New scaffolds of natural origin as Integrase–LEDGF/p75 interaction inhibitors: Virtual screening and activity assays

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Small-Molecule Inhibitors of the LEDGF/p75 Binding Site of Integrase Block HIV Replication and Modulate Integrase Multimerization

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Pharmacophore‐Based Discovery of Small‐Molecule Inhibitors of Protein–Protein Interactions between HIV‐1 Integrase and Cellular Cofactor LEDGF/p75

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Design of HIV-1 integrase inhibitors targeting the catalytic domain as well as its interaction with LEDGF/p75: A scaffold hopping approach using salicylate and catechol groups

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HIV-1 integrase inhibitors: 2007-2008 update

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Inhibitors of the Interactions between HIV‐1 IN and the Cofactor LEDGF/p75

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Cellular Cofactors of Lentiviral Integrase: From Target Validation to Drug Discovery

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Inhibition of the Interaction between HIV-1 Integrase and its Cofactor LEDGF/p75: A Promising Approach in Anti-Retroviral Therapy

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Identification of old drugs as potential inhibitors of HIV-1 integrase – human LEDGF/p75 interaction via molecular docking

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4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration process

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Insight into the Fundamental Interactions between LEDGF Binding Site Inhibitors and Integrase Combining Docking and Molecular Dynamics Simulations

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Prognostic Value of Virological and Immunological Responses After 6 Months of Antiretroviral Treatment in Adults With HIV-1 Infection in Sub-Saharan Africa

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Fragment hopping approach directed at design of HIV IN-LEDGF/p75 interaction inhibitors

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Microwave Assisted Organic Synthesis (MAOS) of Small Molecules as Potential HIV-1 Integrase Inhibitors

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Modulators of Protein–Protein Interactions

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Targeting Virus-host Interactions of HIV Replication

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Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase

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Rational Design, Synthesis and Evaluation of Coumarin Derivatives as Protein‐protein Interaction Inhibitors

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Virtual-screening targeting Human Immunodeficiency Virus type 1 integrase-lens epithelium-derived growth factor/p75 interaction for drug development

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Quantitative Structure-Activity Relationship Study for HIV-1 LEDGF/p75 Inhibitors

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Structural basis for the potent inhibition of the HIV integrase-LEDGF/p75 protein–protein interaction

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De Novo Design of HIV‐1 Integrase‐LEDGF/p75 Inhibitors Through Deep Reinforcement Learning and Virtual Screening

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BindingDB Entry 50047378: Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends.

BindingDB (2017) · UC San Diego · doi:10.7270/q2jh3p3h

BindingDB Entry 50006284: Optimization of rhodanine scaffold for the development of protein-protein interaction inhibitors.

BindingDB (2020) · UC San Diego · doi:10.7270/q2s75k94

BindingDB Entry 50006340: Synthesis of dihydropyrimidine α,γ-diketobutanoic acid derivatives targeting HIV integrase.

BindingDB (2020) · UC San Diego · doi:10.7270/q2cr5xb5

BindingDB Entry 50044218: A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition.

BindingDB (2015) · UC San Diego · doi:10.7270/q2902598

Inhibitors of HIV‐1 Integrase‐Human LEDGF/p75 Interaction Identified from Natural Products via Virtual Screening

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Cover Picture: Inhibitors of HIV‐1 Integrase‐Human LEDGF/p75 Interaction Identified from Natural Products via Virtual Screening (Chin. J. Chem. 12/2012)

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Discovery of Inhibitors To Block Interactions of HIV-1 Integrase with Human LEDGF/p75 via Structure-Based Virtual Screening and Bioassays

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Structure-based virtual screening toward the discovery of novel inhibitors for impeding the protein-protein interaction between HIV-1 integrase and human lens epithelium-derived growth factor (LEDGF/p75)

Panwar, U., & Singh, S. K. (2017) · Figshare · doi:10.6084/m9.figshare.5527858

Virtual-screening targeting Human Immunodeficiency Virus type 1 integrase-lens epithelium-derived growth factor/p75 interaction for drug development

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