The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Molecular targeted therapy: Treating cancer with specificity
Abstract
ABSTRACT Molecular targeted therapies are revolutionized therapeutics which interfere with specific molecules to block cancer growth, progression, and metastasis. Many molecular targeted therapies approved by the Food and Drug Administration (FDA), have demonstrated remarkable clinical success in the treatment of a myriad of cancer types including breast, leukemia, colorectal, lung, and ovarian cancers. This review provides an update on the different types of molecular targeted therapies used in the treatment of cancer, focusing on the fundamentals of molecular targeted therapy, its mode of action in cancer treatment, as well as its advantages and limitations.
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Cites
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CRISPR–Cas9 Structures and Mechanisms
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RAS isoforms and mutations in cancer at a glance
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Comprehensive review of targeted therapy for colorectal cancer
Xie, Y.-H., Chen, Y.-X., & Fang, J.-Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0116-z · Cited by 1,687
Antibody drug conjugate: the “biological missile” for targeted cancer therapy
Fu, Z., Li, S., Han, S., Shi, C., & Zhang, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00947-7 · Cited by 1,643
Molecular targeted therapy for anticancer treatment
Min, H.-Y., & Lee, H.-Y. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00864-3 · Cited by 569
The multi-factorial nature of clinical multidrug resistance in cancer
Assaraf, Y. G., Brozovic, A., Gonçalves, A. C., Jurkovicova, D., Linē, A., Machuqueiro, M., Saponara, S., Sarmento-Ribeiro, A. B., Xavier, C. P. R., & Vasconcelos, M. H. (2019) · Drug Resistance Updates · doi:10.1016/j.drup.2019.100645 · Cited by 528
Complex roles of cAMP–PKA–CREB signaling in cancer
Zhang, H., Kong, Q., Wang, J., Jiang, Y., & Hua, H. (2020) · Experimental Hematology & Oncology · doi:10.1186/s40164-020-00191-1 · Cited by 466
Metadata
- Authors
- Lee, Y. T., Tan, Y. J., & Oon, C. E.
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 834
- Pages
- 188-196
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2884126108
- Cited by
- 1,067
- References
- 8
- FWCI
- 43.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lee, Y. T., Tan, Y. J., & Oon, C. E. (2018). Molecular targeted therapy: Treating cancer with specificity. European Journal of Pharmacology. https://doi.org/10.1016/j.ejphar.2018.07.034
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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