Cited by 65Pancreatitis Pathology and TreatmentGallbladder and Bile Duct DisordersLipid metabolism and disorders

Plasmapheresis as treatment for hyperlipidemic pancreatitis

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Ramírez-Bueno, A., Salazar-Ramírez, C., Cota-Delgado, F., de la Torre-Prados, M.V., Valdivielso, P.·2014·European Journal of Internal Medicine

Abstract

Background Severe hypertriglyceridemia with an accumulation of chylomicrons and triglyceride figures >1000 mg/dL can cause acute pancreatitis, a potentially fatal complication. The option of rapid reduction in triglyceride concentrations is attractive and possible with plasmapheresis.Methods We present the results of an analysis of 11 patients admitted to the intensive care unit with severe hypertriglyceridemic pancreatitis and treated with plasmapheresis. The procedure was repeated until serum triglycerides were below 1000 mg/dL. We recorded anthropometric, clinical data as well as final outcome.Results In eight patients a single plasma exchange was sufficient to reduce triglyceride figures <1000 mg/dL. Only three patients died, all with the worst severity indexes and who experienced the longest delay before the procedure.Conclusions Our results, together with a review of the literature, confirm the need for a randomized clinical trial to compare conventional treatment vs. plasmapheresis in patients with severe hypertriglyceridemic pancreatitis.

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Crossref · 10.1016/j.ejim.2013.08.701

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  • Plasmapheresis acutely decreases TG levels by 50-80% and may theoretically eliminate the causal factor in HTG-induced pancreatitis.

    “Plasmapheresis acutely decreases TG levels by 50–80% and may thus theoretically eliminate the causal factor in HTG-induced pancreatitis.26,56”

    From Clinical review on triglycerides (2020) · cites this paper as [56]

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Authors
Ramírez-Bueno, A., Salazar-Ramírez, C., Cota-Delgado, F., de la Torre-Prados, M. V., & Valdivielso, P.
Affiliations
Hospital Clínico Universitario Virgen de la Victoria (ES)
Corresponding author
Valdivielso, P.
Venue
European Journal of Internal Medicine
Publisher
Elsevier BV
Published
2014-02
Volume
25
Issue
2
Pages
160-163
ISSN
0953-6205 (ISSN-L)
OpenAlex
W2079045033
Cited by
65
References
41
Citations by year
2025: 5 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 8 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 7 · 2013: 1
FWCI
5.25
Type
journal article
Language
en
Open access
Locations
  • European Journal of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • RISalud Institutional Health Repository of Andalucía (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gallbladder and Bile Duct Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords
plasmapheresis, hypertriglyceridemia-induced pancreatitis, acute pancreatitis, hypertriglyceridemia, triglyceride lowering, chylomicrons, intensive care, mortality, treatment outcomes
MeSH terms
Adult, Alcohol Drinking, Female, Humans, Male, Middle Aged, Pancreatitis, Plasmapheresis, Retrospective Studies, Severity of Illness Index, Hypertriglyceridemia, Cohort Studies, Treatment Outcome

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