Plasmapheresis as treatment for hyperlipidemic pancreatitis
Open accessAbstract
Background Severe hypertriglyceridemia with an accumulation of chylomicrons and triglyceride figures >1000 mg/dL can cause acute pancreatitis, a potentially fatal complication. The option of rapid reduction in triglyceride concentrations is attractive and possible with plasmapheresis.Methods We present the results of an analysis of 11 patients admitted to the intensive care unit with severe hypertriglyceridemic pancreatitis and treated with plasmapheresis. The procedure was repeated until serum triglycerides were below 1000 mg/dL. We recorded anthropometric, clinical data as well as final outcome.Results In eight patients a single plasma exchange was sufficient to reduce triglyceride figures <1000 mg/dL. Only three patients died, all with the worst severity indexes and who experienced the longest delay before the procedure.Conclusions Our results, together with a review of the literature, confirm the need for a randomized clinical trial to compare conventional treatment vs. plasmapheresis in patients with severe hypertriglyceridemic pancreatitis.
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Plasmapheresis acutely decreases TG levels by 50-80% and may theoretically eliminate the causal factor in HTG-induced pancreatitis.
“Plasmapheresis acutely decreases TG levels by 50–80% and may thus theoretically eliminate the causal factor in HTG-induced pancreatitis.26,56”
From Clinical review on triglycerides (2020) · cites this paper as [56]
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Therapeutic Plasma‐albumin Exchange for Hyperlipidemia Induced Acute Pancreatitis
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Research Progress on the Treatment of Hypertriglyceridemic Acute Pancreatitis
何, 浩. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.15113107
- Authors
- Ramírez-Bueno, A., Salazar-Ramírez, C., Cota-Delgado, F., de la Torre-Prados, M. V., & Valdivielso, P.
- Affiliations
- Hospital Clínico Universitario Virgen de la Victoria (ES)
- Corresponding author
- Valdivielso, P.
- Venue
- European Journal of Internal Medicine
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 25
- Issue
- 2
- Pages
- 160-163
- ISSN
- 0953-6205 (ISSN-L)
- OpenAlex
- W2079045033
- Cited by
- 65
- References
- 41
- Citations by year
- 2025: 5 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 8 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 7 · 2013: 1
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- European Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- RISalud Institutional Health Repository of Andalucía (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gallbladder and Bile Duct Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- plasmapheresis, hypertriglyceridemia-induced pancreatitis, acute pancreatitis, hypertriglyceridemia, triglyceride lowering, chylomicrons, intensive care, mortality, treatment outcomes
- MeSH terms
- Adult, Alcohol Drinking, Female, Humans, Male, Middle Aged, Pancreatitis, Plasmapheresis, Retrospective Studies, Severity of Illness Index, Hypertriglyceridemia, Cohort Studies, Treatment Outcome
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