Endothelial function parameters in patients with unstable angina and infection with Helicobacter pylori and Chlamydia pneumoniae
Abstract
Background Endothelial dysfunction may be a factor linking infection with atherosclerosis. The aim of our study was to assess the relationship between seropositivity to Helicobacter pylori (Hp) and/or to Chlamydia pneumoniae (Cp) and some endothelial function parameters in patients with unstable angina.Methods In 31 patients with unstable angina, we determined the serum concentration of the von Willebrand factor (vWF), thrombomodulin, tissue plasminogen activator antigen, and tissue plasminogen activator inhibitor type 1 antigen, the concentration of IgG antibodies to Hp and Cp (all by ELISA), and the level of C-reactive protein. The Western blot test was performed for all patients seropositive to Hp. It allowed us to identify 15 different antigen proteins of Hp.Results Sixty-one percent of the patients were seropositive to both Hp and Cp, and 35% were seropositive to Hp only. We did not find significant differences in serum concentrations of endothelial function parameters and CRP between the two groups of patients. The patients seropositive to both Hp and Cp had a significantly higher serum concentration of vWF when Hp did not contain the 95 kDa protein (p=0.01) and a significantly higher serum concentration of PAI-1:Ag when Hp did not contain the 57 kDa protein (p=0.002) and the 66 kDa protein (p=0.02).Conclusion The results show that the antigenic profile of bacteria may play a more significant role in coronary artery disease than seropositivity.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Helicobacter pylori is linked to peptic ulcer disease, gastric cancer, as well as diabetes, autoimmune disease, chronic inflammation, CVD and endothelial dysfunction.
“Epidemiologically, H. pylori is linked to peptic ulcer disease, gastric cancer, as well as diabetes, autoimmune disease, chronic inflammation, CVD and endothelial dysfunction[240–245].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [245]
Cites
Saikku, P., Mattila, K. J., Nieminen, M. S., Huttunen, J. K., Leinonen, M., Ekman, M.-R., Mäkelä, P. H., & Valtonen, V. (1988) · The Lancet · doi:10.1016/s0140-6736(88)90741-6 · Cited by 1,961 · see citing works
Relation of Helicobacter pylori infection and coronary heart disease.
Mendall, M. A., Goggin, P. M., Molineaux, N., Levy, J., Toosy, T., Strachan, D. P., Camm, A. J., & Northfield, T. C. (1994) · Heart · doi:10.1136/hrt.71.5.437 · Cited by 657 · see citing works
Epstein, S. E., Zhou, Y., & Zhu, J. (1999) · Circulation · doi:10.1161/01.cir.100.4.e20 · Cited by 512 · see citing works
Zhou, Y. F., Leon, M. B., Waclawiw, M. A., Popma, J. J., Yu, Z., Finkel, T., & Epstein, S. E. (1996) · New England Journal of Medicine · doi:10.1056/nejm199608293350903 · Cited by 450 · see citing works
Muhlestein, J. B., Hammond, E. H., Carlquist, J. F., Radicke, E., Thomson, M. J., Karagounis, L. A., Woods, M. L., & Anderson, J. L. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(96)00055-1 · Cited by 420 · see citing works
Impact of Infectious Burden on Extent and Long-Term Prognosis of Atherosclerosis
Espinola–Klein, C., Rupprecht, H. J., Blankenberg, S., Bickel, C., Kopp, H., Rippin, G., Victor, A., Hafner, G., Schlumberger, W., & Meyer, J. (2002) · Circulation · doi:10.1161/hc0102.101362 · Cited by 338 · see citing works
Effects of total pathogen burden on coronary artery disease risk and C-reactive protein levels
Zhu, J., Quyyumi, A. A., Norman, J. E., Csákó, G., Waclawiw, M. A., Shearer, G. M., & Epstein, S. E. (2000) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00653-0 · Cited by 298 · see citing works
Prospective Study of Pathogen Burden and Risk of Myocardial Infarction or Death
Zhu, J., Nieto, F. J., Horne, B. D., Anderson, J. L., Muhlestein, J. B., & Epstein, S. E. (2001) · Circulation · doi:10.1161/01.cir.103.1.45 · Cited by 279 · see citing works
Rupprecht, H. J., Blankenberg, S., Bickel, C., et al. (2001) · Circulation · doi:10.1161/hc2601.091703 · Cited by 255 · see citing works
Stone, A., Mendall, M. A., Kaski, J. C., Edger, T. M., Risley, P., Poloniecki, J. D., Camm, A. J., & Northfield, T. C. (2002) · Circulation · doi:10.1161/01.cir.0000027820.66786.cf · Cited by 199 · see citing works
Birnie, D. H. (1998) · European Heart Journal · doi:10.1053/euhj.1997.0618 · Cited by 163 · see citing works
Cytomegalovirus/herpesvirus and carotid atherosclerosis: The aric study
Sorlie, P. D., Adam, E., Melnick, S. L., et al. (1994) · Journal of Medical Virology · doi:10.1002/jmv.1890420107 · Cited by 136 · see citing works
Haemostatic risk factors for cardiovascular diseases.
Köenig, W. (1998) · PubMed · Cited by 111 · see citing works
Espinola–Klein, C., Rupprecht, H., Blankenberg, S., Bickel, C., Kopp, H., Rippin, G., Hafner, G., Pfeifer, U., & Meyer, J. (2000) · Stroke · doi:10.1161/01.str.31.9.2127 · Cited by 100 · see citing works
Parchure, N., Zouridakis, E., & Kaski, J. C. (2002) · Circulation · doi:10.1161/hc1102.105649 · Cited by 79 · see citing works
Ezzahiri, R., Nelissen-Vrancken, H. J. M. G., Kurvers, H. A. J. M., Stassen, F. R. M., Vliegen, I., Grauls, G., VANPUL, M., Kitslaar, P. J. E. H. M., & Bruggeman, C. A. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00544-8 · Cited by 62 · see citing works
Smiseth, O. A., Thompson, C., Ling, H., et al. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00420-3 · Cited by 37 · see citing works
Grąbczewska, Z., Nartowicz, E., Szymaniak, L., et al. (2002) · PubMed · Cited by 6 · see citing works
Self-citationvan der Wal, A. C. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00652-1 · Cited by 5 · see citing works
Grąbczewska, Z., Nartowicz, E., Szymaniak, L., et al. (2002) · PubMed · Cited by 1 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Koch, C. D., Gladwin, M. T., Freeman, B. A., Lundberg, J. O., Weitzberg, E., & Morris, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.015 · Cited by 186 · see citing works
- Authors
- Grąbczewska, Z., Nartowicz, E., Kubica, J., & Rość, D.
- Affiliations
- Nicolaus Copernicus University (PL)
- Corresponding author
- Grąbczewska, Zofia
- Venue
- European Journal of Internal Medicine
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 17
- Issue
- 5
- Pages
- 339-342
- ISSN
- 0953-6205 (ISSN-L)
- OpenAlex
- W2006757729
- Cited by
- 20
- References
- 20
- Citations by year
- 2026: 1 · 2022: 1 · 2016: 3 · 2015: 3 · 2012: 1
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- endothelial dysfunction, unstable angina, Helicobacter pylori, Chlamydia pneumoniae, bacterial infection, von Willebrand factor, thrombomodulin, tissue plasminogen activator, C-reactive protein, bacterial antigens, coronary artery disease, atherosclerosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
