The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Short‐term efficacy of pharmacotherapeutic interventions in osteoarthritic knee pain: A meta‐analysis of randomised placebo‐controlled trials
Abstract
Background: Pain is the most debilitating symptom in osteoarthritis of the knee (OAK). Aim and methods: To determine the short‐term pain‐relieving effects of seven commonly used pharmacological agents for OAK pain by performing a systematic review of randomised placebo‐controlled trials. Results: In total, 14,060 patients in 63 trials were evaluated. Opioids and oral NSAIDs therapy in patients with moderate to severe pain (mean baseline 64.3 and 72.8mm on VAS respectively) had maximum efficacies compared to placebo at 2–4 weeks of 10.5mm [95% CI: 7.4–13.7] and 10.2mm [95% CI: 8.8–11.2] respectively. The efficacy of opioids may be inflated by high withdrawal rates (24–50%) and “best‐case” scenarios reported in intention‐to‐treat analyses. In patients with moderate pain scores on VAS (mean range from 51 to 57mm), intra‐articular steroid injections and topical NSAIDs had maximum efficacies at 1–3 weeks of 14.5mm [95% CI: 9.7–19.2] and 11.6 mm [95% CI: 7.4–15.7], respectively. Paracetamol, glucosamin sulphate and chondroitin sulphate had maximum mean efficacies at 1–4 weeks of only 4.7mm or lower. Heterogeneity tests revealed that best efficacy values of topical NSAIDs may be slightly deflated, while data for oral NSAIDs may be slightly inflated due to probable patient selection bias. Conclusion: Clinical effects from pharmacological interventions in OAK are small and limited to the first 2–3 weeks after start of treatment. The pain‐relieving effects over placebo in OAK are smaller than the patient‐reported thresholds for relevant improvement.
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Cited by
Dworkin, R. H., Turk, D. C., McDermott, M. P., Peirce-Sandner, S., Burke, L. B., Cowan, P., Farrar, J. T., Hertz, S., Raja, S. N., Rappaport, B. A., et al. (2009) · Pain · doi:10.1016/j.pain.2009.08.019 · Cited by 654
Small study effects in meta-analyses of osteoarthritis trials: meta-epidemiological study
Nuesch, E., Trelle, S., Reichenbach, S., Rutjes, A. W. S., Tschannen, B., Altman, D. G., Egger, M., & Juni, P. (2010) · BMJ · doi:10.1136/bmj.c3515 · Cited by 559
da Costa, B. R., Reichenbach, S., Keller, N., Nartey, L., Wandel, S., Jüni, P., & Trelle, S. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31744-0 · Cited by 522
RetractedTopical NSAIDs for chronic musculoskeletal pain in adults
Derry, S., Conaghan, P., Da Silva, J. A. P., Wiffen, P. J., & Moore, R. A. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007400.pub3 · Cited by 388
Meta-analysis: Chondroitin for Osteoarthritis of the Knee or Hip
Reichenbach, S., Sterchi, R., Scherer, M., Trelle, S., Bürgi, E., Bürgi, U., Dieppe, P. A., & Jüni, P. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-8-200704170-00009 · Cited by 316
Metadata
- Authors
- Bjordal, J. M., Klovning, A., Ljunggren, A. E., & Slørdal, L.
- Venue
- European Journal of Pain
- Publisher
- Wiley
- Published
- 2007-02
- Volume
- 11
- Issue
- 2
- Pages
- 125-138
- ISSN
- 1090-3801 (ISSN-L)
- 1532-2149
- OpenAlex
- W2035833931
- Cited by
- 296
- References
- 78
- FWCI
- 8.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bjordal, J. M., Klovning, A., Ljunggren, A. E., & Slørdal, L. (2007). Short‐term efficacy of pharmacotherapeutic interventions in osteoarthritic knee pain: A meta‐analysis of randomised placebo‐controlled trials. European Journal of Pain. https://doi.org/10.1016/j.ejpain.2006.02.013
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