The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.
Complex roles of cAMP–PKA–CREB signaling in cancer
Open accessAbstract
Cyclic adenosine monophosphate (cAMP) is the first discovered second messenger, which plays pivotal roles in cell signaling, and regulates many physiological and pathological processes. cAMP can regulate the transcription of various target genes, mainly through protein kinase A (PKA) and its downstream effectors such as cAMP-responsive element binding protein (CREB). In addition, PKA can phosphorylate many kinases such as Raf, GSK3 and FAK. Aberrant cAMP–PKA signaling is involved in various types of human tumors. Especially, cAMP signaling may have both tumor-suppressive and tumor-promoting roles depending on the tumor types and context. cAMP–PKA signaling can regulate cancer cell growth, migration, invasion and metabolism. This review highlights the important roles of cAMP–PKA–CREB signaling in tumorigenesis. The potential strategies to target this pathway for cancer therapy are also discussed.
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1 retracted
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Targeting mTOR for cancer therapy
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Self-citationOverview of PDEs and Their Regulation
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Regulation of the phosphoinositide code by phosphorylation of membrane readers
Kervin, T. A., & Overduin, M. (2021) · Cells · doi:10.3390/cells10051205 · Cited by 13
Seo, J., Jeong, C., Oh, S., Lee, S.-Y., Park, H., Seo, D., Yoo, D., Sim, W.-J., Lim, T.-G., Park, J. H. Y., et al. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5454 · Cited by 6
Metadata
- Authors
- Zhang, H., Kong, Q., Wang, J., Jiang, Y., & Hua, H.
- Venue
- Experimental Hematology & Oncology
- Published
- 2020-11-24
- Volume
- 9
- Issue
- 1
- Pages
- 32-32
- ISSN
- 2162-3619 (ISSN-L)
- OpenAlex
- W3107791012
- Cited by
- 466
- References
- 133
- FWCI
- 12.65
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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