The DOI matches its Crossref record; 221 of the 221 references it cites were found in a registry or an index.
Aliphatic polyesters for medical imaging and theranostic applications
Open accessAbstract
Medical imaging is a cornerstone of modern medicine. In that context the development of innovative imaging systems combining biomaterials and contrast agents (CAs)/imaging probes (IPs) for improved diagnostic and theranostic applications focuses intense research efforts. In particular, the classical aliphatic (co)polyesters poly(lactide) (PLA), poly(lactide-co-glycolide) (PLGA) and poly(ɛ-caprolactone) (PCL), attract much attention due to their long track record in the medical field. This review aims therefore at providing a state-of-the-art of polyester-based imaging systems. In a first section a rapid description of the various imaging modalities, including magnetic resonance imaging (MRI), optical imaging, computed tomography (CT), ultrasound (US) and radionuclide imaging (SPECT, PET) will be given. Then, the two main strategies used to combine the CAs/IPs and the polyesters will be discussed. In more detail we will first present the strategies relying on CAs/IPs encapsulation in nanoparticles, micelles, dendrimers or capsules. We will then present chemical modifications of polyesters backbones and/or polyester surfaces to yield macromolecular imaging agents. Finally, opportunities offered by these innovative systems will be illustrated with some recent examples in the fields of cell labeling, diagnostic or theranostic applications and medical devices.
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“Good biocompatibility also ensures that there is no inflammatory reaction in the surrounding tissue due to rejection after it enters the human body [75,76,77].”
From Synthesis and Biological Application of Polylactic Acid (2020) · cites this paper as [76]
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Sorted by citations
Polylactic acid (PLA) controlled delivery carriers for biomedical applications
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Synthesis and Biological Application of Polylactic Acid
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Metadata
- Authors
- Nottelet, B., Darcos, V., & Coudane, J.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Nottelet, Benjamin
- Venue
- European Journal of Pharmaceutics and Biopharmaceutics
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 97
- Issue
- Pt B
- Pages
- 350-370
- ISSN
- 0939-6411 (ISSN-L)
- OpenAlex
- W2211301183
- Cited by
- 68
- References
- 221
- Citations by year
- 2025: 4 · 2024: 5 · 2023: 9 · 2022: 6 · 2021: 4 · 2020: 7 · 2019: 11 · 2018: 6 · 2017: 4 · 2016: 11 · 2015: 1
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Pharmaceutics and Biopharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-nc-nd)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- aliphatic polyesters, polylactic acid, poly(lactic-co-glycolic acid), polycaprolactone, contrast media, imaging agents, theranostics, magnetic resonance imaging, optical imaging, computed tomography, ultrasonography, SPECT, PET, nanoparticle encapsulation, micelles, dendrimers, capsules, surface modification, cell labeling, medical devices
- MeSH terms
- Theranostic Nanomedicine, Polylactic Acid-Polyglycolic Acid Copolymer, Contrast Media, Diagnostic Imaging, Magnetic Resonance Imaging, Polyesters, Polyglycolic Acid, Tomography, X-Ray Computed, Tomography, Emission-Computed, Single-Photon, Lactic Acid
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