Up-regulation of glyoxalase 1 by mangiferin prevents diabetic nephropathy progression in streptozotocin-induced diabetic rats
Abstract
Advanced glycation endproducts (AGEs) and its precursor methylglyoxal are associated with diabetic nephropathy (DN). Mangiferin has many beneficial biological activities, including anti-inflammatory, anti-oxidative and anti-diabetic effects. We investigated the effect of mangiferin on DN and its potential mechanism associated with glyoxalase 1 (Glo-1), a detoxifying enzyme of methylglyoxal, in streptozotocin-induced rat model of DN. Diabetic rats were treated orally with mangiferin (15, 30, and 60 mg/kg) or distilled water for 9 weeks. Kidney tissues were collected for morphologic observation and the determination of associated biochemical parameters. The cultured mesangial cells were used to measure the activity of Glo-1 in vitro. Chronic treatment with mangiferin significantly ameliorated renal dysfunction in diabetic rats, as evidenced by decreases in albuminuria, blood urea nitrogen, kidney weight index, periodic acid-schiff stain positive mesangial matrix area, glomerular extracellular matrix expansion and accumulation, and glomerular basement membrane thickness. Meanwhile, mangiferin treatment caused substantial increases in the enzymatic activity of Glo-1 in vivo and in vitro, and protein and mRNA expression of Glo-1, reduced levels of AGEs and the protein and mRNA expression of their receptor (RAGE) in the renal cortex of diabetic rats. Moreover, mangiferin significantly attenuated oxidative stress damage as reflected by the lowered malondialdehyde and the increased g…
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In a STZ-induced DN rat model, oral mangiferin (15, 30 and 60 mg/kg) for 9 weeks decreased albuminuria, BUN, kidney weight index, PAS-positive mesangial matrix area, glomerular extracellular matrix expansion and accumulation and glomerular basement membrane thickness, via targeting glyoxalase 1.
“Similarly, in animal experiments performed by Liu et al (35) in an STZ-induced DN rat model, evidential decreases in albuminuria, BUN, kidney weight index, periodic acid-Schiff stain positive mesangial matrix area, glomerular extracellular matrix expansion and accumulation and glomerular basement membrane thickness were observed following oral mangiferin treatment (15, 30 and 60 mg/kg) for 9 weeks”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [35]
In a STZ-induced DN rat model, mangiferin did not improve body weight or blood glucose levels.
“These results validate the beneficial actions of mangiferin in DN, although body weight and blood glucose levels were not improved (35).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [35]
Cites
MIURA, T., ICHIKI, H., IWAMOTO, N., KATO, M., KUBO, M., SASAKI, H., OKADA, M., ISHIDA, T., SEINO, Y., & TANIGAWA, K. (2001) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.24.1009 · Cited by 137 · see citing works
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Mangiferin: An effective therapeutic agent against several disorders (Review)
Du, S., Liu, H., Lei, T., Xie, X., Wang, H., He, X., Tong, R., & Wang, Y. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9529 · Cited by 139 · see citing works
“Similarly, in animal experiments performed by Liu et al (35) in an STZ-induced DN rat model, evidential decreases in albuminuria, BUN, kidney weight index, periodic acid-Schiff stain positive mesangial matrix area, glomerular extracellular matrix expansion and accumulation and glomerular basement membrane thickness we…”
InfluentialHou, J., Zheng, D., Fung, G., Deng, H., Chen, L., Liang, J., Jiang, Y., & Hu, Y. (2016) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2015-0073 · Cited by 89 · see citing works
The management of diabetes mellitus by mangiferin: advances and prospects
Wang, M., Liang, Y., Chen, K., Wang, M., Long, X., Liu, H., Sun, Y., & He, B. (2022) · Nanoscale · doi:10.1039/d1nr06690k · Cited by 56 · see citing works
- Authors
- Liu, Y.-W., Zhu, X., Zhang, L., Lu, Q., Wang, J.-Y., Zhang, F., Guo, H., Yin, J.-L., & Yin, X.-X.
- Affiliations
- Xuzhou Medical College (CN)
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 721
- Issue
- 1-3
- Pages
- 355-364
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W1966623127
- Cited by
- 72
- References
- 1
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 8 · 2020: 9 · 2019: 8 · 2018: 10 · 2017: 3 · 2016: 6 · 2015: 6 · 2014: 6
- FWCI
- 14.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Jiangsu Province (BK2011208)
- China, Zhen Xing Project of XZMC, China
- Priority Academic Program Development of Jiangsu Higher Education Institutions, China
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- mangiferin, diabetic nephropathy, glyoxalase I, methylglyoxal, advanced glycation end products, RAGE, oxidative stress, albuminuria, mesangial expansion, glomerular extracellular matrix, streptozotocin-induced diabetes, renal dysfunction
- MeSH terms
- Receptor for Advanced Glycation End Products, Animals, Blood Glucose, Body Weight, Diabetes Mellitus, Experimental, Diabetic Nephropathies, Fasting, Lactoylglutathione Lyase, Male, Receptors, Immunologic, RNA, Messenger, Up-Regulation, Glycation End Products, Advanced, Rats, Sprague-Dawley, Oxidative Stress, Disease Progression, Xanthones, Rats
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