Cited by 58Protein Tyrosine PhosphatasesSynthesis and biological activityNatural Antidiabetic Agents Studies

Novel 2-aryl-naphtho[1,2-d]oxazole derivatives as potential PTP-1B inhibitors showing antihyperglycemic activities

Kumar, Atul, Ahmad, Pervez, Maurya, Ram Awatar, Singh, A.B., Srivastava, Arvind K.·2009·European Journal of Medicinal Chemistry

Abstract

A series of 2-aryl-naphtho[1,2-d]oxazole derivatives have been synthesized and evaluated for PTP-1B inhibitory activity. The compounds have been screened in vivo for antidiabetic activity under sucrose loaded model (SLM), sucrose-challenged streptozotocin-induced diabetic rat model (STZ-S) and db/db mice model. Compounds 8 and 12 have shown promising PTP-1B inhibitory activity, significant antidiabetic activity, moderate lipid and triglyceride lowering activity.

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Crossref · 10.1016/j.ejmech.2008.03.009

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  • Using adaptive emotion regulation strategies such as cognitive reappraisal can increase positive emotions and reduce negative emotions in stress, anxiety, depression, and mood swings.

    “ّن چٌیي، اؾتفازُ اظ تطذی ضاّثطزّای ؾاظگاضاًِ تٌؾین ّیزاى ّوچَى اضظیاتی هزسز قٌاذتی زض هَارِْ تا اؾتطؼ، اضغطاب، افؿطزگی ٍ ًَؾاًات ذلمی زض تؿیاضی اظ هَالـ فلاٍُ تط واؾتي اظ ّیزاًات هٌفی، هیتَاًس ّیزاًات هخثت ضا افعایف زّس 43( ، )44 .”

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Authors
Kumar, A., Ahmad, P., Maurya, R. A., Singh, A. B., & Srivastava, A. K.
Affiliations
Central Drug Research Institute (IN)
Corresponding author
Kumar, Atul
Venue
European Journal of Medicinal Chemistry
Publisher
Elsevier BV
Published
2009-01
Volume
44
Issue
1
Pages
109-116
ISSN
0223-5234 (ISSN-L)
OpenAlex
W2952023935
Cited by
54
References
15
Citations by year
2025: 1 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 6 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 5
FWCI
1.78
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Medicinal Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
  • Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Keywords
PTP1B, antidiabetic activity, streptozotocin-induced diabetes, db/db mice, hypolipidemic activity, triglyceride lowering
MeSH terms
Animals, Diabetes Mellitus, Experimental, Enzyme Inhibitors, Hypoglycemic Agents, Lipids, Oxazoles, Structure-Activity Relationship, Triglycerides, Mice, Rats, Protein Tyrosine Phosphatase, Non-Receptor Type 1

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