Detection of hepatic metastasis: manganese-and ferucarbotran-enhanced MR imaging
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Purpose To compare the mangafodipir trisodium (MnDPDP)-enhanced and ferucarbotran-enhanced magnetic resonance imaging (MRI) for the detection of hepatic metastases.Material and methods Twenty patients with known hepatic metastasis underwent MR imaging using mangafodipir trisodium and ferucarbotran in at least 1-day intervals. Thirty-eight metastases were confirmed either histologically or clinically. Two radiologists independently reviewed the MnDPDP-enhanced and ferucarbotran-enhanced sets in a random order. The sensitivity and accuracy of lesion detection and the ability to distinguish a benign lesion from a malignant lesion were compared by the areas (Az) under the receiver operating characteristic (ROC) curve. The lesion-liver contrast-to-noise ratios (CNR) were compared by paired t-test.Results The overall accuracy for detecting metastases was not significantly different between the MnDPDP set (Az=0.912 and 0.913 for reader 1 and 2, respectively) and the SPIO set (Az=0.920 and 0.950). The CNR at the MnDPDP-enhanced images and the SPIO-enhanced images were not significantly different (P=0.146).Conclusion Both MnDPDP- and ferucarbotran-enhanced MRI have a comparable accuracy in detecting hepatic metastasis.
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SPION have been extensively used for diagnostic purposes, for visualizing tumors and metastases in liver, spleen and lymph nodes, for angiography as a blood pool agent, and for visualizing inflammatory lesions like atherosclerotic plaques.
“SPION have been extensively used for diagnostic purposes, for visualizing tumors and metastases in liver, spleen and lymph nodes [137, 138], for angiography as a blood pool agent [139] and for visualizing inflammatory lesions like atherosclerotic plaques [140].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [138]
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Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
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- Authors
- Choi, J.-Y., Kim, M.-J., Kim, J. H., Kim, S. H., Ko, H.-K., Lim, J. S., Oh, Y. T., Chung, J.-J., Yoo, H. S., Lee, J. T., & Kim, K. W.
- Affiliations
- Seoul National University (KR)
- Yonsei University (KR)
- Corresponding author
- Kim, Myeong-Jin
- ORCID
- Venue
- European Journal of Radiology
- Publisher
- Elsevier BV
- Published
- 2006-10
- Volume
- 60
- Issue
- 1
- Pages
- 84-90
- ISSN
- 0720-048X (ISSN-L)
- OpenAlex
- W2031712619
- Cited by
- 29
- References
- 26
- Citations by year
- 2025: 3 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2016: 1 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- European Journal of Radiology (publishedVersion)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Funders
- Yonsei University
- Centre National de la Recherche Scientifique
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- liver metastasis, manganese-enhanced MRI, ferucarbotran, superparamagnetic iron oxide nanoparticles, mangafodipir trisodium, contrast-to-noise ratio, benign versus malignant liver lesions
- MeSH terms
- Adult, Aged, Contrast Media, Dextrans, Edetic Acid, Female, Humans, Image Enhancement, Iron, Liver Neoplasms, Magnetic Resonance Imaging, Male, Middle Aged, Oxides, Pyridoxal Phosphate, Sensitivity and Specificity, Reproducibility of Results, Ferrosoferric Oxide, Magnetite Nanoparticles
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