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Exposure to metal mixtures and human health impacts in a contaminated area in Nanning, China
Open accessAbstract
Cadmium and lead have been identified as very toxic metals, which are widely present in the environment due to natural and anthropogenic emissions. Many studies have shown that the food chain is the main pathway of cadmium and lead transfer from the environment to humans. It is well documented that many factors will affect their transfer through food chains. Previous investigations on heavy metals were mostly concentrated on one contaminant in isolation. However, in real environments, exposure to mixtures of metals is ubiquitous such that cadmium pollution is invariably being associated with lead and zinc, etc. This study focuses on the contamination and health effects of the metal mixtures. For this purpose, a dietary survey was taken for 3 groups in Nanning in October 2002. Samples of soils, plants (vegetables), urine and blood of humans were measured for Cd, Fe, Cu, Zn, Ca and Pb, in addition, the urinary indicators of renal dysfunction Albumin (ALB), N-acetyl-beta-D-glucosaminidase (NAG), Beta-2-microglobulin (beta2-MG) and Retinol-binding protein (RBP) in urine were also measured. Results showed that soil contamination with metal mixtures had caused significant renal dysfunction of the local residents living in the contaminated area, and the dose-response curve was somewhat altered by the mixed contamination of Cd and Pb as well as the intake of other minerals. The importance of mixtures of metal contamination and human health are also discussed in this paper.
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Potentially toxic elements in soils can transfer to other environmental compartments, such as aquatic ecosystems, through erosion and surface runoff from agricultural land.
“Moreover, PTEs in soils can transfer to other environmental compartments, such as aquatic ecosystems, through erosion and surface runoff from agricultural land (Cui et al., 2005;Luo et al., 2007).”
From Soil amendments for immobilization of potentially toxic elements in contaminated soils: A critical review (2020) · cites this paper as Cui et al., 2005
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Metadata
- Authors
- Cui, Y., Zhu, Y.-G., Zhai, R., Huang, Y., Qiu, Y., & Liang, J.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- Zhu, Yong-Guan
- Venue
- Environment International
- Publisher
- Elsevier BV
- Published
- 2005-08
- Volume
- 31
- Issue
- 6
- Pages
- 784-790
- ISSN
- 0160-4120 (ISSN-L)
- OpenAlex
- W2096436844
- Cited by
- 310
- References
- 26
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 12 · 2023: 13 · 2022: 21 · 2021: 17 · 2020: 16 · 2019: 15 · 2018: 17 · 2017: 16 · 2016: 23 · 2015: 24 · 2014: 21 · 2013: 17 · 2012: 16
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- green
- ir.rcees.ac.cn
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Environment International (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Research Center for Eco-Environmental Sciences OpenIR (Chinese Academy of Sciences) (submittedVersion, cc-by-nc-nd)
- Funders
- Natural Science Foundation of Guangxi Province
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Physical Sciences › Environmental Science › Pollution › Heavy metals in environment
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Keywords
- metal mixtures, cadmium, lead, soil contamination, dietary exposure, renal dysfunction, urinary biomarkers, N-acetyl-beta-D-glucosaminidase, beta2-microglobulin, retinol-binding protein, albumin, dose-response relationship, zinc, Nanning
- MeSH terms
- Acetylglucosaminidase, Albumins, beta 2-Microglobulin, China, Environmental Monitoring, Female, Food Contamination, Humans, Kidney, Male, Retinol-Binding Proteins, Soil Pollutants, Vegetables, Metals, Heavy
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