The DOI matches its Crossref record; 221 of the 221 references it cites were found in a registry or an index.
Aliphatic polyesters for medical imaging and theranostic applications
Open accessAbstract
Medical imaging is a cornerstone of modern medicine. In that context the development of innovative imaging systems combining biomaterials and contrast agents (CAs)/imaging probes (IPs) for improved diagnostic and theranostic applications focuses intense research efforts. In particular, the classical aliphatic (co)polyesters poly(lactide) (PLA), poly(lactide-co-glycolide) (PLGA) and poly(ɛ-caprolactone) (PCL), attract much attention due to their long track record in the medical field. This review aims therefore at providing a state-of-the-art of polyester-based imaging systems. In a first section a rapid description of the various imaging modalities, including magnetic resonance imaging (MRI), optical imaging, computed tomography (CT), ultrasound (US) and radionuclide imaging (SPECT, PET) will be given. Then, the two main strategies used to combine the CAs/IPs and the polyesters will be discussed. In more detail we will first present the strategies relying on CAs/IPs encapsulation in nanoparticles, micelles, dendrimers or capsules. We will then present chemical modifications of polyesters backbones and/or polyester surfaces to yield macromolecular imaging agents. Finally, opportunities offered by these innovative systems will be illustrated with some recent examples in the fields of cell labeling, diagnostic or theranostic applications and medical devices.
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“Good biocompatibility also ensures that there is no inflammatory reaction in the surrounding tissue due to rejection after it enters the human body [75,76,77].”
From Synthesis and Biological Application of Polylactic Acid (2020) · cites this paper as [76]
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Items 201–221 of 221
Hepatic targeting of macromolecular MRI contrast agents
Yan, G., Zhuo, R., Mian-yi, X., et al. (2002) · Polymer International · doi:10.1002/pi.922 · Cited by 15
Mekkapat, S., Thong-On, B., Rutnakornpituk, B., et al. (2013) · Journal of Nanoparticle Research · doi:10.1007/s11051-013-2051-1 · Cited by 13
MRI-visible nanoparticles from hydrophobic gadolinium poly(ε-caprolactone) conjugates
Porsio, B., Lemaire, L. P., Habnouni, S. E., et al. (2014) · Polymer · doi:10.1016/j.polymer.2014.11.031 · Cited by 13
Kaplun, V., & Stepensky, D. (2014) · Molecular Pharmaceutics · doi:10.1021/mp500253r · Cited by 13
Hallouard, F., Briancon, S., Anton, N., Li, X., Vandamme, T., & Fessi, H. (2013) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.23722 · Cited by 12
Synthesis and Properties of a Biodegradable Dendritic Magnetic Resonance Imaging Contrast Agent
Li, T., Qian, Y., Ye, M., et al. (2014) · Chinese Journal of Chemistry · doi:10.1002/cjoc.201300889 · Cited by 11
Pashkunova-Martic, I., Kremser, C., Galanski, M. S., et al. (2010) · Molecular Imaging and Biology · doi:10.1007/s11307-010-0358-1 · Cited by 11
Bennewitz, M. F., Williams, S. S., Nkansah, M. K., et al. (2013) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2013.7435 · Cited by 11
Rode, C., Schmidt, A., Wyrwa, R., Weisser, J., Schmidt, K., Moszner, N., Gottlöber, R., Heinemann, K., & Schnabelrauch, M. (2014) · Polymer International · doi:10.1002/pi.4707 · Cited by 10
Xu, B., Lu, R., Dou, H., et al. (2012) · Colloid & Polymer Science · doi:10.1007/s00396-012-2682-2 · Cited by 10
Ma, J., XING, L. X., Shen, M., et al. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.3072 · Cited by 9
Radio-opaque Micelles for X-ray Imaging
Wang, Z., Chang, T., Hunter, L., et al. (2013) · Australian Journal of Chemistry · doi:10.1071/ch13391 · Cited by 9
Tailoring the magnetic behavior of polymeric particles for bioapplications
Yakar, A., Tansık, G., Keskin, T., & Gündüz, U. (2013) · Journal of Polymer Engineering · doi:10.1515/polyeng-2012-0034 · Cited by 8
Franklin‐Ford, T., Shah, N. R., Leiferman, E. M., Chamberlain, C. S., Raval, A. N., Vanderby, R., & Murphy, W. L. (2012) · Macromolecular Bioscience · doi:10.1002/mabi.201100489 · Cited by 5
Guillaume, O., Blanquer, S., Letouzey, V., et al. (2012) · IRBM · doi:10.1016/j.irbm.2012.01.007 · Cited by 3
Nanocapsules of perfluorooctyl bromide for theranostics: from formulation to targeting
Diou, O., Fattal, E., Payen, T., et al. (2014) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.2037162 · Cited by 3
El‐Batta, A., Al-Muallem, H. A., Shaikh, M. N., et al. (2014) · PubMed · Cited by 3
Guillaume, O., Blanquer, S., Letouzey, V., et al. (2012) · IRBM · Cited by 3
Peng, K., Wang, S., Hua, M., & Lee, R. (2012) · Journal of Polymer Research · doi:10.1007/s10965-012-0062-8 · Cited by 2
NMR RELAXIVITY AND IMAGING OF NEUTRAL MACROMOLECULAR POLYESTER GADOLINIUM(III)COMPLEXES
叶朝辉 (1999) · Acta Scientiarum Naturalium Universitatis Sunyatseni · Cited by 1
NMR relaxivity and imaging of neutral macromolecular polyester gadolinium (III) complexes
Kai-chao, Y., Hu, H., Liu, M.-L., et al. (1999) · 高分子科学 · Cited by 1
Research works printed but not linked: 2
- Bai, 1998, Synthesis and characterization of polyester Gd(III) complexes, Acta Polym. Sin., 191
- Dormer, 2008, Magnetically-targeted, technetium 99m-labeled nanoparticles to the inner ear, J. Biomed. Nanotechnol., 4, 174
Cited by
Sorted by citations
Polylactic acid (PLA) controlled delivery carriers for biomedical applications
Tyler, B., Gullotti, D., Mangraviti, A., Utsuki, T., & Brem, H. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.06.018 · Cited by 1,050
Synthesis and Biological Application of Polylactic Acid
Li, G., Zhao, M., Xu, F., Yang, B., Li, X., Meng, X., Teng, L., Sun, F., & Li, Y. (2020) · Molecules · doi:10.3390/molecules25215023 · Cited by 492
Metadata
- Authors
- Nottelet, B., Darcos, V., & Coudane, J.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Nottelet, Benjamin
- Venue
- European Journal of Pharmaceutics and Biopharmaceutics
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 97
- Issue
- Pt B
- Pages
- 350-370
- ISSN
- 0939-6411 (ISSN-L)
- OpenAlex
- W2211301183
- Cited by
- 68
- References
- 221
- Citations by year
- 2025: 4 · 2024: 5 · 2023: 9 · 2022: 6 · 2021: 4 · 2020: 7 · 2019: 11 · 2018: 6 · 2017: 4 · 2016: 11 · 2015: 1
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Pharmaceutics and Biopharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-nc-nd)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- aliphatic polyesters, polylactic acid, poly(lactic-co-glycolic acid), polycaprolactone, contrast media, imaging agents, theranostics, magnetic resonance imaging, optical imaging, computed tomography, ultrasonography, SPECT, PET, nanoparticle encapsulation, micelles, dendrimers, capsules, surface modification, cell labeling, medical devices
- MeSH terms
- Theranostic Nanomedicine, Polylactic Acid-Polyglycolic Acid Copolymer, Contrast Media, Diagnostic Imaging, Magnetic Resonance Imaging, Polyesters, Polyglycolic Acid, Tomography, X-Ray Computed, Tomography, Emission-Computed, Single-Photon, Lactic Acid
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