Cardiovascular disease after cancer therapy
Open accessAbstract
Improvements in treatment and earlier diagnosis have both contributed to increased survival for many cancer patients. Unfortunately, many treatments carry a risk of late effects including cardiovascular diseases (CVDs), possibly leading to significant morbidity and mortality. In this paper we describe current knowledge of the cardiotoxicity arising from cancer treatments, outline gaps in knowledge, and indicate directions for future research and guideline development, as discussed during the 2014 Cancer Survivorship Summit organised by the European Organisation for Research and Treatment of Cancer (EORTC). Better knowledge is needed of the late effects of modern systemic treatments and of radiotherapy to critical structures of the heart, including the effect of both radiation dose and volume of the heart exposed. Research elucidating the extent to which treatments interact in causing CVD, and the mechanisms involved, as well as the extent to which treatments may increase CVD indirectly by increasing cardiovascular risk factors is also important. Systematic collection of data relating treatment details to late effects is needed, and great care is needed to obtain valid and generalisable results. Better knowledge of these cardiac effects will contribute to both primary and secondary prevention of late complications where exposure to cardiotoxic treatment is unavoidable. Also surrogate markers would help to identify patients at increased risk of cardiotoxicity. Evidence-based screening guidelines for CVD following cancer are also needed. Finally, risk prediction models should be developed to guide primary treatment choice and appropriate follow up after cancer treatment.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Alberti, K. G. M. M., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., Fruchart, J.-C., James, W. P. T., Loria, C. M., & Smith, S. C. (2009) · Circulation · doi:10.1161/circulationaha.109.192644 · Cited by 14,860 · see citing works
Ahmed, A., Jorna, T., & Bhandari, S. (2016) · The Nephron journals/Nephron journals · doi:10.1159/000447068 · Cited by 11,782 · see citing works
Slamon, D. J., Leyland-Jones, B., Shak, S., Fuchs, H., Paton, V., Bajamonde, A., Fleming, T., Eiermann, W., Wolter, J., Pegram, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103153441101 · Cited by 11,500 · see citing works
ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012
Authors/Task Force Members, McMurray, J. J. V., Adamopoulos, S., Anker, S. D., Auricchio, A., Böhm, M., Dickstein, K., Falk, V., Filippatos, G., Fonseca, C., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs104 · Cited by 6,879 · see citing works
Trastuzumab plus Adjuvant Chemotherapy for Operable HER2-Positive Breast Cancer
Romond, E. H., Perez, E. A., Bryant, J., Suman, V. J., Geyer, C. E., Davidson, N. E., Tan-Chiu, E., Martino, S., Paik, S., Kaufman, P. A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa052122 · Cited by 5,355 · see citing works
Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer
Piccart-Gebhart, M. J., Procter, M., Leyland-Jones, B., Goldhirsch, A., Untch, M., Smith, I., Gianni, L., Baselga, J., Bell, R., Jackisch, C., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa052306 · Cited by 5,084 · see citing works
Self-citationTrastuzumab-Induced Hepatotoxicity: A Case Report
Vucicevic, D., Carey, E. J., & Karlin, N. J. (2013) · Breast Care · doi:10.1159/000346844 · Cited by 4,432 · see citing works
Risk of Ischemic Heart Disease in Women after Radiotherapy for Breast Cancer
Darby, S. C., Ewertz, M., McGale, P., Bennet, A. M., Blom-Goldman, U., Brønnum, D., Correa, C., Cutter, D., Gagliardi, G., Gigante, B., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1209825 · Cited by 3,974 · see citing works
Self-citationDarby, S. C., McGale, P., Correa, C. R., Taylor, C., Arriagada, R., Clarke, M. J., Cutter, D. J., Davies, C., Ewertz, M., Godwin, J., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)61629-2 · Cited by 3,942 · see citing works
Self-citationAdjuvant Trastuzumab in HER2-Positive Breast Cancer
Slamon, D. J., EIERMANN, W., Robert, N. J., Pieńkowski, T., Martín, M., Press, M. F., Mackey, J. R., Glaspy, J. A., Chan, A., Pawlicki, M., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa0910383 · Cited by 2,779 · see citing works
Risk Factors for Doxorubicin-lnduced Congestive Heart Failure
Hoff, D. D. V., LAYARD, M. W., BASA, P., DAVIS, H. L., HOFF, A. L. V., ROZENCWEIG, M., & MUGGIA, F. M. (1979) · Annals of Internal Medicine · doi:10.7326/0003-4819-91-5-710 · Cited by 2,388 · see citing works
Identification of the molecular basis of doxorubicin-induced cardiotoxicity
Zhang, S., Liu, X., Bawa‐Khalfe, T., Lu, L., Lyu, Y. L., Liu, L. F., & Yeh, E. T. H. (2012) · Nature Medicine · doi:10.1038/nm.2919 · Cited by 1,959 · see citing works
Cardiac Dysfunction in the Trastuzumab Clinical Trials Experience
Seidman, A. D., Hudis, C. A., Pierri, M. K., Shak, S., Paton, V. E., Ashby, M. A., Murphy, M., Stewart, S. J., & Keefe, D. L. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.5.1215 · Cited by 1,560 · see citing works
Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer
Keating, N. L., O'Malley, A. J., & Smith, M. R. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.06.2497 · Cited by 1,455 · see citing works
Radiation Dose–Volume Effects in the Heart
Gagliardi, G., Constine, L. S., Moiseenko, V., Correa, C. R., Pierce, L. J., Allen, A. M., & Marks, L. B. (2010) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2009.04.093 · Cited by 1,232 · see citing works
Preston, D. L., Shimizu, Y., Pierce, D. A., Suyama, A., & Mabuchi, K. (2003) · Radiation Research · doi:10.1667/rr3049 · Cited by 1,172 · see citing works
Mulrooney, D. A., Yeazel, M. W., Kawashima, T. I., Mertens, A. C., Mitby, P. A., Stovall, M., Donaldson, S. S., Green, D. M., Sklar, C. A., Robison, L. L., et al. (2009) · BMJ · doi:10.1136/bmj.b4606 · Cited by 1,171 · see citing works
Anthracycline-Induced Cardiomyopathy
Cardinale, D. M., Colombo, A., Lamantia, G., Colombo, N., Civelli, M., Giacomi, G. D., Rubino, M., Veglia, F., Fiorentini, C., & Cipolla, C. M. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.03.095 · Cited by 1,110 · see citing works
Darby, S. C., McGale, P., Taylor, C. W., & Peto, R. (2005) · The Lancet Oncology · doi:10.1016/s1470-2045(05)70251-5 · Cited by 1,049 · see citing works
Self-citationCuzick, J. M., Stewart, H., Rutqvist, L. E., Houghton, J., Edwards, R., Redmond, C. K., Peto, R., Baum, M., Fisher, B., & Høst, H. (1994) · Journal of Clinical Oncology · doi:10.1200/jco.1994.12.3.447 · Cited by 888 · see citing works
Long-Term Risk of Cardiovascular Disease in 10-Year Survivors of Breast Cancer
Hooning, M. J., Botma, A., Aleman, B. M. P., Baaijens, M. H. A., Bartelink, H. G. M. M., Klijn, J. G. M., Taylor, C., & van Leeuwen, F. E. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djk064 · Cited by 860 · see citing works
Self-citationSecond Cancers Among 40 576 Testicular Cancer Patients: Focus on Long-term Survivors
Travis, L. B., Fosså, S. D., Schonfeld, S. J., McMaster, M. L., Lynch, C. F., Storm, H. H., Hall, P. N., Holowaty, E. J., Andersen, A., Pukkala, ., et al. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji278 · Cited by 823 · see citing works
Tan-Chiu, E., Yothers, G., Romond, E. H., Geyer, C. E., Ewer, M. S., Keefe, D. L., Shannon, R. P., Swain, S. M., Brown, A. M., Fehrenbacher, L., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.02.4091 · Cited by 801 · see citing works
Smith, L. A., Cornelius, V. R., Plummer, C., Levitt, G., Verrill, M. W., Canney, P. A., & Jones, A. L. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-337 · Cited by 753 · see citing works
Factors Affecting Late Mortality From Heart Disease After Treatment of Hodgkin's Disease
Hancock, S. L. (1993) · JAMA · doi:10.1001/jama.1993.03510160067031 · Cited by 747 · see citing works
Late cardiotoxicity after treatment for Hodgkin lymphoma
Aleman, B. M. P., van den Belt‐Dusebout, A. W., Bruin, M. L. D., Veer, M. B. V., Baaijens, M. H. A., de Boer, J. P., Hart, A. A. M., Klokman, W. J., Kuenen, M. A., Ouwens, G. M., et al. (2006) · Blood · doi:10.1182/blood-2006-07-034405 · Cited by 743 · see citing works
Self-citationMertens, A. C., Liu, Q., Neglia, J. P., Wasilewski, K., Leisenring, W. M., Armstrong, G. T., Robison, L. L., & Yasui, Y. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn310 · Cited by 730 · see citing works
Long-Term Cause-Specific Mortality of Patients Treated for Hodgkin’s Disease
Aleman, B. M. P., van den Belt‐Dusebout, A. W., Klokman, W. J., Veer, M. B. V., Bartelink, H. G. M. M., & van Leeuwen, F. E. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.07.131 · Cited by 708 · see citing works
Self-citationPulmonary Arterial Hypertension in Patients Treated by Dasatinib
Montani, D., Bergot, E., Günther, S., Savale, L., Bergeron, A., BOURDIN, A. A., Bouvaist, H., Canuet, M., Pison, C. M., Macro, M., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.079921 · Cited by 658 · see citing works
Hull, M. C. (2003) · JAMA · doi:10.1001/jama.290.21.2831 · Cited by 645 · see citing works
Trastuzumab-Induced Cardiotoxicity: Clinical and Prognostic Implications of Troponin I Evaluation
Cardinale, D. M., Colombo, A., Torrisi, R., Sandri, M. T., Civelli, M., Salvatici, M., Lamantia, G., Colombo, N., Cortinovis, S., Dessanai, M. A., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.27.3615 · Cited by 638 · see citing works
Radiation-Related Heart Disease: Current Knowledge and Future Prospects
Darby, S. C., Cutter, D. J., Boerma, M., Constine, L. S., Fajardo, L. F., Kodama, K., Mabuchi, K., Marks, L. B., Mettler, F. A., Pierce, L. J., et al. (2010) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2009.09.064 · Cited by 621 · see citing works
Self-citationTrastuzumab containing regimens for early breast cancer
Moja, L., Tagliabue, L., Balduzzi, S., Parmelli, E., Pistotti, V., Guarneri, V., & D’Amico, R. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006243.pub2 · Cited by 605 · see citing works
Specht, L., Yahalom, J., Illidge, T., Berthelsen, A. K., Constine, L. S., Eich, H. T., Girinsky, T., Hoppe, R. T., Mauch, P., Mikhaeel, N. G., et al. (2013) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2013.05.005 · Cited by 582 · see citing works
Self-citationKy, B., Putt, M. E., Sawaya, H., French, B. C., Januzzi, J. L., Sebag, I. A., Plana, J. C., Cohen, V., Banchs, J. A., Carver, J. R., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.10.061 · Cited by 567 · see citing works
Risk of Cardiac Death After Adjuvant Radiotherapy for Breast Cancer
Giordano, S. H., Kuo, Y., Freeman, J. L., Buchholz, T. A., Hortobágyi, G. N., & Goodwin, J. S. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji067 · Cited by 551 · see citing works
Shimizu, Y., Kodama, K., Nishi, N., Kasagi, F., Suyama, A., Soda, M., Grant, E. J., Sugiyama, H., Sakata, R., Moriwaki, H., et al. (2010) · BMJ · doi:10.1136/bmj.b5349 · Cited by 531 · see citing works
Cancer drugs and the heart: importance and management
Suter, T. M., & Ewer, M. S. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs181 · Cited by 474 · see citing works
Self-citationRole of Cancer Treatment in Long-Term Overall and Cardiovascular Mortality After Childhood Cancer
Tukenova, M., Guibout, C., Oberlin, O., Doyon, F., Mousannif, A., Haddy, N., Guérin, S., Pacquement, H., Aouba, A., Hawkins, M., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2008.20.2267 · Cited by 452 · see citing works
Swerdlow, A. J., Higgins, C. D., Smith, P., Cunningham, D., Hancock, B. W., Horwich, A., Hoskin, P., Lister, A. T., Radford, J. A., Rohatiner, A. Z. S., et al. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djk029 · Cited by 448 · see citing works
Ng, A. K., Bernardo, M. P., Weller, E. A., Backstrand, K. H., Silver, B., Marcus, K. C., Tarbell, N. J., Friedberg, J. W., Canellos, G. P., & Mauch, P. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.08.021 · Cited by 420 · see citing works
Eschenhagen, T., Force, T. L., Ewer, M. S., Keulenaer, G. W. D., Suter, T. M., Anker, S. D., Avkiran, M., de Azambuja, E., Balligand, J., Brutsaert, D. L., et al. (2010) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfq213 · Cited by 410 · see citing works
Self-citationSchultz-Hector, S., & Trott, K.-R. (2006) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2006.08.071 · Cited by 399 · see citing works
Harris, E. E. R., Correa, C. R., Hwang, W., Liao, J., Litt, H. I., Ferrari, V. A., & Solin, L. J. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.05.1037 · Cited by 396 · see citing works
Castellino, S. M., Geiger, A. M., Mertens, A. C., Leisenring, W. M., Tooze, J. A., Goodman, P., Stovall, M. A., Robison, L. L., & Hudson, M. M. (2010) · Blood · doi:10.1182/blood-2010-04-278796 · Cited by 366 · see citing works
Højris, I., Overgaard, M., Christensen, J. J., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(99)02245-x · Cited by 351 · see citing works
Long-Term Risk of Cardiovascular Disease in 5-Year Survivors of Testicular Cancer
van den Belt‐Dusebout, A. W., Nuver, J., de Wit, R., Gietema, J. A., Huinink, W. W. T. B., Rodrigus, P. T. R., Schimmel, E. C., Aleman, B. M. P., & van Leeuwen, F. E. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.02.7193 · Cited by 344 · see citing works
Self-citationLipshultz, S. E., Miller, T. L., Scully, R. E., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2010.30.3404 · Cited by 323 · see citing works
Myocardial injury revealed by plasma troponin I in breast cancer treated with high-dose chemotherapy
Cardinale, D. M., Sandri, M. T., Martinoni, A., Borghini, E., Civelli, M., Lamantia, G., Cinieri, S., Martinelli, G., Fiorentini, C., & Cipolla, C. M. (2002) · Annals of Oncology · doi:10.1093/annonc/mdf170 · Cited by 313 · see citing works
Anthracycline-induced cardiotoxicity: course, pathophysiology, prevention and management
Barry, E. V., Alvarez, J. A., Scully, R. E., Miller, T. L., & Lipshultz, S. E. (2007) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.8.8.1039 · Cited by 306 · see citing works
Patt, D. A., & Giordano, S. H. (2007) · Breast Diseases A Year Book Quarterly · doi:10.1016/s1043-321x(07)80352-3 · Cited by 305 · see citing works
Screening for Coronary Artery Disease After Mediastinal Irradiation for Hodgkin's Disease
Heidenreich, P. A., Schnittger, I., Strausś, H. W., Vagelos, R. H., Lee, B. K., Mariscal, C. S., Tate, D. J., Horning, S. J., Hoppe, R. T., & Hancock, S. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.07.0805 · Cited by 260 · see citing works
Galper, S. L., Yu, J. B., Mauch, P., et al. (2010) · Blood · doi:10.1182/blood-2010-06-291328 · Cited by 254 · see citing works
Rutqvist, L. E., & Johansson, H. (1990) · British Journal of Cancer · doi:10.1038/bjc.1990.193 · Cited by 253 · see citing works
Ewer, M. S., Ali, M. K., Mackay, B., Wallace, S., Valdivieso, M., Legha, S., Benjamin, R. S., & Haynie, T. P. (1984) · Journal of Clinical Oncology · doi:10.1200/jco.1984.2.2.112 · Cited by 244 · see citing works
Darby, S., McGale, P., Peto, R., Granath, F., Hall, P., & Ekbom, A. (2003) · BMJ · doi:10.1136/bmj.326.7383.256 · Cited by 235 · see citing works
Self-citationThe metabolic syndrome in cancer survivors
de Haas, E. C., Oosting, S. F., Lefrandt, J. D., Wolffenbuttel, B. H. R., Sleijfer, D. T., & Gietema, J. A. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70287-6 · Cited by 234 · see citing works
de Azambuja, E., Procter, M. J., van Veldhuisen, D. J., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.53.9288 · Cited by 234 · see citing works
Paszat, L. F., Mackillop, W. J., Groome, P. A., Schulze, K. M., & Holowaty, E. J. (1999) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(98)00412-x · Cited by 231 · see citing works
Cardiac Morbidity of Adjuvant Radiotherapy for Breast Cancer
Patt, D. A., Goodwin, J. S., Kuo, Y., Freeman, J. L., Zhang, D. D., Buchholz, T. A., Hortobágyi, G. N., & Giordano, S. H. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.13.755 · Cited by 225 · see citing works
Tassan‐Mangina, S., CODOREAN, D., Métivier, M., COSTA, B., Himberlin, C., Jouannaud, C., BLAISE, A., Elaerts, J., & Nazeyrollas, P. (2005) · European Journal of Echocardiography · doi:10.1016/j.euje.2005.04.009 · Cited by 212 · see citing works
Nottage, K. A., Ness, K. K., Li, C., Srivastava, D. K., Robison, L. L., & Hudson, M. M. (2014) · British Journal of Haematology · doi:10.1111/bjh.12754 · Cited by 209 · see citing works
Cause-specific mortality in long-term survivors of breast cancer: A 25-year follow-up study
Hooning, M. J., Aleman, B. M. P., van Rosmalen, A. J. M., Kuenen, M. A., Klijn, J. G. M., & van Leeuwen, F. E. (2006) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2005.10.022 · Cited by 207 · see citing works
Self-citationHerceptin and the Heart — A Molecular Modifier of Cardiac Failure
Chien, K. R. (2006) · New England Journal of Medicine · doi:10.1056/nejmp058315 · Cited by 201 · see citing works
Hodgkin's disease: Complications of therapy and excess mortality
Hoppe, R. T. (1997) · Annals of Oncology · doi:10.1093/annonc/8.suppl_1.s115 · Cited by 196 · see citing works
Coronary heart disease after radiotherapy for peptic ulcer disease
Carr, Z. A., Land, C. E., Kleinerman, R. A., Weinstock, R. M., Stovall, M. A., Griem, M. L., & Mabuchi, K. (2005) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2004.07.708 · Cited by 194 · see citing works
Nuver, J., Smit, A. J., Wolffenbuttel, B. H. R., Sluiter, W. J., Hoekstra, H. J., Sleijfer, D. T., & Gietema, J. A. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.02.176 · Cited by 194 · see citing works
Self-citationLifestyle Factors in Cancer Survivorship
Ligibel, J. A. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2012.42.0638 · Cited by 183 · see citing works
Roychoudhuri, R., Robinson, D., Putcha, V., Cuzick, J. M., Darby, S. C., & Møller, H. (2007) · BMC Cancer · doi:10.1186/1471-2407-7-9 · Cited by 178 · see citing works
Self-citationMyrehaug, S. D., Pintilie, M., Tsang, R. W. C., Mackenzie, R., Crump, M., Chen, Z., Sun, A. Y., & Hodgson, D. C. (2008) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190802140873 · Cited by 167 · see citing works
Role of Biomarkers in Chemotherapy-Induced Cardiotoxicity
Cardinale, D. M., & Sandri, M. T. (2010) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2010.04.002 · Cited by 167 · see citing works
Survivorship care planning after the Institute of Medicine recommendations: how are we faring?
Stricker, C. T., Jacobs, L. A., Risendal, B., Jones, A., Panzer, S., Ganz, P. A., Syrjala, K. L., McCabe, M. S., Baker, K. S., Miller, K. D., et al. (2011) · Journal of Cancer Survivorship · doi:10.1007/s11764-011-0196-4 · Cited by 166 · see citing works
Nuver, J., Smit, A. J., Wolffenbuttel, B. H. R., Sluiter, W. J., Hoekstra, H. J., Sleijfer, D. T., & Gietema, J. A. (2006) · The Journal of Urology · doi:10.1016/s0022-5347(05)01043-8 · Cited by 163 · see citing works
Self-citationVallis, K. A., Pintilie, M., Chong, N., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.4.1036 · Cited by 156 · see citing works
Maraldo, M. V., Brodin, N. P., Aznar, M. C., et al. (2013) · Annals of Oncology · doi:10.1093/annonc/mdt156 · Cited by 141 · see citing works
Self-citationDaugaard, G., Lassen, U., Bie, P., et al. (2004) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2004.03.009 · Cited by 139 · see citing works
Use of Survivorship Care Plans in the United States: Associations With Survivorship Care
Forsythe, L. P., Parry, C., Alfano, C. M., Kent, E. E., Leach, C. R., Haggstrom, D. A., Ganz, P. A., Aziz, N., & Rowland, J. H. (2013) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djt258 · Cited by 117 · see citing works
Care of the Cancer Survivor: Metabolic Syndrome after Hormone-Modifying Therapy
Redig, A. J., & Munshi, H. G. (2009) · The American Journal of Medicine · doi:10.1016/j.amjmed.2009.06.022 · Cited by 116 · see citing works
Early development of the metabolic syndrome after chemotherapy for testicular cancer
de Haas, E. C., Altena, R., Boezen, H. M., Zwart, N. R. K., Smit, A. J., Bakker, S. J. L., van Roon, A. M., Postma, A., Wolffenbuttel, B. H. R., Hoekstra, H. J., et al. (2012) · Annals of Oncology · doi:10.1093/annonc/mds527 · Cited by 113 · see citing works
Late Effects in the Era of Modern Therapy for Hodgkin Lymphoma
Hodgson, D. C. (2011) · Hematology · doi:10.1182/asheducation-2011.1.323 · Cited by 110 · see citing works
Cardiac toxicity with anti-HER-2 therapies-what have we learned so far?
de Azambuja, E., Bedard, P. L., Suter, T. M., & Piccart, M. J. (2009) · Targeted Oncology · doi:10.1007/s11523-009-0112-2 · Cited by 108 · see citing works
Self-citationRutqvist, L. E., Liedberg, A., Hammar, N., & Dalberg, K. (1998) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(97)00765-7 · Cited by 102 · see citing works
Long-Term Complications of Lymphoma and Its Treatment
Ng, A. K., LaCasce, A. S., & Travis, L. B. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.32.8427 · Cited by 100 · see citing works
Maraldo, M. V., Brodin, N. P., Vogelius, I. R., Aznar, M. C., af Rosenschöld, P. M., Petersen, R. H., & Specht, L. (2012) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2011.09.020 · Cited by 99 · see citing works
Self-citationD’Errico, M. P., Grimaldi, L., Petruzzelli, M. F., et al. (2011) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2011.03.058 · Cited by 96 · see citing works
Vallis, K. A. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.20.4.1036 · Cited by 86 · see citing works
State of the art in the treatment of Hodgkin lymphoma
Borchmann, P., Eichenauer, D. A., & Engert, A. (2012) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2012.91 · Cited by 83 · see citing works
B‐type natriuretic peptide as a marker for cardiac dysfunction in anthracycline‐treated children
Aggarwal, S. A., Pettersen, M. D., Bhambhani, K. J., et al. (2006) · Pediatric Blood & Cancer · doi:10.1002/pbc.21100 · Cited by 77 · see citing works
Collier, A., Ghosh, S. K., McGlynn, B., & Hollins, G. W. (2011) · American Journal of Clinical Oncology · doi:10.1097/coc.0b013e318201a406 · Cited by 73 · see citing works
Impact of internet‐based cancer survivorship care plans on health care and lifestyle behaviors
Hill‐Kayser, C. E., Vachani, C. C., Hampshire, M. K., Lullo, G. D., Jacobs, L. A., & Metz, J. M. (2013) · Cancer · doi:10.1002/cncr.28286 · Cited by 55 · see citing works
Bryant, J., Picot, J., Baxter, L. C., et al. (2007) · European Journal of Cancer · doi:10.1016/j.ejca.2007.06.012 · Cited by 54 · see citing works
The Metabolic Syndrome in Adult Survivors of Childhood Cancer, a Review
van Waas, M., Neggers, S. J. C. M. M., van der Lelij, A., Pieters, R., & van den Heuvel‐Eibrink, M. M. (2010) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0b013e3181d419c3 · Cited by 53 · see citing works
Underestimating Cardiac Toxicity in Cancer Trials: Lessons Learned?
Witteles, R. M., & Telli, M. L. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.40.4012 · Cited by 50 · see citing works
Cardiovascular complications of conventional and targeted adjuvant breast cancer therapy
Harbeck, N., Ewer, M. S., Laurentiis, M. D., et al. (2010) · Annals of Oncology · doi:10.1093/annonc/mdq543 · Cited by 41 · see citing works
Brodin, N. P., Maraldo, M. V., Aznar, M. C., Vogelius, I. R., Petersen, P. M., Bentzen, S. M., & Specht, L. (2013) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2013.10.028 · Cited by 38 · see citing works
Self-citationNewby, L. K., Rodríguez, I., Finkle, J. K., et al. (2011) · American Heart Journal · doi:10.1016/j.ahj.2011.04.005 · Cited by 36 · see citing works
McGale, P., & Darby, S. C. (2008) · International Journal of Epidemiology · doi:10.1093/ije/dyn067 · Cited by 35 · see citing works
Self-citationHilbers, F., Boekel, N. B., van den Broek, A. J., van Hien, R., Cornelissen, S., Aleman, B. M. P., Veer, L. V. ‘., van Leeuwen, F. E., & Schmidt, M. K. (2011) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2011.10.017 · Cited by 28 · see citing works
Self-citationCardiovascular Safety Monitoring During Oncology Drug Development and Therapy
Turner, J. R., Panicker, G. K., Karnad, D. R., Cabell, C. H., Lieberman, R., & Kothari, S. (2014) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000000027 · Cited by 13 · see citing works
Cardiac function in survivors of acute lymphoblastic leukaemia and Hodgkin's lymphoma
Krawczuk‐Rybak, M., Dakowicz, Ł., Hryniewicz, A., et al. (2011) · Journal of Paediatrics and Child Health · doi:10.1111/j.1440-1754.2010.01991.x · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Freisling, H., Viallon, V., Lennon, H., Bagnardi, V., Ricci, C., Butterworth, A. S., Sweeting, M., Muller, D., Romieu, I., Bazelle, P., et al. (2020) · BMC Medicine · doi:10.1186/s12916-019-1474-7 · Cited by 376 · see citing works
Ormel, H. L., van der Schoot, G. G. F., Sluiter, W. J., Jalving, M., Gietema, J. A., & Walenkamp, A. M. E. (2018) · Psycho-Oncology · doi:10.1002/pon.4612 · Cited by 261 · see citing works
Heart in space: effect of the extraterrestrial environment on the cardiovascular system
Hughson, R. L., Helm, A., & Durante, M. (2018) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.157 · Cited by 257 · see citing works
Insights into US life expectancy stagnation from birth cohort mortality dynamics
Abrams, L., Bramajo, O., van Raalte, A., Myrskylä, M., & Mehta, N. K. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2519356123 · Cited by 6 · see citing works
“Conditions and their treatment can interact with each other; for example, cancer treatments and drug abuse affect cardiovascular health (19–22).”
- Authors
- Aleman, B. M. P., Moser, E. C., Nuver, J., Suter, T. M., Maraldo, M. V., Specht, L., Vrieling, C., & Darby, S. C.
- Affiliations
- The Netherlands Cancer Institute (NL)
- Champalimaud Foundation (PT)
- University Medical Center Groningen (NL)
- University Hospital of Bern (CH)
- University of Copenhagen (DK)
- University of Oxford (GB)
- Corresponding author
- Aleman, Berthe M.P.
- ORCID
- Venue
- European Journal of Cancer Supplements
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 12
- Issue
- 1
- Pages
- 18-28
- ISSN
- 1359-6349 (ISSN-L)
- PMC
- PMC4250533
- OpenAlex
- W2007078396
- Cited by
- 168
- References
- 101
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 8 · 2023: 21 · 2022: 17 · 2021: 9 · 2020: 16 · 2019: 16 · 2018: 17 · 2017: 18 · 2016: 14 · 2015: 2
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- European Journal of Cancer Supplements (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by-nc-nd)
- Funders
- Cancer Research UK (16896)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Chemotherapy-induced cardiotoxicity and mitigation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac tumors and thrombi
- Health Sciences › Medicine › Epidemiology › Multiple and Secondary Primary Cancers
- Keywords
- cardiovascular disease, cardiotoxicity, late effects of cancer treatment, cancer survivors, chemotherapy-induced cardiotoxicity, cardiovascular risk factors, cardiovascular screening, risk prediction model, surrogate markers, primary and secondary prevention
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
