Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak
Open accessAbstract
Abstract The novel COVID-19 outbreak has affected more than 200 countries and territories as of March 2020. Given that patients with cancer are generally more vulnerable to infections, systematic analysis of diverse cohorts of patients with cancer affected by COVID-19 is needed. We performed a multicenter study including 105 patients with cancer and 536 age-matched noncancer patients confirmed with COVID-19. Our results showed COVID-19 patients with cancer had higher risks in all severe outcomes. Patients with hematologic cancer, lung cancer, or with metastatic cancer (stage IV) had the highest frequency of severe events. Patients with nonmetastatic cancer experienced similar frequencies of severe conditions to those observed in patients without cancer. Patients who received surgery had higher risks of having severe events, whereas patients who underwent only radiotherapy did not demonstrate significant differences in severe events when compared with patients without cancer. These findings indicate that patients with cancer appear more vulnerable to SARS-CoV-2 outbreak. Significance: Because this is the first large cohort study on this topic, our report will provide much-needed information that will benefit patients with cancer globally. As such, we believe it is extremely important that our study be disseminated widely to alert clinicians and patients. This article is highlighted in the In This Issue feature, p. 747
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Cancer patients who continue active treatment during the pandemic are among vulnerable groups because they are at higher risk of being infected and showing more severe symptoms and even death when infected.
“They are among the vulnerable groups because they are at higher risk of being infected and showing more severe symptoms and even death when infected.[13]”
From Psychological Distress of Breast Cancer Survivors During the COVID-19 Pandemic and Related Factors: A Controlled Study. (2023) · cites this paper as [13]
The Introduction says people with cancer are generally more susceptible to infections, but the study does not establish that patients continuing active treatment have a higher risk of acquiring SARS-CoV-2. The Discussion reports more severe outcomes and a nearly threefold higher death rate among infected patients with cancer than among infected patients without cancer. It also says outcomes did not differ between cancer patients receiving and not receiving active treatment. (LLM, conf=0.86)
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Cites
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21492 · Cited by 84,109 · see citing works
Clinical characteristics of coronavirus disease 2019 in China
Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Liu, L., Shan, H., Lei, C.-L., Hui, D. S. C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2002032 · Cited by 30,246 · see citing works
Self-citationChen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30211-7 · Cited by 21,415 · see citing works
Self-citationCancer statistics in China, 2015
Chen, W., Zheng, R., Baade, P. D., Zhang, S., Zeng, H., Bray, F., Jemal, A., Yu, X. Q., & He, J. (2016) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21338 · Cited by 17,038 · see citing works
Wu, Z., & McGoogan, J. M. (2020) · JAMA · doi:10.1001/jama.2020.2648 · Cited by 17,016 · see citing works
Yang, X., Yu, Y., Xu, J., Shu, H., Xia, J., Liu, H., Wu, Y., Zhang, L., Yu, Z., Fang, M., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30079-5 · Cited by 10,066 · see citing works
Self-citationPathological findings of COVID-19 associated with acute respiratory distress syndrome
Xu, Z., Shi, L., Wang, Y., Zhang, J., Huang, L., Zhang, C., Liu, S., Zhao, P., Liu, H., Zhu, L., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30076-x · Cited by 8,545 · see citing works
Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China
Liang, W., Guan, W., Chen, R., Wang, W., Li, J., Xu, K., Li, C., Ai, Q., Lu, W., Liang, H., et al. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(20)30096-6 · Cited by 4,384 · see citing works
Raje, N. S., & Anderson, K. C. (2000) · Current Treatment Options in Oncology · doi:10.1007/s11864-000-0017-x · Cited by 2,164 · see citing works
Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury
Russell, C. D., Millar, J. E., & Baillie, J. K. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30317-2 · Cited by 2,007 · see citing works
Zhang, L., Zhu, F., Xie, L., Wang, C., Wang, J., Chen, R., Jia, P., Guan, H. Q., Li, P., Chen, Y., et al. (2020) · Annals of Oncology · doi:10.1016/j.annonc.2020.03.296 · Cited by 1,498 · see citing works
Self-citationAdult haemophagocytic syndrome
Ramos‐Casals, M., Brito‐Zerón, P., López‐Guillermo, A., Khamashta, M. A., & Bosch, X. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61048-x · Cited by 1,445 · see citing works
A review of cancer immunotherapy toxicity
Kennedy, L. B., & Salama, A. K. S. (2020) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21596 · Cited by 1,376 · see citing works
Lung pathology of fatal severe acute respiratory syndrome
Nicholls, J. M., Poon, L. L., Lee, K. C., Ng, W. F., Lai, S. T., Leung, C. Y., Chu, C. M., Hui, P. K., Mak, K. L., Lim, W., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13413-7 · Cited by 1,076 · see citing works
Raab, M. S., Podar, K., Breitkreutz, I., Richardson, P. G. G., & Anderson, K. C. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60221-x · Cited by 695 · see citing works
Clinical characteristics of 82 cases of death from COVID-19
Zhang, B., Zhou, X., Qiu, Y., Feng, F., Feng, J., Feng, J., Zhu, H., Hu, K., JiaSheng, L., Liu, Z., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235458 · Cited by 688 · see citing works
[Report of cancer epidemiology in China, 2015].
Zheng, R., Sun, K., Zhang, S., Zeng, H., Zou, X., Chen, R., Gu, X., Wei, W., & He, J. (2019) · PubMed · doi:10.3760/cma.j.issn.0253-3766.2019.01.005 · Cited by 643 · see citing works
Improving immune–vascular crosstalk for cancer immunotherapy
Huang, Y., Kim, B. Y. S., Chan, C. K., Hahn, S. M., Weissman, I. L., & Jiang, W. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.145 · Cited by 563 · see citing works
Risk of COVID-19 for patients with cancer
Xia, Y., Jin, R., Zhao, J., Li, W., & Shen, H. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(20)30150-9 · Cited by 436 · see citing works
Risk of COVID-19 for patients with cancer
Wang, H., & Zhang, L. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(20)30149-2 · Cited by 427 · see citing works
Self-citationSevere cytokine release syndrome in a patient receiving PD‐1‐directed therapy
Rotz, S. J., Leino, D. G., Szabo, S., Mangino, J. L., Turpin, B. K., & Pressey, J. G. (2017) · Pediatric Blood & Cancer · doi:10.1002/pbc.26642 · Cited by 157 · see citing works
Lainey, É., Wolfromm, A., Sukkurwala, A. Q., Micol, J., Fenaux, P., Galluzzi, L., Kepp, O., & Kroemer, G. (2013) · Cell Cycle · doi:10.4161/cc.26016 · Cited by 44 · see citing works
Guillermin, Y., Lopez, J., Chabane, K., Hayette, S., Bardel, C., Salles, G., Sujobert, P., & Huet, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041251 · Cited by 13 · see citing works
Flagged first, then by citations
4 of the 27 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study
Kuderer, N. M., Choueiri, T. K., Shah, D. P., Shyr, Y., Rubinstein, S. M., Rivera, D. R., Shete, S., Hsu, C.-Y., Desai, A., de Lima Lopes, G., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31187-9 · Cited by 1,726 · see citing works
Lee, L. Y., Cazier, J.-B., Angelis, V., Arnold, R., Bisht, V., Campton, N. A., Chackathayil, J., Cheng, V. W., Curley, H. M., Fittall, M. W., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31173-9 · Cited by 1,103 · see citing works
Terpos, E., Engelhardt, M. M., Cook, G., Gay, F., Mateos, M., Ntanasis‐Stathopoulos, I., van de Donk, N. W. C. J., Avet‐Loiseau, H., Hájek, R., Vangsted, A. J., et al. (2020) · Leukemia · doi:10.1038/s41375-020-0876-z · Cited by 736 · see citing works
Determinants of COVID-19 disease severity in patients with cancer
Robilotti, E. V., Babady, N. E., Mead, P. A., Rolling, T., Pérez-Johnston, R., Bernardes, M., Bogler, Y., Caldararo, M. D., Figueroa, C. J., Glickman, M. S., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0979-0 · Cited by 634 · see citing works
Lee, L. Y. W., Cazier, J., Starkey, T., Briggs, S., Arnold, R. R., Bisht, V., Booth, S. W., Campton, N. A., Cheng, V. W. T., Collins, G. P., et al. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(20)30442-3 · Cited by 575 · see citing works
Booth, A., Reed, A. B., Ponzo, S., Yassaee, A., Aral, M., Plans, D., Labrique, A. B., & Mohan, D. (2021) · PLoS ONE · doi:10.1371/journal.pone.0247461 · Cited by 553 · see citing works
COVID-19 in Immunocompromised Hosts: What We Know So Far
Fung, M., & Babik, J. M. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa863 · Cited by 518 · see citing works
CD8+ T cells contribute to survival in patients with COVID-19 and hematologic cancer
Bange, E. M., Han, N. A., Wileyto, P., Kim, J. Y., Gouma, S., Robinson, J., Greenplate, A. R., Hwee, M. A., Porterfield, F., Owoyemi, O., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01386-7 · Cited by 519 · see citing works
Lai, A. G., Pasea, L., Banerjee, A., Hall, G., Denaxas, S., Chang, W. H., Katsoulis, M., Williams, B., Pillay, D., Noursadeghi, M., et al. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-043828 · Cited by 447 · see citing works
Sharma, A., Bhatt, N. S., Martin, A. S., Abid, M. B., Bloomquist, J., Chemaly, R. F., Dandoy, C. E., Gauthier, J., Gowda, L., Perales, M., et al. (2021) · The Lancet Haematology · doi:10.1016/s2352-3026(20)30429-4 · Cited by 354 · see citing works
Saini, K. S., Tagliamento, M., Lambertini, M., McNally, R., Romano, M., Leone, M., Curigliano, G., & de Azambuja, E. (2020) · European Journal of Cancer · doi:10.1016/j.ejca.2020.08.011 · Cited by 332 · see citing works
Grivas, P. D., Khaki, A. R., Wise-Draper, T. M., French, B. C., Hennessy, C., Hsu, C., Shyr, Y., Li, X., Choueiri, T. K., Painter, C., et al. (2021) · Annals of Oncology · doi:10.1016/j.annonc.2021.02.024 · Cited by 307 · see citing works
Managing cancer patients during the COVID-19 pandemic: an ESMO multidisciplinary expert consensus
Curigliano, G., Banerjee, S., Cervantes, A. M. R., Garassino, M. C., Garrido, P., Girard, N., Haanen, J. B. A. G., Jordan, K., Lordick, F., Machiels, J. P., et al. (2020) · Annals of Oncology · doi:10.1016/j.annonc.2020.07.010 · Cited by 306 · see citing works
Self-citationAllergic disorders and susceptibility to and severity of COVID-19: A nationwide cohort study
Yang, J. M., Koh, H. Y., Moon, S. Y., Yoo, I. K., Ha, E. K., You, S., Kim, S. Y., Yon, D. K., & Lee, S. W. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.08.008 · Cited by 285 · see citing works
Self-citationCOVID-19 and Cancer: Current Challenges and Perspectives
Bakouny, Z., Hawley, J. E., Choueiri, T. K., Peters, S., Rini, B. I., Warner, J. L., & Painter, C. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.09.018 · Cited by 273 · see citing works
COVID-19 in patients with lung cancer
Luo, J. D., Rizvi, H. A., Preeshagul, I. R., Egger, J. V., Hoyos, D., Bandlamudi, C., McCarthy, C. G., Falcon, C. J., Schoenfeld, A. J., Arbour, K. C., et al. (2020) · Annals of Oncology · doi:10.1016/j.annonc.2020.06.007 · Cited by 268 · see citing works
Scarfò, L., Chatzikonstantinou, T., Rigolin, G. M., Quaresmini, G., Motta, M., Vitale, C., Garcia-Marco, J. A., Hernández‐Rivas, J., Mirás, F., Baile, M., et al. (2020) · Leukemia · doi:10.1038/s41375-020-0959-x · Cited by 264 · see citing works
Impact of COVID-19 on the thyroid gland: an update
Scappaticcio, L., Pitoia, F., Esposito, K., Piccardo, A., & Trimboli, P. (2020) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-020-09615-z · Cited by 270 · see citing works
Chemotherapy and COVID-19 Outcomes in Patients With Cancer
Jee, J., Foote, M. B., Lumish, M. A., Stonestrom, A. J., Wills, B., Narendra, V. K., Avutu, V., Murciano‐Goroff, Y. R., Chan, J. E., Derkach, A., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.20.01307 · Cited by 256 · see citing works
Belsky, J. A., Tullius, B. P., Lamb, M. G., Sayegh, R., Stanek, J. R., & Auletta, J. J. (2021) · Journal of Infection · doi:10.1016/j.jinf.2021.01.022 · Cited by 239 · see citing works
Impact of PD-1 Blockade on Severity of COVID-19 in Patients with Lung Cancers
Luo, J., Rizvi, H. A., Egger, J. V., Preeshagul, I. R., Wolchok, J. D., & Hellmann, M. D. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0596 · Cited by 234 · see citing works
COVID-19 in cancer patients: risk, clinical features, and management
Liu, C., Zhao, Y., Okwan-Duodu, D. K., Basho, R. K., & Cui, X. (2020) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2020.0289 · Cited by 231 · see citing works
Glasbey, J. C., Nepogodiev, D., Simoes, J. F. F., Omar, O. M., Li, E., Venn, M. L., PGDME, Chaar, M. K. A., Capizzi, V., Chaudhry, D., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.20.01933 · Cited by 225 · see citing works
Lee, S. W., Ha, E. K., Yeniova, A. Ö., Moon, S. Y., Kim, S. Y., Koh, H. Y., Yang, J. M., Jeong, S. J., Moon, S. J., Cho, J. Y., et al. (2020) · Gut · doi:10.1136/gutjnl-2020-322248 · Cited by 221 · see citing works
Self-citationTreskova, M., Haas, L., Reda, S. A., Pilic, A., Borodova, A., Karimi, K., Koch, J., Nygren, T. M., Scholz, S. M., Schönfeld, V., et al. (2021) · BMC Medicine · doi:10.1186/s12916-021-02058-6 · Cited by 219 · see citing works
Westblade, L. F., Brar, G. S., Pinheiro, L. C., Paidoussis, D., Rajan, M., Martin, P., Goyal, P., Sepulveda, J. L., Zhang, L., George, G., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.09.007 · Cited by 217 · see citing works
Self-citationDandachi, D., Geiger, G., Montgomery, M. W., Karmen-Tuohy, S., Golzy, M., Antar, A. A. R., Llibre, J. M., Camazine, M. N., de Santiago, A. D., Carlucci, P. M., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1339 · Cited by 215 · see citing works
Priority COVID-19 Vaccination for Patients with Cancer while Vaccine Supply Is Limited
Ribas, A., Sengupta, R., Locke, T., Zaidi, S. K., Campbell, K. M., Carethers, J. M., Jaffee, E. M., Wherry, E. J., Soria, J., & DʼSouza, G. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1817 · Cited by 194 · see citing works
Zhang, H., Han, H., He, T., Labbe, K. E., Hernández, A. V., Chen, H., Velcheti, V., Stebbing, J., & Wong, K. (2020) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djaa168 · Cited by 195 · see citing works
Lassau, N., Ammari, S., Chouzenoux, É., Gortais, H., Hérent, P., Devilder, M., Soliman, S., Meyrignac, O., Talabard, M.-P., Lamarque, J.-P., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20657-4 · Cited by 187 · see citing works
COVID-19: Unmasking Emerging SARS-CoV-2 Variants, Vaccines and Therapeutic Strategies
Raman, R., Patel, K. J., & Ranjan, K. (2021) · Biomolecules · doi:10.3390/biom11070993 · Cited by 186 · see citing works
Hanson, K. E., Caliendo, A. M., Arias, C. A. D., Hayden, M. K., Englund, J. A., Lee, M. J., Loeb, M. B., Patel, R., Alayli, A. E., Altayar, O., et al. (2021) · Clinical Infectious Diseases · doi:10.1093/cid/ciab048 · Cited by 181 · see citing works
Meng, Y., Lu, W., Guo, E., Liu, J., Yang, B., Wu, P., Lin, S., Peng, T., Fu, Y., Li, F., et al. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00907-0 · Cited by 179 · see citing works
Coronavirus Disease 2019 as Cause of Viral Sepsis: A Systematic Review and Meta-Analysis*
Karakike, E., Giamarellos‐Bourboulis, E. J., Kyprianou, M., Fleischmann-Struzek, C., Pletz, M. W., Netea, M. G., Reinhart, K., & Kyriazopoulou, E. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005195 · Cited by 182 · see citing works
Impact of the coronavirus disease 2019 pandemic on cancer treatment: the patients’ perspective
de Joode, K., Dumoulin, D. W., Engelen, V., Bloemendal, H. J., Verheij, M., van Laarhoven, H. W. M., Dingemans, I., Dingemans, A. C., & van der Veldt, A. A. M. (2020) · European Journal of Cancer · doi:10.1016/j.ejca.2020.06.019 · Cited by 179 · see citing works
Clinical Portrait of the SARS-CoV-2 Epidemic in European Patients with Cancer
Pinato, D. J., Zambelli, A., Bower, M., Sng, C. C. T., Salazar, R., Bertuzzi, A. F., Brunet, J., Mesı́a, R., Seguí, E., Biello, F., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0773 · Cited by 179 · see citing works
Chidambaram, V., Tun, N. L., Haque, W. Z., Majella, M. G., Sivakumar, R. K., Kumar, A., Hsu, A. T., Ishak, I. A., Nur, A. A., Ayeh, S. K., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241541 · Cited by 176 · see citing works
Self-citationCOVID-19 in cancer patients: clinical characteristics and outcome—an analysis of the LEOSS registry
on behalf of the LEOSS Study Group, Rüthrich, M. M., Gießen-Jung, C., Borgmann, S., Classen, A. Y., Dolff, S., Grüner, B., Hanses, F., Isberner, N., Köhler, P., et al. (2020) · Annals of Hematology · doi:10.1007/s00277-020-04328-4 · Cited by 169 · see citing works
Lièvre, A., Turpin, A., Ray-Coquard, I. L., Malicot, K. L., Thariat, J., Ahle, G., Neuzillet, C., Paolettí, X., Bouché, O., Aldabbagh, K., et al. (2020) · European Journal of Cancer · doi:10.1016/j.ejca.2020.09.035 · Cited by 160 · see citing works
Bernabe-Ramirez, C., Velázquez, A. I., Olazagasti, C., Bergerot, C. D., Bergerot, P. G., Cruz, J. C., Riaño, I., Adaniel, C., Ramirez, F., Anampa, J., et al. (2022) · JCO Global Oncology · doi:10.1200/go.21.00251 · Cited by 172 · see citing works
Risk factors and outcome of COVID-19 in patients with hematological malignancies
Piñana, J. L., Martino, R., García‐García, I., Parody, R., Morales, M. D., Callejo, G. B., Gómez-Catalán, I., Coll, R., de la Fuente, I., Luna, A., et al. (2020) · Experimental Hematology and Oncology · doi:10.1186/s40164-020-00177-z · Cited by 155 · see citing works
The Risk and Prognosis of COVID-19 Infection in Cancer Patients
ElGohary, G. M., Hashmi, S. K., Styczyński, J., Kharfan‐Dabaja, M. A., Alblooshi, R. M., de la Cámara, R., Mohmed, S., Alshaibani, A., Cesaro, S., El-Aziz, N. A., et al. (2020) · Hematology/Oncology and Stem Cell Therapy · doi:10.1016/j.hemonc.2020.07.005 · Cited by 147 · see citing works
Severity of COVID-19 in patients with lung cancer: evidence and challenges
Passaro, A., Bestvina, C. M., Velez, M. A., Garassino, M. C., Garon, E. B., & Peters, S. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-002266 · Cited by 146 · see citing works
A Systematic Review and Meta-Analysis of Cancer Patients Affected by a Novel Coronavirus
Venkatesulu, B. P., Chandrasekar, V. T., Girdhar, P., Advani, P. G., Sharma, A., Elumalai, T., Hsieh, R. C.-E., Elghazawy, H. I., Verma, V., & Krishnan, S. (2021) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkaa102 · Cited by 149 · see citing works
Sex differences in SARS-CoV-2 infection rates and the potential link to prostate cancer
Chakravarty, D., Nair, S. S., Hammouda, N., Ratnani, P., Gharib, Y., Wagaskar, V. G., Mohamed, N., Lundon, D., Dovey, Z. S., Kyprianou, N., et al. (2020) · Communications Biology · doi:10.1038/s42003-020-1088-9 · Cited by 142 · see citing works
Wang, B., Oekelen, O. V., Mouhieddine, T. H., Valle, D. M. D., Richter, J. R., Cho, H. J., Richard, S., Chari, A., Gnjatic, S., Mérad, M., et al. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00934-x · Cited by 148 · see citing works
Sharafeldin, N., Bates, B. A., Song, Q., Madhira, V., Yan, Y., Dong, S., Lee, E., Kuhrt, N., Shao, Y. R., Liu, F., et al. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.21.01074 · Cited by 139 · see citing works
Prolonged SARS-CoV-2 Infection in Patients with Lymphoid Malignancies
Lee, C. Y., Shah, M. K., Hoyos, D., Solovyov, A., Douglas, M., Taur, Y., Maslak, P. G., Babady, N. E., Greenbaum, B., Kamboj, M., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-1033 · Cited by 132 · see citing works
The immuno-oncological challenge of COVID-19
Derosa, L., Melenotte, C., Griscelli, F., Gachot, B., Marabelle, A., Kroemer, G., & Zitvogel, L. (2020) · Nature Cancer · doi:10.1038/s43018-020-00122-3 · Cited by 131 · see citing works
The outcome of COVID‐19 in patients with hematological malignancy
Yiğenoğlu, T. N., Ata, N., Altuntaş, F., Başçı, S., Dal, M. S., Korkmaz, S., Namdaroğlu, S., Baştürk, A., Hacıbekiroğlu, T., Doğu, M. H., et al. (2020) · Journal of Medical Virology · doi:10.1002/jmv.26404 · Cited by 129 · see citing works
Keller, M. D., Harris, K. M., Jensen-Wachspress, M. A., Kankate, V. V., Lang, H., Lazarski, C. A., Durkee-Shock, J. R., Lee, P., Chaudhry, K., Webber, K., et al. (2020) · Blood · doi:10.1182/blood.2020008488 · Cited by 122 · see citing works
COVID-19 Severity and Outcomes in Patients With Cancer: A Matched Cohort Study
Brar, G. S., Pinheiro, L. C., Shusterman, M., Swed, B., Reshetnyak, E., Soroka, O., Chen, F., Yamshon, S., Vaughn, J. L., Martin, P., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.20.01580 · Cited by 127 · see citing works
COVID-19 and Cancer Comorbidity: Therapeutic Opportunities and Challenges
Pathania, A. S., Prathipati, P., Abdul, B. A., Chava, S. P., Katta, S. S., Gupta, S. C., Gangula, P. R., Pandey, M. K., Durden, D. L., Byrareddy, S. N., et al. (2020) · Theranostics · doi:10.7150/thno.51471 · Cited by 129 · see citing works
Desai, A. P., Gupta, R., Advani, S., Ouellette, L., Kuderer, N. M., Lyman, G. H., & Li, A. (2020) · Cancer · doi:10.1002/cncr.33386 · Cited by 128 · see citing works
Favorable outcomes of COVID-19 in recipients of hematopoietic cell transplantation
Shah, G. L., DeWolf, S., Lee, Y. J., Tamari, R., Dahi, P. B., Lavery, J. A., Ruiz, J. D., Devlin, S. M., Cho, C., Peled, J. U., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci141777 · Cited by 121 · see citing works
Geng, H.-W., Yin, F., Zhang, Z., Gong, X., & Yang, Y. K. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.634874 · Cited by 119 · see citing works
Self-citationYang, L., Chai, P., Yu, J., & Fan, X. (2021) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2020.0559 · Cited by 117 · see citing works
Infections due to dysregulated immunity: an emerging complication of cancer immunotherapy
Morelli, T., Fujita, K., Redelman‐Sidi, G., & Elkington, P. T. (2021) · Thorax · doi:10.1136/thoraxjnl-2021-217260 · Cited by 117 · see citing works
A systematic review and meta-analysis: the effect of active cancer treatment on severity of COVID-19
Yekedüz, E., Utkan, G., & Ürün, Y. (2020) · European Journal of Cancer · doi:10.1016/j.ejca.2020.09.028 · Cited by 114 · see citing works
Albiges, L. K., Foulon, S., Bayle, A., Gachot, B., Pommeret, F., Willekens, C., Stoclin, A., Merad-Boudia, M., Griscelli, F., Lacroix, L., et al. (2020) · Nature Cancer · doi:10.1038/s43018-020-00120-5 · Cited by 115 · see citing works
Hematological Abnormalities in COVID-19: A Narrative Review
Rahman, A., Niloofa, R., Jayarajah, U., Mel, S. D., Abeysuriya, V., & Seneviratne, S. L. (2021) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.20-1536 · Cited by 115 · see citing works
COVID-19 Emergence and Social and Health Determinants in Colorado: A Rapid Spatial Analysis
Ramírez, I. J., & Lee, J. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17113856 · Cited by 113 · see citing works
Cancer and COVID-19: Unmasking their ties
Addeo, A., & Friedlaender, A. (2020) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2020.102041 · Cited by 113 · see citing works
Risk Factors of Severe COVID-19: A Review of Host, Viral and Environmental Factors
Zsichla, L., & Müller, V. (2023) · Viruses · doi:10.3390/v15010175 · Cited by 113 · see citing works
Targeting Androgen Regulation of TMPRSS2 and ACE2 as a Therapeutic Strategy to Combat COVID-19
Deng, Q., Rasool, R. U., Russell, R. M., Natesan, R., & Asangani, I. A. (2020) · iScience · doi:10.1016/j.isci.2021.102254 · Cited by 104 · see citing works
Skalny, A. V., Lima, T. R. R., Ke, T., Zhou, J., Bornhorst, J., Alekseenko, S. I., Aaseth, J., Anesti, O., Sarigiannis, D. A., Tsatsakis, A. M., et al. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111809 · Cited by 101 · see citing works
Thakkar, A., Pradhan, K., Jindal, S., Cui, Z., Rockwell, B., Shah, A. P., Packer, S. H., Sica, R. A., Sparano, J. A., Goldstein, D. Y., et al. (2021) · Nature Cancer · doi:10.1038/s43018-021-00191-y · Cited by 101 · see citing works
Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
Behl, T., Sharma, A., Sharma, L. K., Sehgal, A., Zengin, G., Brata, R. D., Frățilă, O., & BUNGAU, S. G. (2020) · Biomedicines · doi:10.3390/biomedicines8120571 · Cited by 100 · see citing works
Links between Infections, Lung Cancer, and the Immune System
Budişan, L., Zănoagă, O., Braicu, C., Pîrlog, R., Covaliu, B. F., Eşanu, V., Korban, S. S., & Berindan‐Neagoe, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179394 · Cited by 102 · see citing works
COVID-19 and Thyroid Diseases: A Bidirectional Impact
Duntas, L. H., & Jonklaas, J. (2021) · Journal of the Endocrine Society · doi:10.1210/jendso/bvab076 · Cited by 93 · see citing works
Liu, C., Wang, K., Zhang, M., Hu, X., Hu, T., Liu, Y., Hu, Q., Wu, S., & Yue, J. (2021) · npj Precision Oncology · doi:10.1038/s41698-020-00139-y · Cited by 92 · see citing works
Self-citationKhoury, E. G., Nevitt, S. J., Madsen, W. R., Turtle, L. C. W., Davies, G., & Palmieri, C. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.10880 · Cited by 85 · see citing works
Cancer inpatients with COVID-19: A report from the Brazilian National Cancer Institute
de Melo, A. C., Thuler, L. C. S., da Silva, J. L., de Albuquerque, L. Z., Pecego, A. C., Rodrigues, L. D. O. R., da Conceição, M. S., Garrido, M. M., Mendes, G. L. Q., Pereira, A. C. P. M., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241261 · Cited by 89 · see citing works
Elkrief, A., Desîlets, A., Papneja, N., Cvetkovic, L., Groleau, C., Lakehal, Y. A., Shbat, L., Richard, C., Malo, J., Belkaïd, W., et al. (2020) · European Journal of Cancer · doi:10.1016/j.ejca.2020.08.017 · Cited by 79 · see citing works
Hultcrantz, M. L., Richter, J. R., Rosenbaum, C. A., Patel, D., Smith, E. L., Korde, N., Lu, S. X., Mailankody, S., Shah, U. A., Lesokhin, A. M., et al. (2020) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-20-0102 · Cited by 89 · see citing works
Cancer and Risk of COVID-19 Through a General Community Survey
Lee, K. A., Ma, W., Sikavi, D. R., Drew, D. A., Nguyen, L. H., Bowyer, R. C. E., Cardoso, M. J., Fall, T., Freidin, M. B., Gomez, M. F., et al. (2020) · The Oncologist · doi:10.1634/theoncologist.2020-0572 · Cited by 80 · see citing works
Ligumsky, H., Safadi, E., Etan, T., Vaknin, N., Waller, M., Croll, A., Nikolaevski‐Berlin, A., Greenberg, I., Halperin, T., Wasserman, A., et al. (2021) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djab174 · Cited by 80 · see citing works
Treating Leukemia in the Time of COVID-19
Paul, S., Rausch, C. R., Jain, N., Kadia, T. M., Ravandi, F., Dinardo, C. D., Welch, M. A., Dabaja, B. S., Daver, N. G., Garcia‐Manero, G., et al. (2020) · Acta Haematologica · doi:10.1159/000508199 · Cited by 78 · see citing works
Short and Long-Term Impact of COVID-19 Infection on Previous Respiratory Diseases
Chiner‐Vives, E., Cordovilla, R., de la Rosa, D., Clemente, M. M. G., Alonso, J. L. I., Otero, R., de Llano, L. P., Sellares-Torres, J., & de Granda‐Orive, J. I. (2022) · Archivos de Bronconeumología · doi:10.1016/j.arbres.2022.03.011 · Cited by 80 · see citing works
Vivarelli, S., Falzone, L., Grillo, C. M., Scandurra, G., Torino, F., & Libra, M. (2020) · Cancers · doi:10.3390/cancers12082237 · Cited by 75 · see citing works
Endothelial cells and SARS-CoV-2: An intimate relationship
Barbosa, L. C., Gonçalves, T. L., de Araújo, L. P., Rosário, L., & Ferrer, V. P. (2021) · Vascular Pharmacology · doi:10.1016/j.vph.2021.106829 · Cited by 76 · see citing works
COVID-19 and androgen-targeted therapy for prostate cancer patients
Bhowmick, N. A., Oft, J. R., Dorff, T. B., Pal, S. K., Agarwal, N., Figlin, R. A., Posadas, E. M., Freedland, S. J., & Gong, J. (2020) · Endocrine Related Cancer · doi:10.1530/erc-20-0165 · Cited by 74 · see citing works
When hematologic malignancies meet COVID-19 in the United States: Infections, death and disparities
Wang, Q., Berger, N. A., & Xu, R. (2020) · Blood Reviews · doi:10.1016/j.blre.2020.100775 · Cited by 75 · see citing works
Digital Health Applications in Oncology: An Opportunity to Seize
Parikh, R. B., Basen-Enquist, K. M., Bradley, C. J., Estrin, D. L., Levy, M. A., Lichtenfeld, J. L., Malin, B., McGraw, D., Meropol, N. J., Oyer, R. A., et al. (2022) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djac108 · Cited by 78 · see citing works
de Joode, K., Dumoulin, D. W., Tol, J., Westgeest, H. M., Beerepoot, L. V., van den Berkmortel, F. W. P. J., Mutsaers, P. G. N. J., van Diemen, N. G. J., Visser, O. J., Hoop, E. O., et al. (2020) · European Journal of Cancer · doi:10.1016/j.ejca.2020.09.027 · Cited by 75 · see citing works
Risk Factors and Mortality of COVID-19 in Patients With Lymphoma: A Multicenter Study
Regalado‐Artamendi, I., Ubieto, A. J., Hernández‐Rivas, J., Navarro, B., Núñez, L., Alaez, C., Córdoba, R., Peñalver, F., Cannata, J., Estival, P., et al. (2021) · HemaSphere · doi:10.1097/hs9.0000000000000538 · Cited by 80 · see citing works
Fox, T. A., Troy‐Barnes, E., Kirkwood, A. A., Chan, W. Y., Day, J. W., Chavda, S. J., Kumar, E. A., David, K., Tomkins, O. M., Sanchez, E., et al. (2020) · British Journal of Haematology · doi:10.1111/bjh.17027 · Cited by 72 · see citing works
Cancer Care Disparities during the COVID-19 Pandemic: COVID-19 and Cancer Outcomes Study
Schmidt, A. L., Bakouny, Z., Bhalla, S., Steinharter, J. A., Tremblay, D. A., Awad, M. M., Kessler, A. J., Haddad, R. I., Evans, M., Busser, F. J., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.10.023 · Cited by 72 · see citing works
Withaferin A: a potential therapeutic agent against COVID-19 infection
Straughn, A. R., & Kakar, S. S. (2020) · Journal of Ovarian Research · doi:10.1186/s13048-020-00684-x · Cited by 70 · see citing works
de Azambuja, E., Brandão, M., Wildiers, H. P. M. W., Laenen, A., Aspeslagh, S., Fontaine, C., Collignon, J., Lybaert, W., Verheezen, J., Rutten, A., et al. (2020) · ESMO Open · doi:10.1136/esmoopen-2020-000947 · Cited by 71 · see citing works
Chung, D. J., Shah, G. L., Devlin, S. M., Ramanathan, L. V., Doddi, S., Pessin, M. S., Hoover, E., Marcello, L. T., Young, J. C., Boutemine, S. R., et al. (2021) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-21-0139 · Cited by 69 · see citing works
SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases
Murugan, A. K., & Alzahrani, A. S. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s332705 · Cited by 72 · see citing works
Mortality risk of COVID-19 in elderly males with comorbidities: a multi-country study
Li, G., Liu, Y., Jing, X., Wang, Y., Miao, M., Li, T., Zhou, Z., Xie, Y., Huang, Y., Lei, J., et al. (2020) · Aging · doi:10.18632/aging.202456 · Cited by 68 · see citing works
Self-citationCOVID-19-related outcomes in immunocompromised patients: A nationwide study in Korea
Baek, M. S., Lee, M., Kim, W., Choi, J. C., & Jung, S. (2021) · PLoS ONE · doi:10.1371/journal.pone.0257641 · Cited by 66 · see citing works
SARS-CoV-2 and cancer: Are they really partners in crime?
van Dam, P. A., Huizing, M. T., Mestach, G., Dierckxsens, S., Tjalma, W. A. A., Trinh, X. B., Papadimitriou, K., Altıntaş, S., Vermorken, J. B., Vulsteke, C., et al. (2020) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2020.102068 · Cited by 65 · see citing works
Vivarelli, S., Falzone, L., Torino, F., Scandurra, G., Russo, G. L., Bordonaro, R., Pappalardo, F., Spandidos, D. A., Raciti, G., & Libra, M. (2020) · International Journal of Oncology · doi:10.3892/ijo.2020.5159 · Cited by 64 · see citing works
Cancer Patients’ Willingness to Take COVID-19 Vaccination: A Nationwide Multicenter Survey in Korea
Chun, J. Y., Kim, S. I., Park, E. Y., Park, S., Koh, S.-J., Cha, Y., Yoo, H. J., Joung, J. Y., Yoon, H. M., Eom, B. W., et al. (2021) · Cancers · doi:10.3390/cancers13153883 · Cited by 65 · see citing works
Tagliamento, M., Agostinetto, E., Bruzzone, M., Ceppi, M., Saini, K. S., de Azambuja, E., Punie, K., Westphalen, C. B., Morgan, G., Pronzato, P., et al. (2021) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2021.103365 · Cited by 64 · see citing works
Cancer and COVID-19: Analysis of Patient Outcomes
Aboueshia, M., Hussein, M. H., Attia, A. S., Swinford, A., Miller, P., Omar, M., Toraih, E. A., Saba, N. S., Safah, H. F., Duchesne, J. C., et al. (2021) · Future Oncology · doi:10.2217/fon-2021-0121 · Cited by 64 · see citing works
Han, S., Zhuang, Q., Chiang, J., Tan, S. H., Chua, G. W. Y., Xie, C., Chua, M. L. K., Soon, Y. Y., & Yang, V. S. (2022) · BMJ Open · doi:10.1136/bmjopen-2020-044661 · Cited by 60 · see citing works
- Authors
- Dai, M., Liu, D., Liu, M., Zhou, F., Li, G., Chen, Z., Zhang, Z., You, H., Wu, M., Zheng, Q., Xiong, Y., Xiong, H., Wang, C., Chen, C., Xiong, F., Zhang, Y., Peng, Y., Ge, S., Zhen, B., Yu, T., Wang, L., Wang, H., Liu, Y., Chen, Y., Mei, J., Gao, X., Li, Z., Gan, L., He, C., Li, Z., Shi, Y., Qi, Y., Yang, J., Tenen, D. G., Chai, L., Mucci, L. A., Santillana, M., & Cai, H.
- Affiliations
- Zhongnan Hospital of Wuhan University (CN)
- Boston Children's Hospital (US)
- Brigham and Women's Hospital (US)
- Wuhan Union Hospital (CN)
- Central Hospital of Wuhan (CN)
- Huanggang Central Hospital (CN)
- Guangzhou Medical University (CN)
- Tongji Hospital (CN)
- 16Department of Radiology, Hubei Cancer Hospital, Wuhan, Hubei, China.
- Hubei Cancer Hospital (CN)
- Renmin Hospital of Wuhan University (CN)
- 19Department of Oncology, Wuhan Puren Hospital, Wuhan, Hubei, China.
- Xianning Central Hospital (CN)
- The Central Hospital of Xiao gan (CN)
- 22Department of Obstetrics and Gynecology, The People's Hospital of Huangmei, Huangmei, Hubei, China.
- Hubei University of Medicine (CN)
- Harvard University (US)
- Corresponding author
- Liu, Miao
- Santillana, Mauricio
- Cai, Hongbing
- ORCID
- Venue
- Cancer Discovery
- Published
- 2020-06-01
- Volume
- 10
- Issue
- 6
- Pages
- 783-791
- ISSN
- 2159-8274 (ISSN-L)
- 2159-8290
- PMC
- PMC7309152
- OpenAlex
- W3015599879
- Cited by
- 1,589
- References
- 27
- Citations by year
- 2026: 16 · 2025: 55 · 2024: 90 · 2023: 218 · 2022: 354 · 2021: 494 · 2020: 356 · 2019: 1 · 2018: 2 · 2014: 1
- FWCI
- 128.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Discovery (publishedVersion)
- SSRN Electronic Journal (acceptedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (8197103302/H16)
- Singapore Ministry of Health's National Medical Research Council (MOH-STaR18nov-0002)
- NIH NHLBI (P01HL095489)
- Xiu Research Fund
- Institutional Ethics Board of Zhongnan Hospital of Wuhan University (2020029)
- Topics
- Health Sciences › Medicine › Oncology › COVID-19 and healthcare impacts
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Obstetrics and Gynecology › COVID-19 Impact on Reproduction
- Keywords
- COVID-19 pandemic, SARS-CoV-2, cancer patients, disease severity, hematologic malignancies, lung cancer, metastatic cancer, radiotherapy, infection susceptibility
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Aged, China, Disease Outbreaks, Female, Humans, Intensive Care Units, Male, Middle Aged, Neoplasms, Pneumonia, Viral, Respiration, Artificial, Cohort Studies, Coronavirus Infections, Pandemics
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