma (OSCC) compared with Ki67.Methods The expression of both RACK1 and Ki67 in 130 patients with OSCC was illustrated by using immunohistochemistry assay. Multiple logistic regression and Pearson's correlation coefficient were used. Recurrence versus non-recurrence of the malignant lesions was considered as the surrogate for clinical outcome of patients.Results Multivariable logistic regression showed that the elevated RACK1 immunostaining was a factor having great influence on OSCC prognosis. RACK1 staining was strongly related to that of Ki67. The area under the receiver operating characteristic curve for both biomarkers in predicting recurrence was 0.72 and 0.70 respectively, indicating an excellent discrimination for RACK1 as well as for Ki67.Conclusions These data indicate that increased RACK1 expression is an important outcome predictor for OSCC compared with Ki67.
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The in-house oral tissues were diagnosed as hyperkeratosis without dysplasia and their genetic profiles are closer to normal tissue than malignant tissue.
“The four were taken from three patients with an average age of 50, which were all diagnosed as hyperkeratosis without dysplasia by pathologists, just showing an increase in cell number in the spinous layer and/or in the basal/parabasal cell layers without cellular atypia, and its genetic profiles would be much more closed to normal tissue than malignant tissue22–24.”
From High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa (2020) · cites this paper as [24]
The in-house tissues came from a previous project that found no significant expression difference among common epithelial markers in past and other studies.
“which from our previous project found no significant expression difference among the common epithelial markers in our past study and other previous study22–24.”
From High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa (2020) · cites this paper as [24]
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- Authors
- Wang, Z., Zhang, B., Jiang, L., Zeng, X., Chen, Y., Feng, X., Guo, Y., & Chen, Q.
- Affiliations
- Sichuan University (CN)
- Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
- Corresponding author
- Chen, Qianming
- Venue
- European Journal of Cancer
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 45
- Issue
- 3
- Pages
- 490-496
- ISSN
- 0959-8049 (ISSN-L)
- OpenAlex
- W2087875641
- Cited by
- 59
- References
- 23
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 5 · 2020: 3 · 2019: 1 · 2018: 7 · 2017: 4 · 2016: 7 · 2015: 4 · 2014: 7 · 2013: 4 · 2012: 5
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Keywords
- RACK1, oral squamous cell carcinoma, Ki-67, prognostic factors, tumor recurrence, clinical outcome prediction, protein expression
- MeSH terms
- Receptors for Activated C Kinase, Adult, Carcinoma, Squamous Cell, Female, Humans, Male, Middle Aged, Mouth Mucosa, Mouth Neoplasms, Neoplasm Proteins, Neoplasm Recurrence, Local, Prognosis, Receptors, Cell Surface, Regression Analysis, Biomarkers, Tumor, Ki-67 Antigen
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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