Hsa-mir-548 family expression in human reproductive tissues
Open accessAbstract
Background: Hsa-miR-548ba expressed in ovarian granulosa cells targets PTEN and LIFR, which are essential for ovarian follicle activation and growth. The expression pattern of hsa-miR-548ba correlates with its host gene follicle-stimulating hormone receptor (FSHR), and FSH has a positive influence on hsa-miR-548ba expression. However, hsa-miR-548ba is a member of a large hsa-mir-548 family with potentially overlapping targets. The current study aims to investigate the co-expression of hsa-mir-548 family members in FSHR-positive reproductive tissues and to explore the potential co-regulation of pathways. Results: For the above-described analysis, small RNA sequencing data from public data repositories were used. Sequencing results revealed that hsa-miR-548ba was expressed at the highest level in the ovarian granulosa cells and uterine myometrial samples together with another twelve and one hsa-miR-548 family members, respectively. Pathway enrichment analysis of microRNA targets in the ovarian samples revealed the hsa-miR-548ba and hsa-miR-548b-5p co-regulation of RAB geranylgeranylation in mural granulosa cells. Moreover, other hsa-mir-548 family members co-regulate pathways essential for ovarian functions (PIP3 activates AKT signalling and signalling by ERBB4). In addition to hsa-miR-548ba, hsa-miR-548o-3p is expressed in the myometrium, which separately targets the peroxisome proliferator-activated receptor alpha (PPARA) pathway. Conclusion: This study reveals that hsa-mir-548 family members are expressed in variable combinations in the reproductive tract, where they potentially fulfil different regulatory roles. The results provide a reference for further studies of the hsa-mir-548 family role in the reproductive tract.
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- Authors
- Rooda, I., Kaselt, B., Liivrand, M., Smolander, O.-P., Salumets, A., & Velthut-Meikas, A.
- Affiliations
- Tallinn University of Technology (EE)
- Karolinska Institutet (SE)
- Corresponding author
- Rooda, Ilmatar
- Venue
- BMC Genomic Data
- Published
- 2021-10-08
- Volume
- 22
- Issue
- 1
- Pages
- 40-40
- ISSN
- 2730-6844 (ISSN-L)
- PMC
- PMC8501715
- OpenAlex
- W3202852421
- Semantic Scholar
- 5ed94e9eca8661b01ab09f066d87ce5722f5c644
- Cited by
- 17
- References
- 67
- Citations by year
- 2025: 7 · 2024: 6 · 2023: 2 · 2022: 2
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Genomic Data (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- European Commission (EU48695, 2014‐2020, 2020 ‘, HORIZON2020, 952516)
- Eesti Teadusagentuur (2014-2020.4.01.16-0032, PRG1076, 2014-2020, PSG433, PSG608)
- Tallinna Tehnikaülikool (2014-2020.4.01.16.0032, project code 2014-2020.4.01.16-0032)
- Ettevõtluse Arendamise Sihtasutus (EU48695)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- granulosa cells, myometrium, FSH receptor, follicle-stimulating hormone, PTEN, LIFR, reproductive tissues
- MeSH terms
- Female, Ovarian Follicle, Granulosa Cells, Humans, Signal Transduction, Sequence Analysis, RNA, Databases, Genetic, MicroRNAs
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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