Cited by 54Synthesis and biological activitySteroid Chemistry and BiochemistryPhytochemical Studies and Bioactivities

Synthesis and antineoplastic activity of 2-alkylaminoethyl derivatives of various steroidal oximes

Jindal, Dharam Paul, Chattopadhaya, Raja, Guleria, Sheetal, Gupta, Ranju·2003·European Journal of Medicinal Chemistry

Abstract

Various steroidal oxime ether derivatives in androstene and estrane series have been synthesized and evaluated for the antineoplastic activity at National Cancer Institute, Bethesda, Maryland, USA. O-alkylation of the oximes by various alkylaminoethyl halides gave the oxime ether derivatives. The 17alpha-ethynylandrostene derivatives 29 (DPJ-684), 30 (DPJ-685), 31 (DPJ-686) and estrane derivatives 35 (DPJ-531) and 36 (DPJ-532) were among the small percentage of compounds, which have been screened by NCI for in vivo hollow fiber assay by virtue of their activity against one or more human tumour cell lines in 60 cell line in vitro prescreen. The preliminary in vivo reports of hollow fiber assays have been referred to the Biological Evaluation Committee for Cancer Drugs for considering these compounds for further detailed in vivo testing.

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Crossref · 10.1016/j.ejmech.2003.09.002

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Authors
Jindal, D. P., Chattopadhaya, R., Guleria, S., & Gupta, R.
Affiliations
Panjab University (IN)
Corresponding author
Gupta, Ranju
Venue
European Journal of Medicinal Chemistry
Publisher
Elsevier BV
Published
2003-11
Volume
38
Issue
11-12
Pages
1025-1034
ISSN
0223-5234 (ISSN-L)
OpenAlex
W1967693558
Cited by
52
References
22
Citations by year
2025: 2 · 2023: 5 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 6 · 2014: 4 · 2013: 3 · 2012: 1
FWCI
0.94
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Medicinal Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Council of Scientific and Industrial Research, India
  • National Cancer Institute
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
Keywords
oxime ethers, anticancer activity, O-alkylation, estrane derivatives, hollow fiber assay, human cancer cell lines, anticancer drug candidates
MeSH terms
Antineoplastic Agents, Humans, Oximes, Antineoplastic Agents, Alkylating, Cell Line, Tumor

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