Glycan recognition at the interface of the intestinal immune system: target for immune modulation via dietary components
Abstract
The intestinal mucosa is constantly exposed to the luminal content, which includes micro-organisms and dietary components. Prebiotic non-digestible oligosaccharides may be supplemented to the diet to exert modulation of immune responses in the intestine. Short chain galacto- and long chain fructo-oligosaccharides (scGOS/lcFOS), functionally mimicking oligosaccharides present in human milk, have been reported to reduce the development of allergy through modulation of the intestinal microbiota and immune system. Nonetheless, the underlying working mechanisms of scGOS/lcFOS are unclear. Intestinal epithelial cells lining the mucosa are known to express carbohydrate (glycan)-binding receptors that may be involved in modulation of the mucosal immune response. This review aims to provide an overview of glycan-binding receptors, in particular galectins, which are expressed by intestinal epithelial cells and immune cells. In addition, their involvement in health and disease will be addressed, especially in food allergy and inflammatory bowel disease, diseases originating from the gastro-intestinal tract. Insight in the recognition of glycans in the intestinal tract may open new avenues for the treatment of intestinal inflammatory diseases by either nutritional concepts or pharmacological intervention.
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Prebiotic fibers added to the diet might explain its better effects on gastrointestinal function and motor function via beneficial effects on immune function, bowel motility, and microbiota composition that can alter the enteric immune and nervous system and subsequently the central nervous system.
“Prebiotic fibers added to the diet might explain its better effects on GI-function since GOS and FOS have shown to have beneficial effects on immune function (de Kivit et al., 2011), bowel motility (Meksawan et al., 2014;Scholtens et al., 2014), but they might also contribute to its better efficacy on motor-function since the prebiotic fibers might positively affect microbiota composition that in”
From The Gut-Brain Axis in Parkinson’s Disease: Possibilities for Food-Based Therapies (2017) · cites this paper as de Kivit et al., 2011
Prebiotic fibers have been shown to have beneficial effects on immune function, bowel motility and constipation that might be relevant for inflammation and gastrointestinal-related symptoms in Parkinson's disease.
“Prebiotic fibers have been shown to have beneficial effects on immune function (Jeurink et al., 2013)(de Kivit et al., 2011)(van Hoffen et al., 2009), bowel motility and constipation (Meksawan et al., 2014) (Scholtens et al., 2014) (Rasmussen et al., 2014) that might be very relevant for inflammation and GI-related symptoms in PD.”
From The Gut-Brain Axis in Parkinson’s Disease: Possibilities for Food-Based Therapies (2017) · cites this paper as de Kivit et al., 2011
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References 106 · Cited by 94
- Authors
- de Kivit, S., Kraneveld, A. D., Garssen, J., & Willemsen, L. E. M.
- Affiliations
- Utrecht University (NL)
- Danone (Netherlands) (NL)
- Corresponding author
- Willemsen, Linette E.M.
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 668
- Pages
- S124-S132
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2023516396
- Cited by
- 94
- References
- 106
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 2 · 2022: 5 · 2021: 11 · 2020: 4 · 2019: 7 · 2018: 2 · 2017: 10 · 2016: 2 · 2015: 5 · 2014: 11 · 2013: 15 · 2012: 10
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Top Institute Pharma
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Immunology and Microbiology › Immunology › Galectins and Cancer Biology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Keywords
- carbohydrate recognition, galectins, prebiotic oligosaccharides, intestinal mucosa, intestinal epithelial cells, gut microbiota, food allergy, inflammatory bowel disease, immunomodulation, food components
- MeSH terms
- Animals, Diet, Diet Therapy, Humans, Immune System, Intestines, Polysaccharides, Immunomodulation
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