The role of ASCT2 in cancer: A review

Liu, Yang, Zhao, Tingli, Li, Zhengzheng, Wang, Lai, Yuan, Shengtao, Sun, Li·2018·European Journal of Pharmacology

Cited by (162)

Items 101–162 of 162

  1. Asparagine transport through SLC1A5 / ASCT2 and SLC38A5 / SNAT5 is essential for BCP‐ALL cell survival and a potential therapeutic target
    Giuseppe Taurino, Erica Dander, Martina Chiu, Giulia Pozzi, Chiara Maccari, Rita Starace, Daniela Silvestri, Erika Griffini, Massimiliano Giovanni Bianchi, Cecilia Carubbi et al. · 2024 · British Journal of Haematology
  2. Tumor Metabolism: A New Field for the Treatment of Glioma
    Xiaoqian Chai, Yingjie Zhang, Wen Zhang, Kuanhan Feng, Yingyu Jiang, Anran Zhu, Xiaojin Chen, Liuqing Di, Ruoning Wang · 2024 · Bioconjugate Chemistry
  3. ASCT2 palmitoylation regulated by JNK1-ZDHHC14 axis orchestrates glutamine metabolism and NSCLC progression
    Xingyu Chen, Zihao Ke, Shihui Wei, Jiajin Chen, Ke Zhu, Jiaqi Xu, Yun Zhao, Mengyuan Cen, Yan Jin, Zhilei Pan et al. · 2026 · Cell Discovery
  4. Preclinical radiolabeling, in vivo biodistribution and positron emission tomography of a novel pyrrolobenzodiazepine (PBD)-based antibody drug conjugate targeting ASCT2
    Christian Werner Wichmann, Ingrid J.G. Burvenich, Nancy Yanan Guo, Angela Rigopoulos, Alexander Franklin McDonald, Diana Cao, Graeme Joseph O'Keefe, Sylvia Jie Gong, Hui Kong Gan, Fiona Elizabeth Scott et al. · 2023 · Nuclear Medicine and Biology
  5. CircCPA4 induces ASCT2 expression to promote tumor property of non‐small cell lung cancer cells in a miR‐145‐5p ‐dependent manner
    Zhenhua Zhang, Weiliang Liu, Tao Huang, Junyan Li, Hui Hu, Xinyu Xu, Zhigang Fan · 2024 · Thoracic Cancer
  6. Circular RNA circ-AGFG1 contributes to esophageal squamous cell carcinoma progression and glutamine catabolism by targeting microRNA-497-5p/solute carrier family 1 member 5 axis
    Siyang Chen, Zhizhen Liu, Qiang Feng, Jin-shan Zhou, Junchao Huang, Jianghao Yu · 2022 · Anti-Cancer Drugs
  7. SLC1A5 regulates cell proliferation and self-renewal through β-catenin pathway mediated by redox signaling in arsenic-treated uroepithelial cells
    Sihao Li, Liang Pei, Qing Zhou, Zhushan Fu, Lei Zhang, Pinya Liu, Nan Yan, Shuhua Xi · 2023 · Ecotoxicology and Environmental Safety
  8. The Synthesis and Biological Applications of the 1,2,3-Dithiazole Scaffold
    Andreas S. Kalogirou, Hans J. Oh, Christopher R. M. Asquith · 2023 · Molecules
  9. LAT1 and ASCT2 Related microRNAs as Potential New Therapeutic Agents against Colorectal Cancer Progression
    Francisca Dias, Cristina Almeida, Ana Luísa Teixeira, Mariana Morais, Rui Medeiros · 2021 · Biomedicines
  10. Metabolism and spatial transcription resolved heterogeneity of glutamine metabolism in cervical carcinoma
    Qian Liu, Jiayu Zhu, Guzhalinuer Abulizi, Ayshamgul Hasim · 2024 · BMC Cancer
  11. Crosstalk of glutamine metabolism between cancer-associated fibroblasts and cancer cells
    Tingyu Chen, Yiming Xu, Fan Yang, Yanxin Pan, Ning Ji, Jing Li, Xin Ying Zeng, Qianming Chen, Lu Jiang, Yingqiang Shen · 2025 · Cellular Signalling
  12. Relationships between Slc1a5 and Osteoclastogenesis
    Hideki Tsumura, Miyuki Shindo, Morihiro Ito, Arisa Igarashi, Kazue Takeda, Kenji Matsumoto, Takashi Ohkura, Kenji Miyado, Fumihiro Sugiyama, Akihiro Umezawa et al. · 2021 · Comparative Medicine
  13. Synthetic oleanane triterpenoid derivative CDDO‐Me disrupts cellular bioenergetics to suppress pancreatic ductal adenocarcinoma via targeting SLC1A5
    Percy David Papa Akuetteh, Huimin Huang, Shijia Wu, Hongfei Zhou, Guihua Jin, Welong Hong, Hongbao Yang, Linhua Lan, Fugen Shangguan, Qiyu Zhang · 2022 · Journal of Biochemical and Molecular Toxicology
  14. Design strategies and recent development of bioactive modulators for glutamine transporters
    Xinying Cheng, Yezhi Wang, Guangyue Gong, Pei Shen, Zhiyu Li, Jinlei Bian · 2024 · Drug Discovery Today
  15. Metabolic reprogramming in the CLL TME; potential for new therapeutic targets
    Helga Simon‐Molas, Chiara Montironi, Anna Kabanova, Eric Eldering · 2024 · Seminars in Hematology
  16. Alanine-serine-cysteine transporter-targeted small-molecule boron carriers for neutron capture therapy of L-4‑boronophenylalanine-refractory tumors
    Kazuki Miura, Tomoyuki Araki, Taiki Morita, Kai Nishimura, Satoshi Okada, Minoru Suzuki, Hiroyuki Nakamura · 2025 · Journal of Controlled Release
  17. Phosphoproteomics Analysis Reveals a Pivotal Mechanism Related to Amino Acid Signals in Goat Fetal Fibroblast
    Zheng Xu, Su Huimin, Liping Wang, Ruiyuan Yao, Yuze Ma, Linfeng Bai, Yanfeng Wang, Xudong Guo, Zhigang Wang · 2021 · Frontiers in Veterinary Science
  18. Circular RNA in Non-small Cell Lung Carcinoma: Identification of Targets and New Treatment Modalities
    Ulrich H. Weidle, Fabian Birzele · 2023 · Cancer Genomics & Proteomics
  19. Elucidation and Regulation of Tyrosine Kinase Inhibitor Resistance in Renal Cell Carcinoma Cells from the Perspective of Glutamine Metabolism
    Kento Morozumi, Yoshihide Kawasaki, Tomonori Sato, Masamitsu Maekawa, Shinya Takasaki, Shuichi Shimada, Takanari Sakai, Shinichi Yamashita, Nariyasu Mano, Akihiro Ito · 2024 · Metabolites
  20. Metabolism of Tryptophan, Glutamine, and Asparagine in Cancer Immunotherapy—Synergism or Mechanism of Resistance?
    Kajetan Kiełbowski, Estera Bakinowska, Rafał Becht, Andrzej Pawlik · 2025 · Metabolites
  21. Monoclonal Antibodies Against Myeloid Leukemia Cells: Current Knowledge and Future Directions
    Daniela Damiani, Mario Tiribelli · 2025 · International Journal of Molecular Sciences
  22. Useful genes for predicting the efficacy of transarterial chemoembolization in hepatocellular carcinoma
    Yuan Guo, Hongtao Hu, Shi‐Jun Xu, Weili Xia, Hai-Liang Li · 2022 · Journal of Cancer Research and Therapeutics
  23. The Regulation and Function of the Amino Acid Transporters LAT1, ASCT2, xCT in Urological Cancers
    Xue Zhao, Shinichi Sakamoto, Shinpei Saito, Sangjon Pae, Yasutaka Yamada, Sanji Kanaoka, Jiaxing Wei, Yusuke Goto, Tomokazu Sazuka, Yusuke Imamura et al. · 2024 · Receptors
  24. Imaging the uptake and metabolism of glutamine in prostate tumor models using CEST MRI
    Yuki Hodo, Caitlin M. Tressler, Behnaz Ghaemi, Rebecca L. Thomas, Aliyah S. Webster, Kirsten N. Bains Williams, Yuguo Li, Martin G. Pomper, Chi Van Dang, Zaver M. Bhujwalla et al. · 2025 · npj Imaging
  25. Glu‐derived Zwitterionic Micelles Conquering the Intestinal Mucosal Barrier toward Oral Delivery
    Kedong Liu, Yun Chen, Dutao Yang, Yanfei Cai, Zhaoqi Yang, Jian Jin · 2023 · ChemNanoMat
  26. Diseases & Disorders | Therapies Targeting Glutamine Addiction in Cancer
    Nabeel Attarwala, Cissy Zhang, Anne Le · 2020 · Elsevier eBooks
  27. Integrated stress response-upregulated mitochondrial SLC1A5var enhances glucose dependency in human breast cancer cells in vitro
    Sheng‐Fan Wang, Yu-Chieh Ho, Chian‐Ying Chou, Yuh‐Lih Chang, Hsin‐Chen Lee, Ling‐Ming Tseng · 2024 · The International Journal of Biochemistry & Cell Biology
  28. Biochemical Markers of Tumor Cell Sensitivity to L-Asparaginase
    Ilya A. Kislyak, Vadim S. Pokrovsky · 2023 · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry
  29. Deregulated circRNAs in Epithelial Ovarian Cancer With Activity in PreclinicalIn VivoModels: Identification of Targets and New Modalities for Therapeutic Intervention
    Ulrich H. Weidle, Fabian Birzele · 2024 · Cancer Genomics & Proteomics
  30. Causality Between Immune Cells, Metabolites and Breast Cancer: Mendelian Randomization and Mediation Analysis
    Changlong Wei, Changwang Li, Gongyin Zhang, Honghui Li, Jingsong Li, Jinsheng Zeng · 2024 · Biochemical Genetics
  31. Therapeutic Targeting of Glutamine Metabolism in Colorectal Cancer
    Yashwant Kumar Ratre, Henu Kumar Verma, Arundhati Mehta, Vivek Kumar Soni, Subash Chandra Sonkar, Dhananjay Shukla, Alka Ekka, Santosh Kumar Prajapati, Shakuntala Mahilkar, Naveen Kumar Vishvakarma · 2021 · Springer eBooks
  32. A Combined SIRT5 Activation and SIRT3 Inhibition Prevents Breast Cancer Spheroids Growth by Reducing HIF-1α and Mitophagy
    Federica Barreca, Michele Aventaggiato, Mario Cristina, Luigi Sansone, Manuel Belli, Maria Beatrice Lista, Gaia Francisci, Sérgio Valente, Dante Rotili, Antonello Mai et al. · 2025 · Pharmaceuticals
  33. Salubrinal-activated integrated stress response protects against doxorubicin-induced cardiotoxicity via activating transcription factor 4-mediated antioxidant defense and glutathione homeostasis
    Sheng‐Fan Wang, Hsuan-Yu Chou, Pei-Hsun Liu, Hsing-Hui Su, Giun‐Yi Hung, Chian‐Ying Chou, Ling‐Ming Tseng, Yuh‐Chiang Shen, Jiin‐Cherng Yen, Shiang‐Suo Huang et al. · 2026 · Free Radical Biology and Medicine
  34. CircRNAs as central regulators of Immunometabolic crosstalk in hepatocellular carcinoma
    Seerwan Hamadameen Sulaiman, Rebaz Anwar Omer, Hemn A.H. Barzani, Hunar Yasin Muhammad, Avan Bazid Qader, Evan Hashm Muhammad, Darya Kaife Muhammad, Sara Wezhawan Ahmad, Hoshyar Saadi Ali · 2026 · Clinica Chimica Acta
  35. Gallic acid markedly stimulates GLUT1-mediated glucose uptake by the AsPC-1 pancreatic cancer cell line
    Sílvia M. Torres, Francisca Carmo, Luís C. Monteiro, Cláudia Silva, Nelson Andrade, Fátima Martel · 2023 · Canadian Journal of Physiology and Pharmacology
  36. In vitro evaluation of (S)-2-amino-3-[3-(2-18F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (18F-FIMP) as a positron emission tomography probe for imaging amino acid transporters
    Satoshi Nozaki, Yuka Nakatani, Aya Mawatari, W. Ewan Hume, Hisashi Doi, Yasuyoshi Watanabe · 2023 · EJNMMI Research
  37. Actividad antitumoral de complejos de cobre(II) con fenantrolina y dipéptidos en células de cáncer de mama
    Katherine Seneth Muñoz Garzón, Natalia Álvarez, Gianella Facchin, Beatriz D. Soria, Ana Laura Di Virgilio · 2024 · Revista Colombiana de Hematología y Oncología
  38. The cytotoxic effect of crocin and chrysin on the AsPC-1 pancreatic cancer cell line is related to inhibition of nutrient uptake
    Sara Pinto, Nelson Andrade, Francisca Carmo, Cláudia Silva, Fátima Martel · 2025 · PharmaNutrition
  39. Integrating transcriptomic and metabolomic analyses to characterize the potential function of SLC1A5 in thyroid cancer
    Fengling Shan, Lan Wang, Xinyu Lu, Meihong Zhou, Zi Wang, Jingjing Lou, Xingdang Liu · 2025 · BMC Cancer
  40. Glutaminase inhibition confers antitumor effects in vitro and in vivo on tyrosine kinase inhibitors-resistant renal cell carcinoma cells by affecting vascular endothelial growth factor signaling
    Kento Morozumi, Yoshihide Kawasaki, Izumi Sakamoto, Tomonori Sato, Masamitsu Maekawa, Shinya Takasaki, Shinichi Yamashita, Nariyasu Mano, Akihiro Ito · 2025 · Biomedicine & Pharmacotherapy
  41. Recent progress of amino acid transporters as a novel antitumor target
    Ji-Ye Zhao, Jiayi Lv, Yang Chen, Qi Dong, Hao-Rong Dong · 2022 · Open Chemistry
  42. Discovery and Synthesis of Hydroxy-l-Proline Blockers of the Neutral Amino Acid Transporters SLC1A4 (ASCT1) and SLC1A5 (ASCT2)
    Brent R. Lyda, Gregory P. Leary, Jill C. Farnsworth, Derek Silvius, Benjamin Seaver, C. Sean Esslinger, Nicholas R. Natale, Michael P. Kavanaugh · 2024 · Molecules
  43. Transporter-Mediated Drug Delivery
    Gergely Gyimesi, Matthias A. Hediger · 2022 · Preprints.org
  44. Glutamine transporters as effective targets in digestive system malignant tumor treatment
    FEI CHU, KAI TONG, Xiang Gu, MEI BAO, Yanfen Chen, Bin Wang, YANHUA SHAO, Ling Wei · 2024 · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
  45. Reproducibility and repeatability of 18F-(2S, 4R)-4-fluoroglutamine PET imaging in preclinical oncology models
    Gregory Daniel Ayers, Allison S. Cohen, Seong-Woo Bae, Xiaoxia Wen, Alyssa C. Pollard, Shilpa Sharma, Trey Claus, Adria C. Payne, Ling Geng, Ping Zhao et al. · 2025 · PLoS ONE
  46. Analysis of a pan‑cancer panel reveals the amino acid metabolism‑related gene MTHFD1 as a potential prognostic and immunotherapeutic biomarker
    Shunsong Gong, Jiaxue Yang, Chao Pan, Peng Fenglan, Chuan Pan · 2025 · Experimental and Therapeutic Medicine
  47. Lapatinib induces ferroptosis in osteosarcoma via the SLC1A5-GPX4 axis
    Haichuan Miao, Xijia Fu, Baolong Liu, Xinfang Pan, Yahao Han, Zhongshen Yu · 2026 · Journal of bone oncology
  48. Peptides or Amino Acids?—‘The Smaller, the Better?’
    Christian E. W. Steinberg · 2022 · Springer eBooks
  49. [Value of prediction models for prognosis prediction of colorectal cancer: an analysis based on TCPA database].
    H Wen, Weikun Shi, Shuguang Ge, J Li, Lugen Zuo, M Liu · 2021 · PubMed Central
  50. Glutamine metabolism in prostate cancer
    Tomas Koltai, Stephan J. Reshkin, Fátima Baltazar, Larry Fliegel · 2021 · Elsevier eBooks
  51. Nutrient Transporters: New Molecular Targets for Triple Negative Breast Cancer in Type 2 Diabetics
    Cláudia Silva, Fátima Martel · 2022 · Interdisciplinary cancer research
  52. Expression of Alanine-Serine-Cysteine Transporter 2 (ASCT2) and L-type Amino Acid Transporter 1 (LAT1) in Low-Grade and High-Grade Gliomas: An Analysis of Open-Access Immunohistochemical Data
    William T Han, Nina H. Cheng, Najib Muhammad, John Y. K. Lee · 2025 · Cureus
  53. The differential effect of glutamine supplementation on the orthotopic and subcutaneous growth of two syngeneic murine models of glioma
    J Maurer, Purna Mukherjee, Nathan L. Ta, Derek C. Lee, Tomás Duraj, Juan Henao, Michael Kiebish, Devon Van Cura, Marialucia Herdocia, Thomas N. Seyfried · 2025 · ONCOLOGIE
  54. MRI of ASCT2-mediated amino acid uptake in xenograft tumor models
    Behnaz Ghaemi, Balaji Krishnamachary, Natalie Dillman, Kirsten N. Bains Williams, Yuki Hodo, Yuguo Li, Marie‐France Penet, Martin G. Pomper, Caitlin M. Tressler, Zaver M. Bhujwalla et al. · 2025 · Research Square
  55. Targeting Glutamine Transporters as a Novel Drug Therapy for Synovial Sarcoma
    Thanh Duc Tran, Naoki Takada, Hana Yao, Yoshitaka Ban, Naoto Oebisu, Manabu Hoshi, Nguyen Tran Quang Sang, Nguyen Van Khanh, Dang Minh Quang, Lê Thị Thanh Thủy et al. · 2025 · Cancers
  56. Additional file 1 of In vitro evaluation of (S)-2-amino-3-[3-(2-18F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (18F-FIMP) as a positron emission tomography probe for imaging amino acid transporters
    Nozaki, Satoshi, Yuka Nakatani, Aya Mawatari, W. Ewan Hume, Hisashi Doi, Watanabe, Yasuyoshi · 2023 · Figshare
  57. Additional file 1 of Elevated SLC1A5 associated with poor prognosis and therapeutic resistance to transarterial chemoembolization in hepatocellular carcinoma
    Guixiong Zhang, 萧贻泰, Jizhou Tan, Hang Liu, Fan, Wenzhe, Jiaping Li · 2024 · Figshare
  58. Additional file 1 of Blockade of the amino acid transporter SLC6A14 suppresses tumor growth in colorectal Cancer
    Lu, Ying, Ziting Jiang, Wang, Kaijing, Yu, Shanshan, Chongbo Hao, Zuan Ma, Fu, Xuelian, Qin, Ming Qing, Xu, Zengguang, 范列英 · 2022 · Figshare
  59. The tumor immune microenvironment in hepatocellular carcinoma: Its biological role in recurrence and metastasis
    Xia Sheng, Jian-Min Qin · 2026 · World Chinese Journal of Digestology
  60. Regulation of Amino Acid Transporters by Cell Surface Receptors
    Chiara Brignola, Myrhiam Cassese, S. Marrone, Teresa Esposito, Vincenza Barresi, Gabriella Esposito, D. F. Condorelli, Rosario Ammendola, Fabio Cattaneo · 2026 · Antioxidants
  61. NRF2 / xCT ‐Mediated Antioxidant Adaptation Attenuates Apoptosis Induced by ASCT2 Inhibition in Prostate Cancer
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  62. Excess glutamine rewires endothelial cell metabolism
    Marzyeh Kheradmand, Xinyao Zhou, Funke Okunrinboye, Ganesh Sriram, Alisa Morss Clyne · 2026 · Metabolomics