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Cited by 30Cerebrovascular and Carotid Artery DiseasesAcute Ischemic Stroke ManagementProtease and Inhibitor Mechanisms

Heregulin, Cysteine Rich-61 and Matrix Metalloproteinase 9 Expression in Human Carotid Atherosclerotic Plaques: Relationship with Clinical Data

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Sigala, F., Georgopoulos, S., Papalambros, E., Chasiotis, D., Vourliotakis, G., Niforou, A., Kotsinas, A., Kavantzas, N. +3 more·2006·European Journal of Vascular and Endovascular Surgery
DOI 10.1016/j.ejvs.2006.01.026
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Abstract

Objectives Heregulins (HRGs) are known to induce expression of angiogenic factors such as cysteine rich-61 (CYR61) and collectively to promote neoangiogenesis. Along with extracellular matrix remodelling, mediated by matrix metalloproteinases (MMPs), these factors are important in atherogenesis. The aim of the present study was to investigate HRG, CYR61 and MMP-9 expression and their relationship with clinical and histopathological findings in carotid occlusive disease.Materials and methods Specimens of human carotid atherosclerotic plaque (n=90) were obtained by endarterectomy. Expression of HRG, CYR61 and MMP-9 was assessed by immunohistochemical and Western blot analysis. Associations between protein expression and degree of carotid stenosis, presence of symptoms, presence of an infarct in CT scan and carotid plaque histopathology were investigated.Results An increase in HRG, CYR61 and MMP-9 expression was found, particularly in neovascularized regions of the plaques. High HRG expression was associated with the degree of carotid stenosis (p=0.028) and plaque histopathology (p=0.002). More than half of specimens from plaques with >90% stenosis had intense expression of CYR61 (p=0.047). Increased expression of MMP-9 was associated with degree of stenosis and presence of cerebral infarct on CT scan (p=0.05).Conclusion HRG, CYR61 and MMP-9 are highly expressed in human atherosclerotic carotid plaques. The association with the degree of stenosis and/or plaque histopathology implies an involvement in lesion progression.

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  • CCN1 is overexpressed in vascular smooth muscle cells of atherosclerotic lesions and in the neointima of restenosis after balloon angioplasty, in rodent models and humans.

    “CCN1 is overexpressed in vascular smooth muscle cells of atherosclerotic lesions and in the neointima of restenosis after balloon angioplasty, both in rodent models and in humans [23,56,58,135].”

    From CCN1/CYR61: the very model of a modern matricellular protein (2011) · cites this paper as [135]

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Authors
Sigala, F., Georgopoulos, S., Papalambros, E., Chasiotis, D., Vourliotakis, G., Niforou, A., Kotsinas, A., Kavantzas, N., Patsouris, E., Gorgoulis, V. G., & Bastounis, E.
Affiliations
National and Kapodistrian University of Athens (GR)
Corresponding author
Georgopoulos, S.
ORCID
Venue
European Journal of Vascular and Endovascular Surgery
Publisher
Elsevier BV
Published
2006-09
Volume
32
Issue
3
Pages
238-245
ISSN
1078-5884 (ISSN-L)
DOI
10.1016/j.ejvs.2006.01.026
OpenAlex
W2055039350
Cited by
30
References
27
Citations by year
2026: 1 · 2024: 1 · 2023: 2 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 2
FWCI
2.37
Type
journal article
Language
en
Open access
Licence
Locations
  • European Journal of Vascular and Endovascular Surgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Keywords
neuregulin-1, cysteine-rich protein 61, MMP-9, carotid plaque, carotid artery stenosis, neovascularization, extracellular matrix remodeling, cerebral infarction, plaque histopathology, atherosclerosis progression, angiogenesis
MeSH terms
Carotid Artery Diseases, Female, Humans, Immunohistochemistry, Macrophages, Male, Risk Factors, Blotting, Western, Electrophoresis, Gel, Two-Dimensional, Tunica Intima, Immediate-Early Proteins, Matrix Metalloproteinase 9, Neuregulin-1, Intercellular Signaling Peptides and Proteins, Cysteine-Rich Protein 61

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