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Cited by 83Mechanisms of cancer metastasisCancer Cells and MetastasisChemokine receptors and signaling

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The KISS1 metastasis suppressor: A good night kiss for disseminated cancer cells

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Beck, Benjamin H., Welch, Danny R.·2010·European Journal of Cancer
DOI 10.1016/j.ejca.2010.02.023PMC PMC3662025
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Abstract

Re-expression of KISS1 in tumor cell lines allows all antecedent steps of metastasis, but prevents colonization of secondary sites. Because tumor cells have already disseminated by the time of cancer diagnosis, KISS1 may represent a new opportunity for therapeutic intervention. Moreover, numerous clinical reports demonstrate that a loss or reduction of KISS1 expression in different human cancers inversely correlates with tumor progression, metastasis, and survival. Taken together, these observations compel the hypothesis that KISS1 could be of tremendous utility in controlling metastasis in a therapeutic context. In this review, we highlight some key findings from preclinical and clinical studies and discuss strategies whereby KISS1 may be exploited clinically to treat metastases.

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Research works printed but not linked: 42

  1. Bodenstine, 2008, Metastasis suppressors and the tumor microenvironment, Cancer Microenviron, 1, 1, 10.1007/s12307-008-0001-8 · DOI
  2. Vaidya, 2007, Metastasis suppressors and their roles in breast carcinoma, J Mamm Gland Biol Neopl, 12, 175, 10.1007/s10911-007-9049-1 · DOI
  3. Welch, 1994, Microcell-mediated transfer of chromosome 6 into metastatic human C8161 melanoma cells suppresses metastasis but does not inhibit tumorigenicity, Oncogene, 9, 255
  4. Lee, 1996, KiSS-1, a novel human malignant melanoma metastasis-suppressor gene, J Natl Cancer Inst, 88, 1731, 10.1093/jnci/88.23.1731 · DOI · Paper page
  5. Lee, 1997, Identification of highly expressed genes in metastasis-suppressed chromosome 6/human malignant melanoma hybrid cells using subtractive hybridization and differential display, Int J Cancer, 71, 1035, 10.1002/(SICI)1097-0215(19970611)71:6<1035::AID-IJC20>3.0.CO;2-B · DOI
  6. Lee, 1997, KiSS-1, a novel human malignant melanoma metastasis-suppressor gene, J Natl Cancer Inst, 89, 1549
  7. Lee, 1997, Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1, Cancer Res, 57, 2384
  8. Miele, 2000, Et al. A human melanoma metastasis-suppressor locus maps to 6q16.3–q23, Int J Cancer, 86, 524, 10.1002/(SICI)1097-0215(20000515)86:4<524::AID-IJC13>3.0.CO;2-W · DOI
  9. Shirasaki, 2001, Loss of expression of the metastasis suppressor gene KiSS1 during melanoma progression and its association with LOH of chromosome 6q16.3–q23, Cancer Res, 61, 7422
  10. Goldberg, 2003, Melanoma metastasis suppression by chromosome 6: Evidence for a pathway regulated by CRSP3 and TXNIP, Cancer Res, 63, 432
  11. Muir, 2001, AXOR12: A novel human G protein-coupled receptor, activated by the peptide KiSS-1, J Biol Chem, 276, 28969, 10.1074/jbc.M102743200 · DOI
  12. Ohtaki, 2001, Metastasis suppressor gene KiSS1 encodes peptide ligand of a G-protein-coupled receptor, Nature, 411, 613, 10.1038/35079135 · DOI
  13. Nash, 2006, The KISS1 metastasis suppressor: mechanistic insights and clinical utility, Front Biosci, 11, 647, 10.2741/1824 · DOI
  14. Nash, 2007, KISS1 metastasis suppressor secretion, multiple organ metastasis suppression, and maintenance of tumor dormancy, J Natl Cancer Inst, 99, 309, 10.1093/jnci/djk053 · DOI
  15. Jayasena, 2009, Kisspeptin offers a novel therapeutic target in reproduction, Curr Opin Invest Drugs, 10, 311
  16. Colledge, 2009, Kisspeptins and GnRH neuronal signalling, Trends Endocrinol Metab, 20, 115, 10.1016/j.tem.2008.10.005 · DOI
  17. Tomita, 2008, Development of novel G-protein-coupled receptor 54 agonists with resistance to degradation by matrix metalloproteinase, J Med Chem, 51, 7645, 10.1021/jm800930w · DOI
  18. Tomita, 2007, SAR and QSAR studies on the n-terminally acylated pentapeptide agonists for GPR54, J Med Chem, 50, 3222, 10.1021/jm070064l · DOI
  19. Roa, 2008, New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function, Front Neuroendocrinol, 29, 48, 10.1016/j.yfrne.2007.07.002 · DOI
  20. Tena-Sempere, 2008, Timeline: the role of kisspeptins in reproductive biology, Nat Med, 14, 1196, 10.1038/nm1108-1196 · DOI
  21. Gianetti, 2008, Kisspeptin and KISS1R: a critical pathway in the reproductive system, Reproduction, 136, 295, 10.1530/REP-08-0091 · DOI
  22. Horikoshi, 2003, Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans, J Clin Endocrin Metab, 88, 914, 10.1210/jc.2002-021235 · DOI
  23. Jiang, 2005, KiSS1 suppresses metastasis in human ovarian cancer via inhibition of protein kinase C alpha, Clin Exp Metastasis, 22, 369, 10.1007/s10585-005-8186-4 · DOI
  24. Kostadima, 2007, The missing kiss of life: Transcriptional activity of the metastasis suppressor gene KiSS1 in early breast cancer, Anticancer Res, 27, 2499
  25. Stark, 2004, Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases, J Cancer Res Clin Oncol, 131, 191, 10.1007/s00432-004-0629-9 · DOI
  26. Martin, 2005, KiSS-1 expression in human breast cancer, Clin Exp Metastasis, 22, 503, 10.1007/s10585-005-4180-0 · DOI
  27. Marot, 2007, High tumoral levels of Kiss1 and G-protein-coupled receptor 54 expression are correlated with poor prognosis of estrogen receptor-positive breast tumors, Endocr Relat Cancer, 14, 691, 10.1677/ERC-07-0012 · DOI
  28. Prentice, 2007, Kisspeptin and GPR54 immunoreactivity in a cohort of 518 patients defines favourable prognosis and clear cell subtype in ovarian carcinoma, BMC Med, 5, 33, 10.1186/1741-7015-5-33 · DOI
  29. Hata, 2007, Expression of metastin and a G-protein-coupled receptor (AXOR12) in epithelial ovarian cancer, Eur J Cancer, 43, 1452, 10.1016/j.ejca.2007.03.004 · DOI
  30. Dhar, 2004, Downregulation of KiSS-1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma, Int J Cancer, 111, 868, 10.1002/ijc.20357 · DOI
  31. Guan-Zhen, 2007, Reduced protein expression of metastasis-related genes (nm23, KISS1, KAI1 and p53) in lymph node and liver metastases of gastric cancer, Int J Exp Pathol, 88, 175, 10.1111/j.1365-2613.2006.00510.x · DOI
  32. Masui, 2004, Metastin and its variant forms suppress migration of pancreatic cancer cells, Biochem Biophys Res Comm, 315, 85, 10.1016/j.bbrc.2004.01.021 · DOI
  33. Nagai, 2009, Prognostic value of metastin expression in human pancreatic cancer, J Exp Clin Cancer Res, 28, 28, 10.1186/1756-9966-28-9 · DOI
  34. Katagiri, 2009, Clinical significance of plasma metastin level in pancreatic cancer patients, Oncol Rep, 21, 815
  35. Ikeguchi, 2004, Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT 7T 175) gene expression in esophageal squamous cell carcinoma, Clin Cancer Res, 10, 1379, 10.1158/1078-0432.CCR-1519-02 · DOI
  36. Ikeguchi, 2003, Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT 7T 175) gene expression in hepatocellular carcinoma, J Cancer Res Clin Oncol, 129, 531, 10.1007/s00432-003-0469-z · DOI
  37. Schmid, 2007, KiSS-1 overexpression as an independent prognostic marker in hepatocellular carcinoma: an immunohistochemical study, Virchows Arch, 450, 143, 10.1007/s00428-006-0352-9 · DOI
  38. Eccles, 2007, Metastasis: recent discoveries and novel treatment strategies, Lancet, 369, 1742, 10.1016/S0140-6736(07)60781-8 · DOI
  39. Smith, 2009, Learning therapeutic lessons from metastasis suppressor proteins, Nat Rev Cancer, 9, 253, 10.1038/nrc2594 · DOI
  40. Palmieri, 2005, Medroxyprogesterone acetate elevation of Nm23–H1 metastasis suppressor expression in hormone receptor-negative breast cancer, J Natl Cancer Inst, 97, 632, 10.1093/jnci/dji111 · DOI
  41. Dhillo, 2007, Kisspeptin-54 stimulates gonadotropin release most potently during the preovulatory phase of the menstrual cycle in women, J Clin Endocrin Metab, 92, 3958, 10.1210/jc.2007-1116 · DOI
  42. Dhillo, 2005, Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males, J Clin Endocrin Metab, 90, 6609, 10.1210/jc.2005-1468 · DOI · Paper page

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Metadata

Authors
Beck, B. H., & Welch, D. R.
Affiliations
University of Alabama (US)
Corresponding author
Welch, Danny R.
ORCID
Venue
European Journal of Cancer
Publisher
Elsevier BV
Published
2010-05
Volume
46
Issue
7
Pages
1283-1289
ISSN
0959-8049 (ISSN-L)
DOI
10.1016/j.ejca.2010.02.023
PMC
PMC3662025
OpenAlex
W1987952385
Cited by
83
References
2
Citations by year
2026: 4 · 2025: 3 · 2023: 7 · 2022: 6 · 2020: 7 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 6 · 2013: 10 · 2012: 8
FWCI
0.73
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • European Journal of Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Foundation for Cancer Research
  • U.S. Public Health Service
  • National Cancer Institute (CA134981, CA087728, R01CA087728, R01CA062168, R01CA134981, CA062168)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Keywords
KISS1, metastasis suppressor, metastasis, disseminated tumor cells, tumor colonization, metastasis treatment, tumor progression
MeSH terms
Receptors, Kisspeptin-1, Animals, Chromosomes, Human, Pair 6, Humans, Neoplastic Cells, Circulating, Neoplasm Metastasis, Gene Expression Regulation, Neoplastic, Genes, Tumor Suppressor, Tumor Suppressor Proteins, Receptors, G-Protein-Coupled, Mice, Kisspeptins

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