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Cited by 331

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Mortality in patients with cancer and coronavirus disease 2019: A systematic review and pooled analysis of 52 studies

Open access
Saini, Kamal S., Tagliamento, Marco, Lambertini, Matteo, McNally, Richard, Romano, Marco, Leone, Manuela, Curigliano, Giuseppe, de Azambuja, Evandro·2020·European Journal of Cancer

Abstract

Background Patients with COVID-19 who have underlying malignancy have a higher mortality rate compared with those without cancer, although the magnitude of such excess risk is not clearly defined. We performed a systematic review and pooled analysis to provide precise estimates of the mortality rate among patients with both cancer and COVID-19. Methods A systematic literature search involving peer reviewed publications, preprints, and conference proceedings up to July 16, 2020 was performed. The primary endpoint was the case fatality rate (CFR), defined as rate of death among patients with cancer and COVID-19. The CFR was assessed with a random effects model, which was used to derive a pooled CFR and its 95% confidence interval (CI). Results 52 studies, involving a total of 18,650 patients with both COVID-19 and cancer were selected for the pooled analysis. A total of 4,243 deaths were recorded in this population. The probability of death was 25·6% (95% CI 22·0% to 29·9%; I2=48·9%) in this patient population. Conclusions Patients with cancer who develop COVID-19 have high probability of mortality. Appropriate and aggressive preventive measures must be taken to reduce the risk of COVID-19 in patients with cancer, and to optimally manage those who do contract the infection.

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Crossref · 10.1016/j.ejca.2020.08.011

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Metadata

Authors
Saini, K. S., Tagliamento, M., Lambertini, M., McNally, R., Romano, M., Leone, M., Curigliano, G., & de Azambuja, E.
Venue
European Journal of Cancer
Publisher
Elsevier BV
Published
2020-11
Volume
139
Pages
43-50
ISSN
0959-8049 (ISSN-L)
OpenAlex
W3082480386
Cited by
331
References
54
FWCI
9.44
Type
journal article
Language
en
Open access
bronze

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