Incident Atrial Fibrillation and Mortality in Older Adults with Heart Failure
Abstract
We studied 944 hospitalized heart failure patients 65 years and older to examine the impact of incident atrial fibrillation on mortality. Patients were categorized into four groups based on past medical history and admission electrocardiogram: (1) no (neither past nor current), (2) incident (newly diagnosed), (3) past and (4) chronic (past and current) atrial fibrillation. The primary outcome was 4-year all-cause mortality. Bivariate and multivariable Cox proportion hazards analyses were used to determine risk of all-cause mortality. In the multivariable model, we adjusted for various demographic and clinical covariates. Compared with patients who never had atrial fibrillation, those with incident atrial fibrillation had a 57% higher risk of death (unadjusted hazard ratio, 1.57; 95% confidence interval, 1.22–2.03). After adjustment for other covariates the association remained unchanged (adjusted hazard ratio, 1.41; 95% confidence interval, 1.08–1.83). Past or chronic atrial fibrillation was not associated with increased risk of death.
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New-onset atrial fibrillation in heart failure patients might be associated with a particularly poor prognosis.
“Moreover, new-onset AF in heart failure patients might be associated with a particularly poor prognosis.31, 32”
From Worldwide Epidemiology of Atrial Fibrillation: A Global Burden of Disease 2010 Study (2014) · cites this paper as [32]
Cites
Wang, T. J., Larson, M. G., Levy, D., Vasan, R. S., Leip, E. P., Wolf, P. A., D’Agostino, R. B., Murabito, J. M., Kannel, W. B., & Benjamin, E. J. (2003) · Circulation · doi:10.1161/01.cir.0000072767.89944.6e · Cited by 1,970 · cited 2× · see citing works
“reported that of the 382 patients (mean age about 74 years) who had both heart failure and atrial fibrillation, 159 had incident atrial fibrillation, 79 had atrial fibrillation at the time of the diagnosis of heart failure [2].”
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Ahmed, A., Thornton, P. L., Perry, G. J., Allman, R. M., & DeLong, J. F. (2004) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2003.11.011 · Cited by 60 · see citing works
Self-citationAge-Related Underutilization of Left Ventricular Function Evaluation in Older Heart Failure Patients
Ahmed, A., Allman, R. M., DeLong, J. F., et al. (2002) · Southern Medical Journal · doi:10.1097/00007611-200295070-00008 · Cited by 8 · see citing works
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Worldwide Epidemiology of Atrial Fibrillation: A Global Burden of Disease 2010 Study
Chugh, S. S., Havmoeller, R., Narayanan, K., Singh, D., Rienstra, M., Benjamin, E. J., Gillum, R. F., Kim, Y.-H., McAnulty, J. H., Zheng, Z.-J., et al. (2014) · Circulation · doi:10.1161/circulationaha.113.005119 · Cited by 4,506 · see citing works
Global epidemiology of atrial fibrillation
Rahman, F., Kwan, G. F., & Benjamin, E. J. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.118 · Cited by 731 · see citing works
- Authors
- Ahmed, A., & Perry, G. J.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Ahmed, Ali
- Venue
- European Journal of Heart Failure
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-12-01
- Volume
- 7
- Issue
- 7
- Pages
- 1118-1121
- ISSN
- 1388-9842 (ISSN-L)
- 1879-0844
- OpenAlex
- W2039276365
- Cited by
- 35
- References
- 9
- Citations by year
- 2025: 2 · 2024: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 4 · 2013: 4 · 2012: 2
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Heart Failure (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (1-K23-AG19211-01, K23AG019211)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- incident atrial fibrillation, heart failure, older adults, all-cause mortality, chronic atrial fibrillation, newly diagnosed atrial fibrillation, hospitalized patients, electrocardiogram, risk factors
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Alabama, Atrial Fibrillation, Electrocardiography, Female, Follow-Up Studies, Heart Failure, Humans, Male, Retrospective Studies, Risk Factors, Prevalence, Survival Rate
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