CoChat
Sign Up
Cited by 32Cardiac Fibrosis and RemodelingNitric Oxide and Endothelin EffectsCardiovascular Function and Risk Factors

Oxidative Remodeling in Pressure Overload Induced Chronic Heart Failure

Henderson, Brooke C., Tyagi, Neetu, Ovechkin, Alexander, Kartha, Ganesh K., Moshal, Karni S., Tyagi, Suresh C.·2007·European Journal of Heart Failure
DOI 10.1016/j.ejheart.2006.12.008
Open this paper in CoChat — free account

Abstract

Despite extensive strides in understanding pressure overload induced heart failure, there is very little known about oxidative stress induced matrix metalloproteinase (MMP) activation, collagen degradation and remodeling in pressure overload heart failure. We hypothesize that pressure overload leads to redox imbalance causing increased expression/activity of MMP-2/9 producing collagen degradation and heart failure. To test this hypothesis, we created pressure overload heart failure by abdominal aortic stenosis (AS) in wild-type C57BL/6J and collagen mutant (Col1a1 with 129 s background) mice. At 4 weeks, post surgery, functional parameters were measured. Left ventricle (LV) tissue sections were analyzed by histology, Western Blot and PCR. The results suggest an increase in iNOS with a decrease in eNOS, an increase in nitrated protein modification and depletion of antioxidants thioredoxin and SOD in pressure overload. MMP-2/9 expression/activity and collagen degradation were increased in the AS animals. To determine whether a mutation in the collagen gene at the site of MMP cleavage mitigates cardiac hypertrophy, we used Col1a1 mice. In these mice, the AS induced LV hypertrophy (LVH) was ameliorated. In conclusion, our results suggest that AS leads to increased oxidative stress, expression/activity of MMP-2/9 and a decrease in antioxidant expression producing collagen degradation and heart failure.

Integrity signals

Registry

Crossref · 10.1016/j.ejheart.2006.12.008

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In a pressure-overload model of heart failure in mice, increased collagen degradation as a result of elevated expression and activity of MMP-2/9 correlated with development of heart failure.

    “Furthermore, in a pressure-overload model of heart failure in mice, an increased collagen degradation as a result of elevated expression and activity of MMP-2/9 correlated with development of heart failure (135).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [135]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Henderson, B. C., Tyagi, N., Ovechkin, A., Kartha, G. K., Moshal, K. S., & Tyagi, S. C.
Affiliations
University of Louisville (US)
Corresponding author
Henderson, Brooke C.
ORCID
Venue
European Journal of Heart Failure
Publisher
Oxford University Press (OUP)
Published
2007-04-15
Volume
9
Issue
5
Pages
450-457
ISSN
  • 1388-9842 (ISSN-L)
  • 1879-0844
DOI
10.1016/j.ejheart.2006.12.008
OpenAlex
W2064525822
Cited by
32
References
27
Citations by year
2026: 2 · 2023: 1 · 2022: 2 · 2021: 3 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 3 · 2014: 1 · 2013: 2 · 2012: 2
FWCI
2.10
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • European Journal of Heart Failure (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (R01HL074185, HL 74185)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
pressure overload, chronic heart failure, oxidative stress, MMP-2, MMP-9, collagen degradation, cardiac remodeling, abdominal aortic stenosis, left ventricular hypertrophy, nitric oxide synthase, nitrated proteins, thioredoxin, superoxide dismutase, redox imbalance
MeSH terms
Analysis of Variance, Animals, Aortic Valve Stenosis, Blood Pressure, Chronic Disease, Collagen, Disease Models, Animal, Echocardiography, Elastin, Electrocardiography, Enzyme Activation, Heart Failure, Male, Mice, Inbred C57BL, Mice, Mutant Strains, Research Design, Stroke Volume, Blotting, Western, Hypertrophy, Left Ventricular, Oxidative Stress, Ventricular Dysfunction, Left, Reverse Transcriptase Polymerase Chain Reaction, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Mice, Nitric Oxide Synthase Type II, Nitric Oxide Synthase Type III

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review