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Cited by 220

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Integration of endocrine and mechanical signals in the regulation of myometrial functions during pregnancy and labour

Shynlova, Oksana, Tsui, Prudence, Jaffer, Shabana, Lye, Stephen J.·2009·European Journal of Obstetrics & Gynecology and Reproductive Biology
DOI 10.1016/j.ejogrb.2009.02.044
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Abstract

In this review, we describe a new model to explain the regulation of myometrial function during pregnancy and labour. We propose that the myometrium undergoes dramatic changes in phenotype from early pregnancy until the onset of labour, characterized by an early proliferative phase, an intermediate phase of cellular hypertrophy and matrix elaboration, a third phase in which the cells assume a contractile phenotype and the final phase in which cells become highly active and committed to labour. The last phase of myometrial differentiation is postpartum uterine involution, completing the reproductive cycle following pregnancy and labour by returning the uterus to its non-pregnant receptive state. We further propose that phenotypic modulation of the uterine myocytes is the result of integration of endocrine signals and mechanical stimulation of the uterus by the growing fetus. Our previous studies have shown that these signals are important in regulating the onset of labour and we now have indications that they regulate earlier myometrial smooth muscle differentiation. We show that the high rate of myometrial cell proliferation in early pregnancy which reflects important aspects of many smooth muscle populations during development. The proliferative phenotype was associated with dramatic changes in the expression of IGF family proteins and coincided with an up-regulation of the anti-apoptotic pathway. Preliminary evidence suggests that myometrial hyperplasia was controlled by th…

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Crossref · 10.1016/j.ejogrb.2009.02.044

Cites

46 of 46 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 46 references

Research works printed but not linked: 3

  1. Jaffer, 2008, The role of the mTOR signalling pathway in myometrial differentiation, Suppl Reprod Sci, 15, 63A
  2. Jaffer SN, Shynlova O, Lye SJ. mTOR is a mediator of estrogen-induced myometrial proliferation during pregnancy. Endocrinology; under review.
  3. Reynolds SRM. Gestational mechanisms. Physiology of the Uterus, 2nd ed., 1949, pp. 218–234. New York: Hoeber. Ref Type: Generic.

Cited by

Metadata

Authors
Shynlova, O., Tsui, P., Jaffer, S., & Lye, S. J.
Venue
European Journal of Obstetrics & Gynecology and Reproductive Biology
Publisher
Elsevier BV
Published
2009-05
Volume
144
Pages
S2-S10
ISSN
0301-2115
DOI
10.1016/j.ejogrb.2009.02.044
Cited by
220
References
46
Language
en
Licence

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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