The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Engineering tenofovir loaded chitosan nanoparticles to maximize microbicide mucoadhesion
Open accessAbstract
The objective of this study was to engineer a model anti-HIV microbicide (Tenofovir) loaded chitosan based nanoparticles (NPs). Box-Behnken design allowed to assess the influence of formulation variables on the size of NPs and drug encapsulation efficiency (EE%) that were analyzed by dynamic light scattering and UV spectroscopy, respectively. The effect of the NPs on vaginal epithelial cells and Lactobacillus crispatus viability and their mucoadhesion to porcine vaginal tissue were assessed by cytotoxicity assays and fluorimetry, respectively. In the optimal aqueous conditions, the EE% and NPs size was 5.83% and 207.97nm, respectively. With 50% (v/v) ethanol/water as alternative solvent, these two responses increased to 20% and 602 nm, respectively. Drug release from medium (281 nm) and large size (602 nm)-sized NPs fitted the Higuchi (r2=0.991) and first-order release (r2=0.999) models, respectively. These NPs were not cytotoxic to both the vaginal epithelial cell line and Lactobacillus for 48 hours. When the diameter of the NPs decreased from 900 nm to 188 nm, the mucoadhesion increased from 6% to 12%. However, the combinatorial effect of EE% × mucoadhesion for larger size NPs was the highest. Overall, large-size, microbicide loaded chitosan NPs appeared to be promising nanomedicines for the prevention of HIV transmission.
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Modeling and comparison of dissolution profiles
Costa, P., & Sousa Lobo, J. M. (2001) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(01)00095-1 · Cited by 5,509
Abdool Karim, Q., Abdool Karim, S. S., Frohlich, J. A., Grobler, A. C., Baxter, C., Mansoor, L. E., Kharsany, A. B. M., Sibeko, S., Mlisana, K. P., Omar, Z., et al. (2010) · Science · doi:10.1126/science.1193748 · Cited by 2,435
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Li, Y., Maciel, D., Rodrigues, J., Shi, X., & Tomás, H. (2015) · Chemical Reviews · doi:10.1021/cr500131f · Cited by 478
Biopolymer-based functional composites for medical applications
Park, S.-B., Lih, E., Park, K.-S., Joung, Y. K., & Han, D. K. (2017) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2016.12.003 · Cited by 429
Polymer-based nanocarriers for vaginal drug delivery
das Neves, J., Nunes, R., Machado, A., & Sarmento, B. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.12.004 · Cited by 138
Metadata
- Authors
- Meng, J., Sturgis, T. F., & Youan, B.-B. C.
- Venue
- European Journal of Pharmaceutical Sciences
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 44
- Issue
- 1-2
- Pages
- 57-67
- ISSN
- 0928-0987 (ISSN-L)
- OpenAlex
- W2075432922
- Cited by
- 172
- References
- 2
- FWCI
- 7.36
- Type
- journal article
- Language
- en
- Open access
- green
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- Meng, J., Sturgis, T. F., & Youan, B.-B. C. (2011). Engineering tenofovir loaded chitosan nanoparticles to maximize microbicide mucoadhesion. European Journal of Pharmaceutical Sciences. https://doi.org/10.1016/j.ejps.2011.06.007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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