Cited by 173Natural Antidiabetic Agents StudiesPancreatic function and diabetesMedicinal Plant Research

Antidiabetic activity of γ-sitosterol isolated from Lippia nodiflora L. in streptozotocin induced diabetic rats

Balamurugan, Rangachari, Duraipandiyan, Veeramuthu, Ignacimuthu, Savarimuthu·2011·European Journal of Pharmacology

Abstract

Lippia nodiflora L. (Verbenaceae) is a creeping perennial herb widely used in traditional system of medicine to treat ulcers, bronchitis and heart diseases; it also possesses antidiabetic property. In the present study, γ-sitosterol isolated from Lippia nodiflora was screened for its antidiabetic property in streptozotocin (STZ) induced diabetic rats. Insulin secretion in response to glucose was evaluated in isolated rat islets. Oral administration of γ-sitosterol (20 mg/kg body weight) once daily for 21 days in STZ-induced diabetic rats resulted in a significant decrease in blood glucose and glycosylated hemoglobin with a significant increase in plasma insulin level, body weight and food intake. Furthermore γ-sitosterol showed antihyperlipidemic activity as evidenced by significant decrease in serum total cholesterol, triglycerides and very low density lipoprotein-cholesterol levels coupled with elevation of high density lipoprotein-cholesterol levels in treated rats. A significant decrease in the activities of alanine aminotransaminase, aspartate aminotransaminase, alkaline phosphatase and acid phosphatase in γ-sitosterol treated rats when compared to diabetic control rats indicated its protective role against liver damage. γ-Sitosterol increased insulin secretion in response to glucose. Immunohistochemical study of pancreas also confirmed the biochemical findings. These results indicated that γ-sitosterol, the compound isolated from L. nodiflora, possessed antihyperglycemic activity.

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Crossref · 10.1016/j.ejphar.2011.05.025

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Authors
Balamurugan, R., Duraipandiyan, V., & Ignacimuthu, S.
Affiliations
Loyola College (IN)
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
2011-09
Volume
667
Issue
1-3
Pages
410-418
ISSN
0014-2999 (ISSN-L)
OpenAlex
W2065105404
Cited by
173
References
58
Citations by year
2026: 11 · 2025: 17 · 2024: 25 · 2023: 13 · 2022: 17 · 2021: 15 · 2020: 4 · 2019: 10 · 2018: 11 · 2017: 4 · 2016: 8 · 2015: 11 · 2014: 12 · 2013: 9 · 2012: 5
FWCI
7.08
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Indian Council of Medical Research
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords
γ-sitosterol, Lippia nodiflora, antidiabetic activity, streptozotocin-induced diabetes, insulin secretion, pancreatic islets, hypolipidemic activity, serum lipids, hepatoprotection, HbA1c, traditional medicine
MeSH terms
Insulin Secretion, Animals, Blood Glucose, Body Weight, Diabetes Mellitus, Experimental, Fasting, Glycogen, Glycated Hemoglobin, Hypoglycemic Agents, Insulin, Liver, Male, Muscles, Sitosterols, Biomarkers, Rats, Wistar, Lippia, Carbohydrate Metabolism, Lipid Metabolism, Rats

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