The role of ASCT2 in cancer: A review

The widespread regulation of microRNA biogenesis, function and decay

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Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation

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Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models

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SLC1A5 Mediates Glutamine Transport Required for Lung Cancer Cell Growth and Survival

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Targeting Glutamine Metabolism for Cancer Treatment

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Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia

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Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia

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Cloning of the Sodium-dependent, Broad-scope, Neutral Amino Acid Transporter Bo from a Human Placental Choriocarcinoma Cell Line

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Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells

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ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

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Regulation of Glutamine Carrier Proteins by RNF5 Determines Breast Cancer Response to ER Stress-Inducing Chemotherapies

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Targeting glutamine transport to suppress melanoma cell growth

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Adaptive Reprogramming of <i>De Novo</i> Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer

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A functional mammalian target of rapamycin complex 1 signaling is indispensable for c‐Myc‐driven hepatocarcinogenesis

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Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate

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Targeting SLC1a5 ‐mediated glutamine dependence in non‐small cell lung cancer

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Redox control of glutamine utilization in cancer

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Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer

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ASC amino-acid transporter 2 (ASCT2) as a novel prognostic marker in non-small cell lung cancer

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Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer

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ASCT2 silencing regulates mammalian target-of-rapamycin growth and survival signaling in human hepatoma cells

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Metabolic reprogramming of the tumor

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The endoplasmic reticulum–associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3–dependent degradation of nascent CFTRΔF508

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GLUT1 and ASCT2 as Predictors for Prognosis of Hepatocellular Carcinoma

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Nonessential amino acid metabolism in breast cancer

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Upregulated SLC1A5 promotes cell growth and survival in colorectal cancer.

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ASCT2 regulates glutamine uptake and cell growth in endometrial carcinoma

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GPNA inhibits the sodium-independent transport system l for neutral amino acids

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Clinical Role of ASCT2 (SLC1A5) in KRAS-Mutated Colorectal Cancer

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Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity

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Targeting of glutamine transporter ASCT2 and glutamine synthetase suppresses gastric cancer cell growth

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High expression of Solute Carrier Family 1, member 5 (SLC1A5) is associated with poor prognosis in clear-cell renal cell carcinoma

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2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport

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Epigenetic silencing of microRNA-137 enhances ASCT2 expression and tumor glutamine metabolism

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Increased Expression of the E3 Ubiquitin Ligase RNF5 Is Associated with Decreased Survival in Breast Cancer

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ASCT2 (SLC1A5)-Deficient Mice Have Normal B-Cell Development, Proliferation, and Antibody Production

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Effects of targeting SLC1A5 on inhibiting gastric cancer growth and tumor development in vitro and in vivo

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Establishment of monoclonal antibodies against cell surface domains of ASCT2/SLC1A5 and their inhibition of glutamine-dependent tumor cell growth

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2-Substituted Nγ-glutamylanilides as novel probes of ASCT2 with improved potency

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Anti-tumor efficacy evaluation of a novel monoclonal antibody targeting neutral amino acid transporter ASCT2 using patient-derived xenograft mouse models of gastric cancer.

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Relationship between CD147 and expression of amino acid transporters (LAT1 and ASCT2) in patients with pancreatic cancer.

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The clinical and prognostic correlation of HRNPM and SLC1A5 in pathogenesis and prognosis in epithelial ovarian cancer

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Glutamine reliance in cell metabolism

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A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells

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Solute carrier transporters: the metabolic gatekeepers of immune cells

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Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth

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ASCT2 (SLC1A5)-dependent glutamine uptake is involved in the progression of head and neck squamous cell carcinoma

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Amino Acid Transporters as Targets for Cancer Therapy: Why, Where, When, and How

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Amino acids and the regulation of oxidative stress and immune function in dairy cattle

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A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2

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Mitochondrial and metabolic alterations in cancer cells

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SLC1A5 enhances malignant phenotypes through modulating ferroptosis status and immune microenvironment in glioma

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Neddylation inhibition induces glutamine uptake and metabolism by targeting CRL3SPOP E3 ligase in cancer cells

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Role of glutamine and its metabolite ammonia in crosstalk of cancer-associated fibroblasts and cancer cells

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Amino Acid Transporters and Exchangers from the SLC1A Family: Structure, Mechanism and Roles in Physiology and Cancer

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Transporter-Mediated Drug Delivery

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ASCT2 and LAT1 Contribution to the Hallmarks of Cancer: From a Molecular Perspective to Clinical Translation

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Targeting metabolism to enhance immunotherapy within tumor microenvironment

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Cancer metabolism and intervention therapy

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Advances and Challenges in Rational Drug Design for SLCs

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Regulation of hepatic glutamine metabolism by miR-122

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The Structure and Mechanism of Drug Transporters

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Engineering extracellular vesicles to deliver CRISPR ribonucleoprotein for gene editing

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SLC1A5 provides glutamine and asparagine necessary for bone development in mice

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Transporters at the Interface between Cytosolic and Mitochondrial Amino Acid Metabolism

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Emerging roles of the solute carrier family in pancreatic cancer

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Gilteritinib Inhibits Glutamine Uptake and Utilization in FLT3 -ITD–Positive AML

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ASCT2 overexpression is associated with poor survival of OSCC patients and ASCT2 knockdown inhibited growth of glutamine‐addicted OSCC cells

Luo, Y., Li, W., Ling, Z., Hu, Q., Fan, Z., Cheng, B., & Tao, X. (2020) · Cancer Medicine · doi:10.1002/cam4.2965 · Cited by 46 · see citing works

Arsenic Trioxide Promotes Tumor Progression by Inducing the Formation of PGCCs and Embryonic Hemoglobin in Colon Cancer Cells

Li, Z., Zheng, M., Zhang, H., Yang, X., Fan, L., Fu, F., Fu, J., Niu, R., Yan, M., & Zhang, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.720814 · Cited by 45 · see citing works

The Role of Tumor Metabolic Reprogramming in Tumor Immunity

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Glycosylation and raft endocytosis in cancer

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Exploiting the Achilles' heel of cancer: disrupting glutamine metabolism for effective cancer treatment

Fan, Y., Xue, H., Li, Z., Huo, M., Gao, H., & Guan, X. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1345522 · Cited by 40 · see citing works

SLC1A5 Prefers to Play as an Accomplice Rather Than an Opponent in Pancreatic Adenocarcinoma

Xu, F., Wang, H., Pei, H., Zhang, Z., Liu, L., Tang, L., Wang, S., & Ren, B. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.800925 · Cited by 39 · see citing works

Oxidative stress promotes oral carcinogenesis via Thbs1-mediated M1-like tumor-associated macrophages polarization

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High Levels of Glutaminase II Pathway Enzymes in Normal and Cancerous Prostate Suggest a Role in ‘Glutamine Addiction’

Dorai, T., Dorai, B., Pinto, J. T., Grasso, M., & Cooper, A. J. L. (2019) · Biomolecules · doi:10.3390/biom10010002 · Cited by 38 · see citing works

Amino Acid Transporters on the Guard of Cell Genome and Epigenome

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ASCT2: a potential cancer drug target

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Anti‐tumor effects of an antagonistic mAb against the ASCT2 amino acid transporter on KRAS‐mutated human colorectal cancer cells

Hara, Y., Minami, Y., Yoshimoto, S., Hayashi, N., Yamasaki, A., Ueda, S., Masuko, K., & Masuko, T. (2019) · Cancer Medicine · doi:10.1002/cam4.2689 · Cited by 36 · see citing works

Targeting Glutamine Metabolism as an Attractive Therapeutic Strategy for Acute Myeloid Leukemia

Xiao, Y., Hu, B., Guo, Y., Zhang, D., Zhao, Y., Chen, Y., Li, N., & Yu, L. (2023) · Current Treatment Options in Oncology · doi:10.1007/s11864-023-01104-0 · Cited by 35 · see citing works

Identification and Characterization of IMD-0354 as a Glutamine Carrier Protein Inhibitor in Melanoma

Feng, Y., Pathria, G., Heynen‐Genel, S., Jackson, M., James, B. P., Yin, J., Scott, D. A., & Ronai, Z. A. (2021) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-20-0354 · Cited by 35 · see citing works

Impeding the combination of astrocytic ASCT2 and NLRP3 by talniflumate alleviates neuroinflammation in experimental models of Parkinson's disease

Liu, Y., Liu, T., Zhou, Y., Li, W., Wang, M., Song, N., Zhang, W., Jiang, J., Yuan, S., Ding, J., et al. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.07.021 · Cited by 35 · see citing works

Progress in research on the role of amino acid metabolic reprogramming in tumour therapy: A review

Wang, D., & Wan, X. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113923 · Cited by 34 · see citing works

E3 ubiquitin ligase RNF5 attenuates pathological cardiac hypertrophy through STING

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CAFs targeted ultrasound-responsive nanodroplets loaded V9302 and GLULsiRNA to inhibit melanoma growth via glutamine metabolic reprogramming and tumor microenvironment remodeling

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Rational combination with PDK1 inhibition overcomes cetuximab resistance in head and neck squamous cell carcinoma.

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Ginsenoside Rk1 regulates glutamine metabolism in hepatocellular carcinoma through inhibition of the ERK/c-Myc pathway

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Zwitterionic Amino Acid-Derived Polyacrylates as Smart Materials Exhibiting Cellular Specificity and Therapeutic Activity

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The Ubiquitin–Proteasome System in Tumor Metabolism

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Targeting Pulmonary Fibrosis by SLC1A5-Dependent Glutamine Transport Blockade

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Cryo-electron microscopy-based drug design

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Prostate Cancer Energetics and Biosynthesis

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Glutaminolysis is a metabolic route essential for survival and growth of prostate cancer cells and a target of 5α-dihydrotestosterone regulation

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First-in-Human PET Imaging and Estimated Radiation Dosimetry of l-[5-11C]-Glutamine in Patients with Metastatic Colorectal Cancer

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A Carbonic Anhydrase IX/SLC1A5 Axis Regulates Glutamine Metabolism Dependent Ferroptosis in Hypoxic Tumor Cells

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Monitoring and modelling the glutamine metabolic pathway: a review and future perspectives

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Exploring Amino Acid Transporters as Therapeutic Targets for Cancer: An Examination of Inhibitor Structures, Selectivity Issues, and Discovery Approaches

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The tRNA Gm18 methyltransferase TARBP1 promotes hepatocellular carcinoma progression via metabolic reprogramming of glutamine

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Lobetyolin inhibits the proliferation of breast cancer cells via ASCT2 down-regulation-induced apoptosis

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Correlation Between Prognostic Biomarker SLC1A5 and Immune Infiltrates in Various Types of Cancers Including Hepatocellular Carcinoma

Zhao, J., Yang, Z., Tu, M., Meng, W., Gao, H., Li, M. D., & Li, L. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.608641 · Cited by 29 · see citing works

The anti-proliferative effect of β-carotene against a triple-negative breast cancer cell line is cancer cell-specific and JNK-dependent

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c-Myc protects hepatocellular carcinoma cell from ferroptosis induced by glutamine deprivation via upregulating GOT1 and Nrf2

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Improving the Efficacy of EGFR Inhibitors by Topical Treatment of Cutaneous Squamous Cell Carcinoma with miR-634 Ointment

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Monocarboxylate Transporter-1 (MCT1)-Mediated Lactate Uptake Protects Pancreatic Adenocarcinoma Cells from Oxidative Stress during Glutamine Scarcity Thereby Promoting Resistance against Inhibitors of Glutamine Metabolism

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Metabolic Reprogramming of Cancer Cells and Therapeutics Targeting Cancer Metabolism

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Blockade of the amino acid transporter SLC6A14 suppresses tumor growth in colorectal Cancer

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Fine‐tuning osteoclastogenesis: An insight into the cellular and molecular regulation of osteoclastogenesis

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The Role of Metabolic Reprogramming in the Tumor Immune Microenvironment: Mechanisms and Opportunities for Immunotherapy in Hepatocellular Carcinoma

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The SLC38A5/SNAT5 amino acid transporter: from pathophysiology to pro-cancer roles in the tumor microenvironment

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Metabolic mechanisms of immunotherapy resistance

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Metabolic reprogramming of glutamine involved in tumorigenesis, multidrug resistance and tumor immunity

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lncRNA SYTL5-OT4 promotes vessel co-option by inhibiting the autophagic degradation of ASCT2

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The Whole Is Greater than the Sum of Its Parts – Challenges and Perspectives in Polyelectrolytes

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Autophagy in cancer: The cornerstone during glutamine deprivation

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Oncogenic viral infection and amino acid metabolism in cancer progression: Molecular insights and clinical implications

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Formyl-Peptide Receptor 2 Signaling Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming of Lung Cancer Cells

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A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer

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Elevated SLC1A5 associated with poor prognosis and therapeutic resistance to transarterial chemoembolization in hepatocellular carcinoma

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Breaking barriers: Engineering extracellular vesicles for enhanced endosomal escape and therapeutic delivery

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Synergism between SLC6A14 blockade and gemcitabine in pancreactic cancer: a 1H-NMR-based metabolomic study in pancreatic cancer cells

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L-type amino acid transporter 1, LAT1, in growth hormone-producing pituitary tumor cells

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Interactions between the metabolic reprogramming of liver cancer and tumor microenvironment

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The role and mechanism of action of microRNA-122 in cancer: Focusing on the liver

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Aberrant Metabolism as Inductor of Epigenetic Changes in Breast Cancer: Therapeutic Opportunities

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Inhibition of Glutamine Cellular Uptake Contributes to the Cytotoxic Effect of Xanthohumol in Triple-Negative Breast Cancer Cells

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ASCT2 Is Involved in SARS-Mediated β‑Casein Synthesis of Bovine Mammary Epithelial Cells with Methionine Supply

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Anti-tumor effects of P-LPK-CPT, a peptide-camptothecin conjugate, in colorectal cancer

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SLC1A5, unrelated to prognosis, was associated with CD8+ T-cell exclusion in the tumor microenvironment of squamous cell carcinoma

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Receptor-recognition and antiviral mechanisms of retrovirus-derived human proteins

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Immunological Aspects of Cancer Cell Metabolism

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Ag120-Mediated Inhibition of ASCT2-Dependent Glutamine Transport has an Anti-Tumor Effect on Colorectal Cancer Cells

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Amino Acid Transporters as Potential Therapeutic Targets in Thyroid Cancer

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V-9302 inhibits proliferation and migration of VSMCs, and reduces neointima formation in mice after carotid artery ligation

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LAMP2A overexpression in colorectal cancer promotes cell growth and glycolysis via chaperone‑mediated autophagy

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Cuscuta chinensis flavonoids alleviate ovarian damage in offspring female mice induced by BPA exposure during pregnancy by regulating the central carbon metabolism pathway

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ASCT2-Targeting Antibody-Drug Conjugate MEDI7247 in Adult Patients with Relapsed/Refractory Hematological Malignancies: A First-in-Human, Phase 1 Study

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Anti‐Tumor Strategies Targeting Nutritional Deprivation: Challenges and Opportunities

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[18F](2S,4R)-4-Fluoroglutamine as a New Positron Emission Tomography Tracer in Myeloma

Valtorta, S., Toscani, D., Chiu, M., Sartori, A. M., Coliva, A., Brevi, A., Taurino, G., Grioni, M., Ruffini, L., Vacondio, F., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.760732 · Cited by 12 · see citing works

Metabolic reprogramming in osteosarcoma

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ASCT2-mediated glutamine uptake promotes Th1 differentiation via ROS-EGR1-PAC1 pathway in oral lichen planus

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The pro-proliferative effect of interferon-γ in breast cancer cell lines is dependent on stimulation of ASCT2-mediated glutamine cellular uptake

Silva, C., Andrade, N., Rodrigues, I., Ferreira, A. C., Soares, M. L., & Martel, F. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120054 · Cited by 12 · see citing works

LncRNA SLC1A5-AS/MZF1/ASCT2 Axis Contributes to Malignant Progression of Hepatocellular Carcinoma

Jiang, J., Dong, W., Zhang, W., Wang, Q., Wang, R., Wang, J., Wu, H., Dong, H., Zhao, R. C., Wang, J., et al. (2023) · Discovery Medicine · doi:10.24976/discov.med.202335179.96 · Cited by 12 · see citing works

SLC38A2 Overexpression Induces a Cancer‐like Metabolic Profile and Cooperates with SLC1A5 in Pan‐cancer Prognosis

Huang, M., Chang, J., Lin, W., Cheng, Y., Li, F., Suen, C., Hwang, M., Chang, C., & Mou, K. Y. (2020) · Chemistry - An Asian Journal · doi:10.1002/asia.202001056 · Cited by 11 · see citing works

Research Progress of Glutamine Transporter ASCT2 in Cancer

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The role of the glutamine transporter ASCT2 in antineoplastic therapy

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Target the human Alanine/Serine/Cysteine Transporter 2(ASCT2): Achievement and Future for Novel Cancer Therapy

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Recent advances in ASCT2 inhibitors: ligand design and therapeutic applications

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Abstract 1166: ASCT2: A novel metabolic target for cancer therapy

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